Multidrug resistant Elizabethkingia meningoseptica bacteremia – Experience from a level 1 trauma centre in India

Govindaswamy, Aishwarya; Bajpai, Vijeta; Trikha, Vivek; Mittal, Samarth; Malhotra, Rajesh; Mathur, Purva

doi:10.5582/irdr.2018.01077

Cited by 26 publications

(25 citation statements)

References 11 publications

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“…All isolates were resistant to commonly used antibiotics. Mortality rate was high (75%) in their study 12 . Our patient had findings similar to the above study.…”

Section: Discussionmentioning

confidence: 72%

Elizabethkingia Meningoseptica: An Emerging Nosocomial Pathogen Causing Septicemia in Critically Ill Patients

Sahu¹,

Balasubramaniam²,

Bipin³

et al. 2019

Indian Journal of Critical Care Medicine

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Elizabethkingia meningoseptica ( E. meningoseptica ), is an opportunistic Gram-negative bacteria, normally found in water and soil, notorious for causing nosocomial infections in extremes of ages and immunocompromised patients. It is now emerging as a serious nosocomial pathogen, intrinsically resistant to several commonly used antibiotics (e.g. beta-lactams, aminoglycosides, carbapenems and colistin etc. and a cause of high mortality in critically ill patients in intensive care units (ICUs). We report the first case of E. meningoseptica sepsis in a 5 month old child after open heart surgery for transposition of great arteries, initially on extracorporeal membrane oxygenation, then prolonged mechanical ventilation, with various invasive devices, inotropes and exposed to broad spectrum antibiotics in our ICU. The case highlights the potential risk factors responsible for E.meningoseptica sepsis. Its unusual pattern of resistance to many commonly used antibiotics makes this organism difficult to treat. How to cite this article Sahu MK, Balasubramaniam U et al . Elizabethkingia Meningoseptica: An Emerging Nosocomial Pathogen Causing Septicemia in Critically Ill Patients. Indian J of Crit Care Med 2019;23(2):104-105.

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“…All isolates were resistant to commonly used antibiotics. Mortality rate was high (75%) in their study 12 . Our patient had findings similar to the above study.…”

Section: Discussionmentioning

confidence: 72%

Elizabethkingia Meningoseptica: An Emerging Nosocomial Pathogen Causing Septicemia in Critically Ill Patients

Sahu¹,

Balasubramaniam²,

Bipin³

et al. 2019

Indian Journal of Critical Care Medicine

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“…Many Elizabethkingia spp. possess two different types of β-lactamases: class A extended-spectrum β-lactamases (ESBLs) and class B metallo-β-lactamases (MBLs) rendering them resistant to all β-lactam including carbapenems, aztreonam, tigecycline, and polymyxin [ 14 ]. Some patients had a history of multidrug-resistant Pseudomonas or Klebsiella infection, which was being treated with colistin prior to acquiring an E. meningosepticum infection.…”

Section: Discussionmentioning

confidence: 99%

A Case Series of Elizabethkingia meningosepticum Bacteremia in the Cancer Population

Lee¹,

Patel²,

Mehra

et al. 2021

Cureus

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Elizabethkingia meningosepticum (E. meningosepticum) is a ubiquitous microorganism previously known as Chryseobacterium meningosepticum. It is emerging as a pathogen responsible for bacteremia in the immunocompromised population, particularly in cancer patients and those with a history of prolonged hospital stay and frequent instrumentations. A retrospective chart review of all cases over 10 years at the Moffitt Cancer Center showed a total of three patients with E. meningosepticum infection. The first patient (history of multiple myeloma) underwent endoscopy complicated by aspiration pneumonia and positive blood culture for E. meningosepticum infection. The second patient (current acute myelogenous leukemia) had neutropenic fever in the setting of a recent chest port infection. Blood culture from the chest port showed E. meningosepticum. The third patient (history of esophageal adenocarcinoma and acute myelogenous leukemia) had a history of recent pneumonia and cellulitis who presented with recurrent neutropenic fever. Blood culture was positive for E. meningosepticum. E. meningosepticum bacteremia has a high 28-day mortality rate (41%). As these three cases illustrate, early identification of the pathogen along with empiric treatment with a fluoroquinolone and/or minocycline is indicated to reduce morbidity and mortality.

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“…E. meningoseptica is associated with prolonged hospitalization and a high risk of mortality. The multidrug-resistant nature of the bacteria is one of the most challenging issues [ 7 , 8 ]. There is no optimal regimen for the management of E. meningoseptica .…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Elizabethkingia meningoseptica Bacteremia After Liver Transplantation

Hoa

Hai

2021

Am J Case Rep

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Patient: Female, 55-year-old Final Diagnosis: Bacteremia Symptoms: Fever Medication: — Clinical Procedure: — Specialty: Critical Care Medicine • Infectious Diseases Objective: Rare disease Background: Elizabethkingia meningoseptica is an emerging pathogen in hospital environments. Immunocompromised individuals have a high risk of infections caused by E. meningoseptica , especially after transplantation. E. meningoseptica is associated with prolonged hospital stays and high mortality. In addition , E. meningoseptica is commonly resistant to many antibiotics used for gram-negative bacterial infections . We introduce the first case of E. meningoseptica bacteremia in a recipient of a liver transplant in Vietnam. Case Report: A 55-year-old woman with end-stage liver disease due to biliary cirrhosis underwent living donor liver transplantation at the 108 Military Central Hospital. On day 3 after transplantation, the patient had an acute cellular rejection, and corticosteroid pulse therapy was used. On day 7 after transplantation, the patient had a fever and an increased white blood cell count and C-reactive protein level. Blood cultures were positive for E. meningoseptica . Intravenous levofloxacin was administered for 10 days. The patient showed an excellent treatment response to the antibiotic therapy and was discharged. Conclusions: E. meningoseptica , a multidrug-resistant gram-negative bacteria, can be considered an emerging pathogen in the hospital environment, especially in patients receiving organ transplants. Early recognition helps physicians to improve patient outcomes.

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Multidrug resistant Elizabethkingia meningoseptica bacteremia – Experience from a level 1 trauma centre in India

Cited by 26 publications

References 11 publications

Elizabethkingia Meningoseptica: An Emerging Nosocomial Pathogen Causing Septicemia in Critically Ill Patients

Elizabethkingia Meningoseptica: An Emerging Nosocomial Pathogen Causing Septicemia in Critically Ill Patients

A Case Series of Elizabethkingia meningosepticum Bacteremia in the Cancer Population

A Rare Case of Elizabethkingia meningoseptica Bacteremia After Liver Transplantation

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