In order to make the pump as turbine (PAT) run efficiently and safely, a multidisciplinary optimization design method for PAT blade, which gives consideration to both the hydraulic and intensity performances, is proposed based on multidisciplinary feasibility (MDF) optimization strategy. This method includes blade parametric design, Latin Hypercube Sampling (LHS) experimental design, CFD technology, FEA technology, GA-BP neural network and NSGA-II algorithm. Specifically, a parameterized PAT blade with cubic non-uniform B-spline curve is adopted, and the control point of blade geometry is taken as the design variable. The LHS experimental design method obtains the sample points of training GA-BP neural network in the design space of variables. The hydraulic performance of each sample point (including the hydraulic pressure load on the blade surface) and the strength performance analysis of blades are completed by CFD and FEA technology respectively. In order to save calculation time of the whole optimization design, the multi-disciplinary performance analysis of each sample in the optimization process is completed by single-coupling method. Then, GA-BP neural network is trained. Finally, the multi-disciplinary optimization design problem of PAT blade is solved by the optimization technology combining GA-BP neural network and NSGA-II algorithm. Based on this optimization method, the PAT blade is optimized and improved. The efficiency of the optimized PAT is improved by 1.71% and the maximum static stress on the blade is reduced by 7.98%, which shows that this method is feasible.