This article aims to present a numerical study of the behavior of engine main bearings under dynamic load. The coupling performance characteristics of oil film between crankshaft and engine block are analyzed. The film pressure is solved numerically with Reynolds boundary conditions when various bearing characteristics are calculated. Hydrodynamic lubrication is analyzed with finite difference method for solving the Reynolds equation for thermo effect. The other models, such as engine block and crankshaft-connecting rod system, are processed by utilizing the finite element method. Above this system, model applied in this paper is simulated by employing multi-body dynamic method to capture the dynamic characteristics of engine dynamic simulation. Through the methods mentioned above, the performance characteristics of engine main bearings under hydrodynamic loads in a six-cylinder in-line diesel engine were received. And the orbit movement, minimum oil film thickness, and power loss in the bearing were estimated over the wide range of engine operation.