Multidimensional endotyping using nasal proteomics predicts molecular phenotypes in the asthmatic airways

Agache, Ioana; Shamji, Mohamed H.; Kermani, Nazanin Zounemat; Vecchi, Giulia; Favaro, Alberto; Layhadi, Janice A.; Heider, Anja; Akbas, Didem Sanver; Filipaviciute, Paulina; Wu, Lily Y.D.; Cojanu, Cătălina; Laculiceanu, Alexandru; Akdiş, Cezmi A.; Adcock, Ian M.

doi:10.1016/j.jaci.2022.06.028

Cited by 12 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cluster patients had significant air trapping and higher oxidative stress levels, which were significantly associated with neutrophilic inflammation and infection activation. 45 A cluster analysis found that this special cluster had lower lung function and greater urgent care visit history in asthma patients. 46 Several mechanisms may explain the effect of this cluster.…”

Section: Discussionmentioning

confidence: 95%

“…applied unsupervised clustering of biomarkers to describe asthma endotypes and found a special cluster type. Cluster patients had significant air trapping and higher oxidative stress levels, which were significantly associated with neutrophilic inflammation and infection activation 45. A cluster analysis found that this special cluster had lower lung function and greater urgent care visit history in asthma patients 46…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study

Yang

Wen

et al. 2023

BMJ Open Resp Res

View full text Add to dashboard Cite

BackgroundThe inter-relationships among neutrophilic airway inflammation, air trapping and future exacerbation in chronic obstructive pulmonary disease (COPD) remain unclear.ObjectiveTo evaluate the associations between sputum neutrophil proportions and future exacerbation in COPD and to determine whether these associations are modified by significant air trapping.MethodsParticipants with completed data were included and followed up to the first year in the Early Chronic Obstructive Pulmonary Disease study (n=582). Sputum neutrophil proportions and high-resolution CT-related markers were measured at baseline. Sputum neutrophil proportions were dichotomised based on their median (86.2%) to low and high levels. In addition, subjects were divided into the air trapping or non-air trapping group. Outcomes of interest included COPD exacerbation (separately any, severe and frequent exacerbation, occurring in the first year of follow-up). Multivariable logistic regressions were performed to examine the risk of severe exacerbation and frequent exacerbation with either neutrophilic airway inflammation groups or air trapping groups.ResultsThere was no significant difference between high and low levels of sputum neutrophil proportions in the exacerbation in the preceding year. After the first year of follow-up, subjects with high sputum neutrophil proportions had increased risks of severe exacerbation (OR=1.68, 95% CI: 1.09 to 2.62, p=0.020). Subjects with high sputum neutrophil proportions and significant air trapping had increased odds of having frequent exacerbation (OR=3.29, 95% CI: 1.30 to 9.37, p=0.017) and having severe exacerbation (OR=2.72, 95% CI: 1.42 to 5.43, p=0.003) when compared with those who had low sputum neutrophil proportions and non-air trapping.ConclusionsWe found that subjects with high sputum neutrophil proportions and significant air trapping are prone to future exacerbation of COPD. It may be a helpful predictor of future exacerbation.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study

Yang

Wen

et al. 2023

BMJ Open Resp Res

View full text Add to dashboard Cite

show abstract

“…During the last two decades, high throughput technologies and analysis of multi‐omics datasets have significantly contributed to increasing the resolution in identifying the triggers and pathomechanisms of diseases 15 . In addition, the introduction of precision medicine, the concepts of disease endotypes, genotypes, theratypes and regiotypes have helped to stratify patients based on disease mechanisms to optimize the management of allergic diseases 16–18 …”

Section: Introductionmentioning

confidence: 99%

“…During the last two decades, high throughput technologies and analysis of multi-omics datasets have significantly contributed to increasing the resolution in identifying the triggers and pathomechanisms of diseases. 15 In addition, the introduction of precision medicine, the concepts of disease endotypes, genotypes, theratypes and regiotypes have helped to stratify patients based on disease mechanisms to optimize the management of allergic diseases. [16][17][18] Artificial intelligence (AI) and machine learning have emerged as powerful tools for analysing complex datasets delivered by the new precision diagnostic tools, identifying patterns that may not be readily apparent to human researchers.…”

Section: Introductionmentioning

confidence: 99%

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

Jutel,

Agache,

Zemelka‐Wiacek

et al. 2023

Allergy

Self Cite

View full text Add to dashboard Cite

The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies and patient access to extensive health care, has resulted in vast amounts of unbiased data enabling in‐depth disease characterization. New disease endotypes have been identified for various allergic diseases and triggered the gradual transition from a disease description focused on symptoms to identifying biomarkers and intricate pathogenetic and metabolic pathways. Consequently, the current disease taxonomy has to be revised for better categorization. This European Academy of Allergy and Clinical Immunology Position Paper responds to this challenge and provides a modern nomenclature for allergic diseases, which respects the earlier classifications back to the early 20th century. Hypersensitivity reactions originally described by Gell and Coombs have been extended into nine different types comprising antibody‐ (I‐III), cell‐mediated (IVa‐c), tissue‐driven mechanisms (V‐VI) and direct response to chemicals (VII). Types I‐III are linked to classical and newly described clinical conditions. Type IVa‐c are specified and detailed according to the current understanding of T1, T2 and T3 responses. Types V‐VI involve epithelial barrier defects and metabolic‐induced immune dysregulation, while direct cellular and inflammatory responses to chemicals are covered in type VII. It is notable that several combinations of mixed types may appear in the clinical setting. The clinical relevance of the current approach for allergy practice will be conferred in another article that will follow this year, aiming at showing the relevance in clinical practice where various endotypes can overlap and evolve over the lifetime.

show abstract

“…The second editor's choice article in this issue explores biomarkers 4,5 in eosinophilic and neutrophilic asthma. Depending on the immunological profile in the blood or sputum of an individual with asthma , they can be classified as having eosinophilic asthma , neutrophilic asthma , mixed granulocytic asthma ( MGA ) or paucigranulocytic asthma ( PGA , few granulocytes ) 6 .…”

mentioning

confidence: 99%

Biological therapy practice, biomarkers of severe asthma and novel approaches for attaining immunomodulation in upper airway disease

Shamji

Boyle

2023

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

Multidimensional endotyping using nasal proteomics predicts molecular phenotypes in the asthmatic airways

Cited by 12 publications

References 31 publications

Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study

Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

Biological therapy practice, biomarkers of severe asthma and novel approaches for attaining immunomodulation in upper airway disease

Contact Info

Product

Resources

About