Multicystic Adenomatoid Hamartoma of the Pancreas. A Hitherto Undescribed Pancreatic Tumor Occurring In A 3-Year-Old Boy

Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene

“…Hamartomas are histological malformations that grow in association with quantitative and structural deformities in the process of organ development and are not considered true neoplasms 1 . Although hamartomas are known to develop primarily in the lungs, heart, kidneys and spleen, 2,3 there are scattered case reports of hamartomas in the pancreas 4–17 . The clinical and pathological characteristics of hamartomas reported by Yamaguchi et al .…”

“…1 Although hamartomas are known to develop primarily in the lungs, heart, kidneys and spleen, 2,3 there are scattered case reports of hamartomas in the pancreas. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] The clinical and pathological characteristics of hamartomas reported by Yamaguchi et al include well-demarcated mass formation, differentiated acini, ductal tissue lacking elastic fibres, diffuse endocrine cells and a characteristic lack of islets of Langerhans and peripheral nerve tissue. 18 In addition, the stroma of the lesions is characteristically interspersed with spindle cells.…”

Multiple solid pancreatic hamartomas: A case report and review of the literature

“…Thus, hamartoma seems to be a malformation rather than a true neoplasm. To our knowledge, 17 cases of pancreatic hamartoma have been reported so far in the English literature, and the present case is the 18th [1][2][3][4][5][6][7][8][9][10][11][12] . In 2005, Pauser et al [9] divided pancreatic hamartomas into two subgroups: solid and cystic lesions and solid lesions, and the authors reported two cases of solid hamartoma of the pancreas as a cellular hamartoma resembling a gastrointestinal stromal tumor.…”

“…Non-neoplastic tumor-like lesions in the pancreas are uncommon and include hamartoma [1][2][3][4][5][6][7][8][9][10][11][12] . Mass-forming pancreatitis which is associated with autoimmune pancreatitis, congenital arteriovenous malformation, intra-pancreatic accessory spleen, and others [13,14] .…”