Multidrug-Resistance Among Uropathogenic Escherichia coli Strains

Tajbakhsh, Ramin; Firoozeh, Farzaneh

doi:10.34172/ijep.2020.01

Cited by 3 publications

(3 citation statements)

References 7 publications

(10 reference statements)

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“…A total of 1515 samples were cultured between the years 2013-2015 at the UCC hospital Laboratory with a slightly predominant female prevalence of 51.33%, 69.20% and 63.36% for 2013, 2014 and 2015 respectively. The median (95% CI) for the age 21-40 years for 2013 was 26 (25)(26)(27)(28), 2014 was 26 (25)(26)(27) and 2015 was 25 (25)(26). High vaginal swab (40.64%, 39.45% & 36.64%) and urine (37.97%, 58.85% & 55.22%) were the most frequent sample collected from 2013-2015 (Table 1).…”

Section: Demographic Characteristics Of the Patientsmentioning

confidence: 99%

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Antibiotic-resistant pathogenic bacterial isolates from patients attending the outpatient department of university of Cape Coast hospital, Ghana: A retrospective study between 2013–2015

Asare

Amoah

Coomson

et al. 2022

PLOS Glob Public Health

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Uropathogenic Escherichia coli (E. coli) is an important urinary tract infection (UTI) that has been associated with both complicated and uncomplicated disease conditions. The global emergence of multiple drug-resistant (MDR) and extended-spectrum β-lactamase (ESBL) is of public health concern as the resistance limits the current treatment options. The objective of this study was to analyze the antibiotic-resistant patterns among the uropathogenic E. coli isolates at the University of Cape Coast (UCC) hospital between 2013 and 2015 as baseline data to understand the current antibiotic resistance situation within UCC and its environs. A retrospective cross-sectional study of bacteria isolates at UCC hospital from January 2013 to December 2015 were analyzed. A standard biochemical and antibiotic susceptibility tests were performed using Kirby-Bauer NCCLs modified disc diffusion technique. The network of interaction between pathogenic isolates and antibiotic resistance was performed using Cytoscape software. Statistical significance was tested using ANOVA and one-sample Wilcoxon test. The overall E. coli prevalence was 15.76% (32/203); females had the highest infection of 17.33% (26/150) compared to male subjects who had 11.32% (6/53) out of all the pathogenic infections. The E. coli prevalence among the age categories were 2/21 (9.52%), 27/154 (17.53%) and 4/21 (19.05%) among ≤20 years, 21–40 years and 41–60 years respectively. The isolated resistant pathogens exhibited different antibiotic resistance patterns. An interaction network of nodes connecting to other nodes indicating positive correlations between the pathogens and antibiotic resistance was established. Escherichia coli, Citrobacter spp, Klebsiella spp among other isolated pathogens formed higher centrality in the network of interaction with antibiotic resistance. The individual E. coli isolates showed a significant difference in the mean ± SD (95% CI) pattern of antibiotic resistance, 2.409±1.205 (1.828–2.990), χ2 = 36.68, p<0.0001. In conclusion, the study reports the interaction of E. coli isolates at UCC hospital and its antibiotic-resistant status between 2013 and 2015. This data forms the baseline information for assessing the current antibiotic status in UCC and its environs.

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Section: Demographic Characteristics Of the Patientsmentioning

confidence: 99%

“…The UPEC antibiotic resistance to cotrimoxazole, ampicillin, nitrofurantoin and fluoroquinolones such as ciprofloxacin and levofloxacin is of major concern [26,27]. The wide range of UPEC resistance to all classes of antibiotics limits the alternative treatment options [28].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-resistant pathogenic bacterial isolates from patients attending the outpatient department of university of Cape Coast hospital, Ghana: A retrospective study between 2013–2015

Asare

Amoah

Coomson

et al. 2022

PLOS Glob Public Health

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“…5 One of the most common illnesses in the community is also a community-acquired UTI. 6 Both Gram-positive and Gram-negative bacteria can cause urinary tract infections. 7 The overuse and abuse of antibiotics are thought to be important contributors to the growth of uropathogenic bacteria with multidrug resistance (MDR) .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Multidrug Resistant <i>Escherichia coli</i> among Urinary Tract Infection Patients in Rawalpindi and Islamabad, Pakistan

Aziz,

Shah,

Alina

et al. 2023

NJLHS

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Background: A common infection known as a urinary tract infection arises when bacteria enter the urethra and infect the urinary system. These germs are usually from the skin or the rectum. Antibiotic resistance is one of the world's most concerning topics due to its severity. This study assessed the trends of antibiotic resistance in E.coli isolates from UTI Individuals. Examining the incidence of uropathogenic E.coli and their multidrug resistance pattern in Islamabad and Rawalpindi. Methods: A 6-month duration-based cross-sectional study was carried out at the microbiology department of Pakistan Institute of Medical Sciences (PIMS) Hospital in Islamabad, Pakistan from July to November 2023. Non-probability sampling, specifically convenient sampling, was used in the study. Collected data was analyzed using SPSS software version 20. Result: The analysis of UTI prevalence by age and gender showed that women (68.3%) were more likely to become infected than males (31.6%), with the incidence of infection being highest in the 31–40 age range. Cefixime resistance was greatest at 95%, followed by ceftriaxone resistance at 88.33% and amoxicillin resistance at 78%. 46.6% of them have more than five medication resistance. Conclusion: The results of the study will help the health department create guidelines for antibiotic prescriptions that will aid medical officers in choosing the appropriate antimicrobial treatment. Education programs that focus on raising knowledge are crucial for preventing E. coli infections and lowering the need for Cefixime and other highly resistant medications. Regular monitoring of antimicrobial susceptibility is necessary.

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Virulence factors, antimicrobial resistance and the relationship between these characteristics in uropathogenic Escherichia coli

et al. 2022

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Multidrug-Resistance Among Uropathogenic Escherichia coli Strains

Abstract:

Cited by 3 publications

References 7 publications

Antibiotic-resistant pathogenic bacterial isolates from patients attending the outpatient department of university of Cape Coast hospital, Ghana: A retrospective study between 2013–2015

Antibiotic-resistant pathogenic bacterial isolates from patients attending the outpatient department of university of Cape Coast hospital, Ghana: A retrospective study between 2013–2015

Prevalence of Multidrug Resistant <i>Escherichia coli</i> among Urinary Tract Infection Patients in Rawalpindi and Islamabad, Pakistan

Virulence factors, antimicrobial resistance and the relationship between these characteristics in uropathogenic Escherichia coli

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