Multidisciplinary Management of Hepatocellular Carcinoma

Postoperative adjuvant arterial chemoembolization improves the survival of hepatitis B virus-related hepatocellular carcinoma: a retrospective control study

“…HCC is a complex condition because of multiple variables, such as liver function, performance status of the patient, and tumor conditions, that can affect the course of HCC' and the response to treatment [1,2]. Hepatitis B virus (HBV) infection is also an important risk factor for the development of HCC, and over 85 % of patients with HCC present with HBV infection in China [3].…”

Regional Yttrium-90 Microsphere Treatment of Surgically Unresectable and Chemotherapy-Refractory Metastatic Liver Carcinoma

“…For these patients, a wide variety of local and regional therapies have been developed from the experience of treating hepatocellular carcinoma for the purpose of providing local control of liver tumors while sparing essential vascular structures, liver parenchyma, and adjacent organs. 1,2 Yttrium-90 glass and resin microspheres have been shown to be chemically durable for in vivo delivery of ␤-radiation . 3 Recently, hepatic intra-arterial infusion of yttrium-90 glass or resin microspheres has been introduced for palliating unresectable hepatocellular carcinoma.…”

Current Treatment for Hepatocellular Carcinoma

“…Unfortunately, more than 80% of patients are symptomatic by the time of diagnosis (Hammett & Gollan, 2001). Patients with symptomatic HCC complain of nonspecific symptoms such as right upper abdominal pain, weight loss, weakness, fullness, anorexia, and possible jaundice (Gogel et al, 2000;Rilling & Drooz, 2002). The most common finding on physical examination is an enlarged, irregular, and nodular liver.…”

“…Unfortunately, less than a third of patients with cirrhosis and HCC are surgical candidates because of the severity of cirrhosis and/or the diffuse distribution of the tumor (Cha et al;Yu & Keeffe, 2003). Additionally, most patients experience a recurrence in the remnant liver, even after curative resection (Rilling & Drooz, 2002).…”