Multicystic pancreatic hamartoma: A distinctive lesion with immunohistochemical and ultrastructural study

Flaherty, Michael J.; Benjamin, Denis R.

doi:10.1016/0046-8177(92)90301-i

Cited by 53 publications

(25 citation statements)

References 20 publications

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“…Non‐neoplastic mass‐forming lesions of the pancreas are extremely rare and include hamartoma, ‘mass‐forming’ pancreatitis, and so on. To our knowledge, 14 cases of hamartoma of the pancreas have been reported in the literature and the present case is the 15th 1–9 Table 1. summarizes the clinicopathological features.…”

Section: Discussionmentioning

confidence: 80%

Solid pancreatic hamartoma

Nagata¹,

Yamaguchi²,

Inoue³

et al. 2007

Pathology International

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A case of solid pancreatic hamartoma in a 58-year-old Japanese woman is presented. She had no symptoms, and a pancreatic mass was incidentally found on screening ultrasonography 4 months before admission. The patient was not alcoholic and had no history of pancreatitis. Physical examination and laboratory data were unremarkable. Preoperative imaging demonstrated a nodule in the body of the pancreas, measuring 2.0 cm in maximum diameter, which showed marked delayed enhancement during dynamic CT. The patient underwent a distal pancreatectomy under the preoperative diagnosis of pancreatic endocrine tumor and had an uneventful postoperative course. A well-demarcated solid nodule, 1.9 cm in diameter, was evident in the body of the pancreas. Microscopically, the lesion was composed of non-neoplastic, disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells, lacking discrete islets. The stromal spindle cells were immunoreactive for CD34 and CD117. The histological diagnosis was solid hamartoma of the pancreas. There was no recurrence 5 months after surgery. Herein is reported a case of solid hamartoma of the pancreas and review of the literature. A search through the literature found only two cases of solid hamartoma of the pancreas, among the 14 cases previously reported as pancreatic hamartoma.

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Section: Discussionmentioning

confidence: 80%

Solid pancreatic hamartoma

Nagata¹,

Yamaguchi²,

Inoue³

et al. 2007

Pathology International

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“…Thus, hamartoma seems to be a malformation rather than a true neoplasm. To our knowledge, 17 cases of pancreatic hamartoma have been reported so far in the English literature, and the present case is the 18th [1][2][3][4][5][6][7][8][9][10][11][12] . In 2005, Pauser et al [9] divided pancreatic hamartomas into two subgroups: solid and cystic lesions and solid lesions, and the authors reported two cases of solid hamartoma of the pancreas as a cellular hamartoma resembling a gastrointestinal stromal tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Non-neoplastic tumor-like lesions in the pancreas are uncommon and include hamartoma [1][2][3][4][5][6][7][8][9][10][11][12] . Mass-forming pancreatitis which is associated with autoimmune pancreatitis, congenital arteriovenous malformation, intra-pancreatic accessory spleen, and others [13,14] .…”

Section: Introductionmentioning

confidence: 99%

Multiple solid pancreatic hamartomas: A case report and review of the literature

Kawakami

Shimizu²,

Yamaguchi³

et al. 2012

WJGO

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Non-neoplastic tumor-like lesions in the pancreas are uncommon. Here, we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman. Her computed tomography revealed a pancreatic mass, measuring 1.8 cm in maximum diameter. However, no symptoms were found. She was not an alcoholic and had no history of pancreatitis. The patient underwent a pancreatoduodenectomy, and three well-demarcated solid nodules measuring 1.7 cm, 0.4 cm, and 0.3 cm in diameter were found in the pancreatic head. Microscopically, the lesions were composed of non-neoplastic, disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets. The stromal spindle cells were immunoreactive for C�34 and C�117. The histological diagnosis was multiple solid hamartomas of the pancreas. There has been no recurrence 30 mo after surgery. So far, 18 cases of pancreatic hamartoma have been reported in the English literature, including our case. Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma. Although the number of cases was limited, solid pancreatic hamartomas seem to be benign tumor-like lesions, which are found incidentally in healthy middle-aged adults, but occasionally involve the whole pancreas, resulting in a poor prognosis. Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality, and multiple small lesions other than the main tumors were detected in a small number of cases. From these findings, one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas.

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“…The child underwent a pancreatoduodenectomy, but died 3 months later. Flaherty and Benjamin [6] reported a 20-month-old female infant with abdominal pain, distension and a well-circumscribed 9-cm multicystic mass in the lower aspect of the head of the pancreas. Histology showed a disordered arrangement of benign pancreatic exocrine, endocrine and ductal cells admixed with fi brous tissue and fat.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic hamartoma

et al. 2004

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Pancreatic hamartoma is a rare benign lesion and may be mistaken for a malignancy, as demonstrated by two cases. The first case was a 29-year-old man who presented with a 7-month history of intermittent upper abdominal pain, nausea and vomiting and a 15-kg weight loss. CT and MRI revealed a mass in the head of the pancreas. The second case was a 62-year-old man who presented with a 2-year history of intermittent abdominal pain, vomiting and a 25-kg weight loss. Although positron emission tomography was normal, CT revealed thickening of the duodenal wall and endoluminal ultrasonography revealed a tumour in the head of the pancreas. Both patients recovered from uneventful Kausch-Whipple pancreatoduodenectomy (in the first patient, it was pylorus-preserving), and in each case the histological diagnosis was hamartoma. Pancreatic hamartoma can present with vague, non-specific symptoms which, despite modern diagnostic tools, can be difficult to diagnose. Surgical resection with histopathological examination is required to confirm the diagnosis.

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Multicystic pancreatic hamartoma: A distinctive lesion with immunohistochemical and ultrastructural study

Cited by 53 publications

References 20 publications

Solid pancreatic hamartoma

Solid pancreatic hamartoma

Multiple solid pancreatic hamartomas: A case report and review of the literature

Pancreatic hamartoma

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