A domain wall of relative phase in a flattened harmonically-trapped Bose-Einstein condensed mixture of two atomic hyperfine states, subject to a stationary Rabi coupling of intensity Ω, is predicted to decay through two different mechanisms. For small values of Ω the instability has an energetic nature and is associated with the formation of a vortex-antivortex pair of the same atomic hyperfine states, whose motion inside the trap causes the emergence of magnetization, the bending of the domain wall and its consequent fragmentation. For large values of Ω the domain wall instead undergoes a dynamic snake instability, caused by the negative value of its effective mass and results in the fast fragmentation of the wall into smaller domain walls confining vortex pairs of different atomic species. Numerical predictions are given by solving the time-dependent Gross-Pitaevskii equation in experimentally available configurations of mixtures of sodium atomic gases.The study of topological defects in ordered phases encompasses different fields of physics from quantum fluids and superconductors to cosmology. Of particular interest is the case of composite defects due to the presence of multiple symmetry breaking [1]. In this respect ultracold gases mixtures are emerging as one of the most suitable platforms for studying the dynamical behaviour of topological defects and in particular their formation and decay. The easiest system showing interesting composite defects is most probably a binary Bose-Bose mixture with an interconversion term, realized via external coherent Rabi coupling, between two hyperfine components [2][3][4][5]. The intriguing features of such a gas are related to the controlled -via the tunability of the Rabi coupling -breaking of the conservation of the relative atom number. Only the total atom number is conserved, due to the U (1) symmetry related global phase (see, e.g., [6] and reference therein).An interesting solitonic solution is represented by the sine-Gordon domain wall of the relative phase, explored by Son and Stephanov [7] for Bose-Einstein condensed gases and by Tanaka [8] for two-band superconductors. The relative phase domain wall (hereafter simply called domain wall) is characterized by an asymptotic 2π jump of the relative phase between the two condensates, whose space gradient is localized in a narrow region fixed by the strength of the Rabi coupling, which makes it energetically costly. Such a solitonic configuration is particularly relevant because it provides non trivial constraints on the topology of quantized vortices. Indeed, in the presence of coherent coupling between the two condensates, a quantized vortex in one of the two components of the mixture, also known as half-quantized vortex, has always a domain wall attached to it. As a consequence isolated halfquantized vortices cannot exist, but are rather paired in order to screen the relative phase change. This situa-tion is reminiscent of the problem of quarks in particle physics, which cannot exist as individual particles, but ...