Multidrug resistance reversal effect of DMC derived from buds of <i>Cleistocalyx operculatus</i> in human hepatocellular tumor xenograft model

Hai-ya, Huang; Niu, Jiang-long; Lü, Yanhua

doi:10.1002/jsfa.4551

Cited by 28 publications

(17 citation statements)

References 139 publications

(153 reference statements)

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“…We found that tumor inhibition rate was 31.51%, 43.79%, and 76.29% in the B, C, and D groups, respectively. We tested if the ACNU and HBOT combination showed synergism based on Jin's formula Q = Ea + b/(Ea + Eb – Ea × Eb), where Ea + b, Ea, and Eb are the average effects of the combination treatment, and Q < 0.85 indicates antagonism, 0.85 ≤ Q < 1.15 indicates additivity, and Q ≥ 1.15 indicates synergism . Our Q value was 1.24, indicating ACNU, and combination treatment showed synergistic effect.…”

Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice

Lü

Liu

et al. 2016

Cancer Medicine

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Nimustine (ACNU) has antitumor activities in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are hampered by the hypoxic microenvironment. We examined the combined effects of ACNU and HBO in a GFP transgenic nude mice bearing human glioma model. Mice inoculated with human glioma cells SU3 were randomly divided into the four groups: (A) the control group, (B) the HBOT (HBO therapy) group, (C) the ACNU group, and (D) the HBOT+ACNU group. Tumor size was measured at the indicated time intervals with a caliper; mice were sacrificed 28 days after treatment, and immunohistochemistry staining and western blot analysis were carried out. By the end of the trial, the tumor weights of groups A, B, C, and D were (P < 0.05), 6.03 ± 1.47, 4.13 ± 1.82 (P < 0.05), 2.39 ± 0.25 (P < 0.05), and 1.43 ± 0.38 (P < 0.01), respectively. The expressions of TNF‐α, MMP9, HIF‐α, VEGF, NF‐κB, and IL‐1β were associated with the infiltration of inflammatory cells and the inhibition rate of tumor cells. Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2) in tumor tissues and lower expression levels of HIF‐1α, TNF‐α, IL‐1β, VEGF, MMP9, and NF‐κB.

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Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice

Lü

Liu

et al. 2016

Cancer Medicine

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“…The compound DMC has been isolated from C. operculatus [7], M. serrata [8], and S. samarangense [9]. DMC possessed hepatoprotective [10], cytoprotective [11], anti-inflammatory [12], antifungal, antibacterial [8], anti-TB [13], antiviral [14], antispasmodic [15], antidiarrhoeal [16], antihyperglycaemic [17], anti-MDR [18, 19], and antiapoptotic effect [20]. DMC has been evaluated for its cytotoxic activity on various human cancer cells including liver cancer (SMMC-7721s), HeLa (SPC-A-1, 95-D, and GBC-SD) [7], colon (SW-480) [9], leukemia (K562) [21], colorectal carcinoma (HCT-116 and LOVO) [22], breast (MDA-MB-453), and ovarian [23] cell lines.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

Memon

Ismail

Aisha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Syzygium campanulatum Korth is an equatorial, evergreen, aboriginal shrub of Malaysia. Conventionally it has been used as a stomachic. However, in the currently conducted study dimethyl cardamonin or 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) was isolated from S. campanulatum Korth, leaf extract. The structural characterization of DMC was carried out by making use of various techniques including UV, IR, NMR spectral followed by LC-MS, and X-ray crystallographic techniques. For determining the purity of compound, highly effective techniques including TLC, HPLC, and melting point were used. The cytotoxicity of DMC and three different extracts of S. campanulatum was evaluated against human colon cancer cell line (HT-29) by three different assays. DMC and ethanolic extract revealed potent and dose-dependent cytotoxic activity on the cancer cell line with IC50 12.6 and 90.1 µg/mL, respectively. Quite astonishingly to our knowledge, this is the very first report on S. campanulatum as being a rich source (3.5%) of DMC, X-ray crystallography, and anticancer activity on human colon cancer cells.

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“…Cancer surgery can cause many side effects such as weight loss, fatigue, sickness and loss of appetite depending on the invaded location and size. Several natural products, such as epigallocatechin gallate (EGCG) [ 23 ], 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone [ 24 ], hyperforin and nemorosone [ 25 ], Daickenchuto [ 26 , 27 ] and so forth were reported to be effective against these side effects ( Table 1 ). Stingl et al suggested that epigallocatechin gallate (EGCG) extracted from green tea minimized the risk of metachronous adenomas of the colorectum with colorectal polyp removal surgery [ 23 ].…”

Section: Sequela Of Surgery and Plant Extractsmentioning

confidence: 99%

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

et al. 2020

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Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.

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Multidrug resistance reversal effect of DMC derived from buds of Cleistocalyx operculatus in human hepatocellular tumor xenograft model

Abstract: All results suggested that DMC reverses 5-FU resistance, with a benign side effects profile.

Cited by 28 publications

References 139 publications

Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice

Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice

Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

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