Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epilepsy

Association of MDR1 , CYP2D6 , and CYP2C19 gene polymorphisms with prophylactic migraine treatment response

“…The second step of our study involved assessing the efficiency of prophylactic treatment in migraine patients for each drug separately and comparing the responses to the treatment with the detected polymorphisms. In the literature, the association between antiepileptic drugs and genetic polymorphisms has been evaluated in many studies [25][26][27]. In our study, we found a statistical significance between the response to TPM and presence of the MDR1 C3435T polymorphism (p = 0.020).…”

“…Studies investigating the association between MDR1 C3435T polymorphism and drug resistance in Turkish epilepsy patients suggested that there was no association between drug-resistant epilepsy and MDR1 C3435T polymorphism. However, in two studies that were conducted on pediatric patients [16,25], a different active anticonvulsant was used [26]. A meta-analysis (2014) showed that MDR1 C3435T polymorphism was a risk factor for resistance to antiepileptic drugs, especially in a Caucasian population including Turkish patients [27].…”

“…The best defined MDR1 polymorphism that contributes to increased protein activity is MDR1 C3435T. Studies assessing this polymorphism in terms of its response to antiepileptic drugs have differed in their findings, which still remain controversial [11,12]. While there are studies focusing on epileptic patients, the association between the responses of migraine patients to antiepileptic drugs as a prophylactic treatment in migraine and the MDR1 polymorphism has yet to be assessed.…”

CYP3A5*3 and C3435T MDR1 Polymorphisms in Prognostication of Drug-Resistant Epilepsy in Children and Adolescents

“…The results of that study are in compliance with the study of Siddiqui [48] and confirm the assumption of connection between drug resistance and P-gp with a specific genotype. However, the latest study by Saygi et al on groups of children with drug-resistant epilepsy and epilepsy reacting well to AEDs failed to confirm the connection between C3435T MDR1 polymorphism and the occurrence of resistance to drugs in children with epilepsy [56]. …”

ABCB1 gene polymorphisms is not associated with drug-resistant epilepsy in Romanian children

“…On the other hand, the association among drug therapy response and C3435T genotype observed in these studies was not confirmed by other studies that included patients with similar ethnic characteristics. [8][9][10][11].…”