Multidrug-resistant Bacteroides fragilis group on the rise in Europe?

Abstract

We report a case of multidrug-resistance (MDR) in a strain of Bacteroides fragilis from a blood culture and abdominal fluid in a Danish patient. The patient had not been travelling for several years and had not received antibiotics prior to the present case. We also summarize the cases that have been reported to date of MDR B. fragilis group in Europe. As far as we know, a case like this with MDR B. fragilis has not been described in Scandinavia before.

High rate of non-susceptibility to metronidazole and clindamycin in anaerobic isolates: Data from a clinical laboratory from Karachi, Pakistan

“…These strains have been associated with high mortality [22]. Fortunately multidrug resistance was not seen in local isolates, however three strains (one strain each from blood, synovial joint and tissue) were non susceptible to both metronidazole and clindamycin.…”

Identification of antimicrobial resistance genes in multidrug-resistant clinical Bacteroides fragilis isolates by whole genome shotgun sequencing

“…A case report has previously been published for isolate O18 [14] and a case report concerning isolate S01 is being prepared (Ank et al, in preparation).…”

The prevalence of antibiotic resistance genes in Bacteroides fragilis group strains isolated in different European countries

“…The above data might be useful in estimating the likelihood of emergence of the more resistant or multiple-resistant Bacteroides strains. Multiple antibiotic resistant B. fragilis strains pose a serious medical threat and in the past were often isolated in Europe [37]. In addition, since Bacteroides are important members of the normal intestinal microbiota, they are exposed to antibiotics used for various reasons by humans.…”