Multidirectional sorting modes in deterministic lateral displacement devices

Long, Brian; Heller, Martin; Beech, Jason P.; Linke, Heiner; Bruus, Henrik; Tegenfeldt, Jonas O.

doi:10.1103/physreve.78.046304

Cited by 66 publications

(56 citation statements)

References 11 publications

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“…Recent progress and potential future directions in the area of inertial microfluidics are discussed in a recent review article by Di Carlo. 73 Even though prototype systems utilizing inertial microfluidics show more rapid and high-throughput outcomes compared to other promising techniques, such as microfiltration, 26,74,75 deterministic lateral displacement, 30,[76][77][78] and hydrophoresis, 79,80 they lack the ability to increase the concentration of the target cells to a significant value. This issue is recently resolved by combining microscale laminar vortices with inertial focusing.…”

Section: A Inertial Effectsmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

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Focusing and sorting cells and particles utilizing microfluidic phenomena have been flourishing areas of development in recent years. These processes are largely beneficial in biomedical applications and fundamental studies of cell biology as they provide cost-effective and point-of-care miniaturized diagnostic devices and rare cell enrichment techniques. Due to inherent problems of isolation methods based on the biomarkers and antigens, separation approaches exploiting physical characteristics of cells of interest, such as size, deformability, and electric and magnetic properties, have gained currency in many medical assays. Here, we present an overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels. Our emphasis is on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows. We also highlight the advantages and drawbacks of each method in terms of throughput, separation efficiency, and cell viability. Finally, we discuss the future research areas for extending the scope of hydrodynamic mechanisms and exploring new physical directions for microfluidic applications.

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Section: A Inertial Effectsmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

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“…[1][2][3][4][5][6][7][8][9][10] It has, in fact, been successfully used in a number of applications, especially for the separation of biological samples. [11][12][13][14][15][16][17][18] Although in most cases DLD is described (and investigated) as a size-based separation technique, it could also separate particles based on shape and flexibility 19,20 and may contribute to the growing field of chiral separation.…”

Section: Introductionmentioning

confidence: 99%

Inertia and scaling in deterministic lateral displacement

2013

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The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based on the transport of species through an array of obstacles. In the case of force-driven DLD (f-DLD), size-based separation can be modelled effectively using a simple particle-obstacle collision model. We use a macroscopic model to study f-DLD and demonstrate, via a simple scaling, that the method is indeed predominantly a sizebased phenomenon at low Reynolds numbers. More importantly, we demonstrate that inertia effects provide the additional capability to separate same size particles but of different densities and could enhance separation at high throughput conditions. We also show that a direct conversion of macroscopic results to microfluidic settings is possible with a simple scaling based on the size of the obstacles that results in a universal curve. V C 2013 AIP Publishing LLC.

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“…DLD has been successfully implemented for the fractionation of diverse samples. [9,10,18,22,38,39] In previous work, we investigated the mechanisms leading to separation in DLD and demonstrated an alternative operation mode, in which suspended species are driven through a two-dimensional (2D) array of posts by a constant force, specifically gravity (g-DLD). [2,6,12,15,21,30?…”

Section: Introductionmentioning

confidence: 99%

Deterministic fractionation of binary suspensions moving past a line of microposts

Devendra¹,

Drazer²

2014

Microfluid Nanofluid

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We investigate the motion of suspended particles past a single line of equally spaced cylindrical posts that is slanted with respect to the driving force. We show that such a one-dimensional array of posts can fractionate particles according to their size, with small particles permeating through the line of posts but larger particles being deflected by the steric barrier created by the posts, even though the gaps between posts are larger than the particles. We perform characterization experiments driving monodisperse suspensions of particles of different size past the line of posts over the entire range of forcing orientations and present both the permeation probability through the individual gaps between the posts as well as the fraction of permeating particles through the one-dimensional array. In both cases, we observe a sharp transition from deflection to permeation mode that is a function of particle size, thus enabling separation. We then drive binary mixtures at selected orientations of the line of posts and demonstrate high purity and efficiency of separation.

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Multidirectional sorting modes in deterministic lateral displacement devices

Cited by 66 publications

References 11 publications

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Inertia and scaling in deterministic lateral displacement

Deterministic fractionation of binary suspensions moving past a line of microposts

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