Four-dimensional signal constellations based on the checkerboard lattice D 4 offer a packing gain over conventional QAM constellations per polarization. Due to the increased number of nearest neighbors such power-efficient 4D formats cannot be Gray-labeled and bit-interleaved coded modulation results in a considerable performance loss. Instead, a suited coded-modulation scheme must be tailored to the properties of the underlying signal lattice. We apply a low-complexity two-stage coded-modulation scheme for constellations based on the set of Hurwitz integers, an isomorphic representation of the D 4 lattice. The proposed signaling scheme is evaluated in numerical simulations and fiber-optical system experiments. The performance is compared to a reference implementation using square QAM formats as proposed in the current 400ZR standardization activities. We demonstrate a 0.8 dB gain in required OSNR of the 512-ary Hurwitz constellation over dual-polarization 16-QAM (with 256 signal points in 4D) at the same symbol and bit rate. Additional numerical and experimental results show the potential for applications in the long-haul as well as the short-reach regime. Index Terms-Two-stage coded modulation, Hurwitz constellations, 4D modulation techniques, D 4 lattice, packing gain, bit-interleaved coded modulation, OIF 400ZR. I. INTRODUCTION T HE application of four-dimensional (4D) and higherdimensional modulation has been intensively investigated over the last decade ever since it was first introduced to the fiber-optical communications community in [1], [2]. The four orthogonal components of the electromagnetic field constitute the natural basis for 4D signal sets. It is well known that the density of signal points per unit volume can be doubled when Manuscript