Multidisciplinary approach to giant paratesticular liposarcoma

Sopeña-Sutil, R.; Silan, Francesco; Butrón-Vila, M. Teresa; Guerrero-Ramos, Félix; Lagaron-Comba, Emilio; Passas-Martínez, J.B.

doi:10.5489/cuaj.3346

Cited by 9 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To the best of our knowledge, about 200 cases of PLS have been reported to date (1). Giant PLS is more rare with only a few cases having been reported (2)(3)(4)(5)(6). Due to the rarity of the disease, there is no standardized guideline as regards its incidence, diagnosis, recurrence and treatment (7,8).…”

Section: Introductionmentioning

confidence: 99%

Giant paratesticular liposarcoma: A case report and review of the literature

Zhou

Zhao

et al. 2018

mol clin onc

View full text Add to dashboard Cite

Abstract. Paratesticular liposarcoma is an infrequent tumor characterized by a growing, painless, inguinal or scrotal mass. Only about 200 cases have been reported as of yet in literature, however there are a few cases regarding giant paratesticular liposarcoma measuring over 10 cm. The disease may be commonly misdiagnosed prior to operation. Improper treatment tends to lead to local recurrence and distant metastasis. The current report presents a case of a 51-year-old patient with a large, painless right scrotum. Magnetic resonance imaging revealed a 7.8x5.8x10.4 cm nonhomogeneous space-occupying lesion of the right testis, which was firstly diagnosed as a spermatocytoma. Following this, a radical orchiectomy of the right testis was performed, however, it appeared to be a dedifferentiated liposarcoma, following histopathological examination and immunohistochemistry. Due to the large size of the tumor, it is significant to report the characteristics, diagnosis and treatment of the similar cases. The current study additionally presents a supplementary review of previously published cases in literature and focuses on discussion regarding the clinical characteristics, diagnosis, histopathology and immunohistochemical features and treatment of this disease. IntroductionLiposarcoma, a malignant tumor derives from mesodermal tissues, represents ~20% of all sarcomas. Paratesticular liposarcoma (PLS) is a rare condition. To the best of our knowledge, about 200 cases of PLS have been reported to date (1). Giant PLS is more rare with only a few cases having been reported (2-6). Due to the rarity of the disease, there is no standardized guideline as regards its incidence, diagnosis, recurrence and treatment (7,8). In this study, we present a case of a giant dedifferentiated PLS of the right testis with magnetic resonance imaging (MRI) measuring 7.8x5.8x10.4 cm and focus on the discussion about the clinical characteristics, diagnosis and treatment of this disease. Due to the giant size of this PLS, we report this case for the characteristics, diagnosis and treatment of the similar cases. The study was supported by the Ethics Committee of Peking University Shenzhen Hospital (Shenzhen, China) and written informed consent was obtained from the patient for the publication of the case details. Case reportIn July 2017, a 51-year-old man, with a complaint of swelling of the right scrotum for 2 months, was admitted to the Department of Urology of our hospital. He presented with a painless and slow-growing fixed mass in the right scrotum without conspicuous promoting or alleviating factors. There are no other signs or symptoms. A rigid mass in the right scrotum, about 8 cm in maximum diameter, was the only positive finding of physical examinations. There are no specific abnormalities in the laboratory and imaging examinations (hemogram, urinalysis, stool routine, ESR, β-human chorionic gonadotropin, a-fetoprotein, mycobacterium tuberculosis antibody Ig-G, liver and kidney function tests and chest X-ray). However, magnetic resonance ...

show abstract

Section: Introductionmentioning

confidence: 99%

Giant paratesticular liposarcoma: A case report and review of the literature

Zhou

Zhao

et al. 2018

mol clin onc

View full text Add to dashboard Cite

show abstract

“…Reasons to consider adjuvant radiotherapy would be for high-grade tumors or tumors with a high risk of local recurrence, since some of these tumors are radiosensitive. Chemotherapy could be used as another strategy in cases of dedifferentiated or metastatic disease [ 4–6 , 8 , 9 ] as in our case.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated liposarcoma of the scrotum. Case report and literature review

Salas-Parra¹,

Tavares

Gupta³

et al. 2020

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Malignant paratesticular and spermatic cord tumors are rare and often misdiagnosed preoperatively due to clinical presentations similar to other benign scrotal mass etiologies. Only a few cases regarding giant, paratesticular liposarcomas (>10 cm) have been reported. We report a unique case of an aggressive giant dedifferentiated liposarcoma of the scrotum with osteosarcoma features in a 70-year-old patient who initially presented with indolent scrotal swelling. A CT scan showed a large, complex, solid and cystic mass (12.0 x 15.5 x 19.0 cm) in the right scrotum. With a concern of a complex hydrocele, the patient was taken to the operating room for a scrotal approach to excise the hydrocele, but the spermatic cord was not traced to any discernible testicle as the entire mass was indurated and multilocular, and was excised. Pathology revealed a dedifferentiated liposarcoma, with MDM2 amplification. The patient’s course was complicated due to metastatic disease.

show abstract

“…The most common site of origin is the spermatic cord accounting for 90% of cases [6]. There are few cases of the giant PLS reported to date in the English literature [4, 5]. Liposarcomas are the most common soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

“…In this paper, we report a case of a giant well-differentiated paratesticular liposarcoma of the left testis with a left pelvic mass measuring 15x7x17 cm. We present this case because giant PLS is more rare with only a few cases having been reported [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Paratesticular liposarcoma: a case report

Mouden¹,

Wakrim²,

Semmar³

2019

Pan Afr Med J

View full text Add to dashboard Cite

Paratesticular liposarcomas (PLS) is a very uncommon pathology type of paratesticular sarcomas, with less 200 similar cases reported to date in the English literature. There are a few cases regarding giant paratesticular liposarcoma measuring over 10 cm. We present an unusual case with a giant well differentiated PLS of the left testis extended to the pelvic cavity. We report the case of a 55-year-old man who presented with large left groin mass. The patient underwent left orchiectomy following a cure of a scrotal hernia. Histological and immunohistochemical findings were suggestive of a well-differentiated liposarcoma of spermatic cord. The surgical margins were positive. Metastatic work-up, which included CT of the thorax, abdomen and pelvis, did not reveal any distant metastasis in thorax but there is a left pathological external iliac lymph nodes and a left lateroplevic lipomatous mass extended to the iliac fossa and left parietocolic gutter up to the umbilicus measuring 15x7x17 cm. Our patient refused treatment. A review of the literature revealed that there are fewer cases of giant well differentiated paratesticular liposarcoma extended to the pelvic cavity were reported. This study focuses on the clinical characteristics and treatment of this rare type of tumours.

show abstract

Multidisciplinary approach to giant paratesticular liposarcoma

Cited by 9 publications

References 11 publications

Giant paratesticular liposarcoma: A case report and review of the literature

Giant paratesticular liposarcoma: A case report and review of the literature

Dedifferentiated liposarcoma of the scrotum. Case report and literature review

Paratesticular liposarcoma: a case report

Contact Info

Product

Resources

About