Multidrug-resistant bacteria in travellers hospitalized abroad: prevalence, characteristics, and influence on clinical outcome

Nemeth, Johannes; Ledergerber, Bruno; Preiswerk, Benjamin; Nobile, A.; Karrer, Sigrid; Ruef, C.; Kuster, Stefan P.

doi:10.1016/j.jhin.2012.08.017

Cited by 29 publications

(29 citation statements)

References 28 publications

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“…Prevalence of ESBL-producing Enterobacteriaceae in unaccompanied minors was higher than prevalence rates of patients transferred from hospitals abroad to the University Hospital Zurich, Switzerland, from 1 January 2009 to 30 September 2011: of them, 13.9% were found with ESBL-producing bacteria, while 3MDR GNB prevalence was comparable (7.6% refugees compared with 8.1% patients transferred to the university clinic) [18]. However, prevalence of 3MDR GNB in the unaccompanied minors was still low compared with the data obtained by Reinheimer et al, who tested 143 refugee patients on admission to the University Hospital Frankfurt, Frankfurt/Main, Germany from June to December 2015 and compared the results to data on 1,489 non-refugee patients screened on admission as well.…”

Section: Discussionmentioning

confidence: 68%

Multidrug-resistant bacteria in unaccompanied refugee minors arriving in Frankfurt am Main, Germany, October to November 2015

Heudorf¹,

Krackhardt²,

Karathana³

et al. 2016

Eurosurveillance

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Many refugees arriving in Germany originate or have travelled through countries with high prevalence of multidrug-resistant Gram-negative organisms. Therefore, all unaccompanied refugee minors (<18 years-old) arriving in Frankfurt am Main between 12 October and 6 November 2015, were screened for multidrug-resistant Enterobacteriaceae in stool samples. Enterobacteriaceae with extended spectrum beta-lactamases (ESBL) were detected in 42 of 119 (35%) individuals, including nine with additional resistance to fluoroquinolones (8% of total screened), thus exceeding the prevalences in the German population by far.

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Section: Discussionmentioning

confidence: 68%

Multidrug-resistant bacteria in unaccompanied refugee minors arriving in Frankfurt am Main, Germany, October to November 2015

Heudorf¹,

Krackhardt²,

Karathana³

et al. 2016

Eurosurveillance

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“…20 A Swiss study performed at the University Hospital Zurich detected a prevalence of 13.9% 2MRGN bacterial colonization and 7.9% 3MRGN bacterial colonization among travelers hospitalized abroad. 21 In an Italian sentinel surveillance study analyzing data from 48 Syrian asylum seekers with a median age of 20 years (23% children), 3 of 48 refugees (6.3%) carried MRSA and 11 of 48 (22.9%) carried MRGN. 22 Interestingly, in 4 of 48 refugees (8.3%), Pseudomonas strains (non-P. aeroginosa) were meropenem resistant.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Multidrug-Resistant Organisms in Hospitalized Pediatric Refugees in an University Children’s Hospital in Germany 2015–2016

Tenenbaum

Becker

Lange

et al. 2016

Infect. Control Hosp. Epidemiol.

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objective. To determine the prevalence of multidrug-resistant organisms (MDROs) colonizing in pediatric refugees admitted to a University Children Hospital in Germany.design. Retrospective observational study.setting. General pediatric and pediatric surgery units.patients. In Germany, recommendations for MDRO screening of pediatric refugees were recently published. According to these and institutional recommendations, all hospitalized pediatric refugees were screened for MDROs between October 2015 and March 2016.methods. Using electronic surveillance data, we performed a chart review to identify the prevalence of MDROs among and the clinical diagnoses of pediatric refugees.results. Among 325 patients hospitalized for various causes, most frequently gastroenteritis (30.9%), MDROs were detected in 33.8%. Most of these patients were colonized with multidrug-resistant Gram-negative (MRGN) bacteria (113 isolates), mostly 2MRGN/ESBL (87 isolates); some patients were colonized with methicillin-resistant Staphylococcus aureus (MRSA, 22 isolates); and 1 patient was colonized with vancomycinresistant enterococci (VRE). Among 110 refugee patients, we detected single colonization with an MDRO in 84 patients (76.4%), co-colonization with 2 pathogens in 23 patients (20.9%), and triple colonization in 3 patients (2.7%). However, infections with MDROs occurred in only 3.6% of pediatric refugees. The peak of positive MDRO screening results in 2015 correlated with an increased hospitalization rate.conclusion. Implementation of infection control measures among pediatric refugees is challenging. Due to the high frequency of MDROs in these patients, current screening, isolation, and treatment strategies may have to be adapted.

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“…In fact, it is possible that isolation itself contributes to poor clinical performance. 21 However, the awareness of MDR-GNB colonization can lead to more appropriate antimicrobial drug use, improve patient outcomes, and decrease the emergence of antimicrobial drug resistance. 21 Limitations of the current study include its retrospective design and small sample size.…”

Section: Fig 4 -Gram-negative Bacterial Isolates Detected In the Patmentioning

confidence: 99%

Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria

Costa

Atta

Silva

2014

The Brazilian Journal of Infectious Diseases

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Multidrug-resistant bacteria in travellers hospitalized abroad: prevalence, characteristics, and influence on clinical outcome

Cited by 29 publications

References 28 publications

Multidrug-resistant bacteria in unaccompanied refugee minors arriving in Frankfurt am Main, Germany, October to November 2015

Multidrug-resistant bacteria in unaccompanied refugee minors arriving in Frankfurt am Main, Germany, October to November 2015

Prevalence of Multidrug-Resistant Organisms in Hospitalized Pediatric Refugees in an University Children’s Hospital in Germany 2015–2016

Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria

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