Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria

Abstract

Shock was a predictor of 7- and 30-day mortality, and colonization by multidrug resistant-Gram-negative bacteria was an important risk factor for 30-day mortality.

Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors

“…In our study, the overall incidence of bacteremia during the early transplant period after HDCT/auto-SCT was 7.1%, which was lower than results from adult studies [13,22] and similar to the 7% incidence of overall bacteremia seen 0-30 days post-transplant in a SJCRH cohort [21]. This incidence of bacteremia might be acceptable considering the nature of treatment and the usual prognosis for tumors included in this study; however, the MDR bacteremia might be a significant clinical problem [10,23]. In this study, the incidence of MDR bacteria, particularly ESBL-producing Escherichia coli, appeared to increase over time, and four patients died from MDR bacterial infection.…”

Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways

“…Pseudomonas aeruginosa , an opportunistic Gram-negative bacillus, is a frequent cause of hospital-acquired infections, including ventilator-associated pneumonia 1 and catheter infections in immunocompromised patients. 2 The progressive deterioration of the lungs due to chronic P. aeruginosa infection and the resulting persistent inflammation are currently the main causes of morbidity and mortality in patients with cystic fibrosis. 3 , 4 P. aeruginosa produces factors associated with intracellular communication and extracellular virulence that are globally regulated by well-defined quorum-sensing (QS) systems that determine bacterial pathogenesis.…”

Outcomes of Pediatric Oncology Patients Admitted to An Intensive Care Unit in a Resource-limited Setting

“…However, studies regarding sepsis and outcomes in oncological and nononcological patients are inconsistent. While some studies have suggested that their outcomes may be similar,22,23 others have reported an up to a 30% higher risk of death of septic oncological pediatric patients 11,18,20,21,24. The prognosis may worsen further in patients with neutropaenia, although the available evidence for this is also conflicting 16,22,25–27…”

“…While some studies have suggested that their outcomes may be similar, 22,23 others have reported an up to a 30% higher risk of death of septic oncological pediatric patients. 11,18,20,21,24 The prognosis may worsen further in patients with neutropaenia, although the available evidence for this is also conflicting. 16,22,[25][26][27] In this group of oncological patients, the presence of sepsis and neutropenia were associated with a more than 3-fold increase in mortality (P = 0.0034 and 0.0032, respectively).…”

“…Our study echoes other studies, which demonstrated exponential increases in mortality as the number of organ failures increases. 20,21,[24][25][26][28][29][30][31] In this cohort, patients with two or three organ system failures had a more than 20-fold increase in mortality risk (P = 0.0032). In studies in centers similar to ours, mortality of patients with three or more organ failures have been reported between 60% and 100%.…”