Case Presentation and EvolutionA 26-year-old white male with a prior history of a benign cardiac arrhythmia and seasonal allergies presented with gastrointestinal bleeding and anemia. Two months prior to admission, he was seen in an urgent care clinic with intermittent, crampy left lower quadrant abdominal pain, worse 15-60 min after eating, and associated with alternating constipation and diarrhea. During that visit, a comprehensive metabolic panel, complete blood cell count and right upper quadrant ultrasound were normal. The patient was given the diagnosis of ''vigorous gastrocolic reflex'' and was successfully treated with MiralaxÒ.The patient remained in excellent health until 1 day prior to admission when he began to experience diffuse, infraumbilical, intense pain estimated to be six out of ten in severity, and an urge to defecate. While on the commode, he had an episode of transient pre-syncope. Two large, liquid maroon-colored stools and continuous bowel urgency prompted him to come to the emergency department.He denied any prior history of gastrointestinal bleeding, use of non-steroidal anti-inflammatory drugs, aspirin, alcohol or recreational drugs. He reported nausea but not vomiting and had no change in appetite or weight loss. His family history was negative for gastrointestinal malignancy. He was employed as a lawyer and had smoked one pack of cigarettes per day for 10 years.In the emergency department, his temperature was 36.2°C, pulse 67, blood pressure 97/60 mmHg, respiratory rate 20, and oxygen saturation 99% on room air. He was thin and well appearing, anicteric and slightly pale. There were no stigmata of chronic liver disease. Lungs were clear to auscultation bilaterally. Heart exhibited a regular rate and rhythm, without murmurs, rubs or gallops. His abdomen was soft, nontender and not distended; there was no organomegaly or palpable masses. Rectal examination revealed normal anal tone, no masses and liquid maroon stool.Two large bore intravenous catheters were placed, a 1-L saline bolus was given, and a nasogastric tube was placed without return of blood or bile. Laboratory tests showed white blood cell count 7,900/mm 3 , hematocrit 36.8%, platelet count 123,000/mm 3 , sodium 137 mmol/L, cloride 103 mmol/L, carbon dioxide 29 mmol/L, blood urea nitrogen 22 mg/dL, and creatinine 1.0 mg/dL. Liver function tests were normal. He was admitted to the general medical service, kept fasting with an active blood bank sample, and stool studies were sent to rule out infectious colitis. A pantoprazole drip was empirically initiated. A colonoscopy was performed the following day after bowel preparation, and blood was seen throughout the colon and terminal ileum.Twenty-four hours later, in the setting of continuous rectal bleeding, his hematocrit dropped to 24.2%. After a total of six units of packed red blood cells throughout the ensuing day, his hematocrit was 27%. In order to localize the source of bleeding, a computed tomography (CT) scan was performed using an angiography protocol. The CT revealed ac...