Multidrug-resistant gram-negative organisms: a review of recently approved antibiotics and novel pipeline agents

Provenzani, A; Hospodar, Alexa R; Meyer, André; Vinci, Daniele Leonardi; Hwang, Eun-Mi; Butrus, C. M.; Polidori, Piera

doi:10.1007/s11096-020-01089-y

Cited by 43 publications

(31 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unfortunately, these measures are not sufficient for fighting the resistant bacteria in clinical settings. Possible holistic approaches to cope with this problem could include antibiotic stewardship [ 50 ], developing novel antibiotics [ 51 ], using bacteriophages, and other antibacterial moieties, such as antibodies, synthetic membrane-active agents, or antimicrobial peptides [ 52 , 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Diversity of International High-Risk Clones of Acinetobacter baumannii Revealed in a Russian Multidisciplinary Medical Center during 2017–2019

et al. 2021

View full text Add to dashboard Cite

Acinetobacter baumannii is a dangerous bacterial pathogen possessing the ability to persist on various surfaces, especially in clinical settings, and to rapidly acquire the resistance to a broad spectrum of antibiotics. Thus, the epidemiological surveillance of A. baumannii within a particular hospital, region, and across the world is an important healthcare task that currently usually includes performing whole-genome sequencing (WGS) of representative isolates. During the past years, the dissemination of A. baumannii across the world was mainly driven by the strains belonging to two major groups called the global clones or international clones (ICs) of high risk (IC1 and IC2). However, currently nine ICs are already considered. Although some clones were previously thought to spread in particular regions of the world, in recent years this is usually not the case. In this study, we determined five ICs, as well as three isolates not belonging to the major ICs, in one multidisciplinary medical center within the period 2017–2019. We performed WGS using both short- and long-read sequencing technologies of nine representative clinical A. baumannii isolates, which allowed us to determine the antibiotic resistance and virulence genomic determinants, reveal the CRISPR/Cas systems, and obtain the plasmid structures. The phenotypic and genotypic antibiotic resistance profiles are compared, and the possible ways of isolate and resistance spreading are discussed. We believe that the data obtained will provide a better understanding of the spreading and resistance acquisition of the ICs of A. baumannii and further stress the necessity for continuous genomic epidemiology surveillance of this problem-causing bacterial species.

show abstract

Section: Discussionmentioning

confidence: 99%

Diversity of International High-Risk Clones of Acinetobacter baumannii Revealed in a Russian Multidisciplinary Medical Center during 2017–2019

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Murepavadin ( Figure 1 ) demonstrated excellent in vitro efficacy against >1000 clinical MDR P. aeruginosa strains before successfully completing phases I and II clinical trials [ 62 ]. Investigation into intravenous administration was halted at phase III due to increased hepatic toxicity [ 63 ]. However, preclinical research into inhaled murepavadin is ongoing.…”

Section: Outer Membranementioning

confidence: 99%

Overcoming Intrinsic and Acquired Resistance Mechanisms Associated with the Cell Wall of Gram-Negative Bacteria

et al. 2020

View full text Add to dashboard Cite

The global increase in multi-drug-resistant bacteria is severely impacting our ability to effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired resistance mechanisms are heightened by their unique cell wall structure. The cell wall, while being a target of some antibiotics, represents a barrier due to the inability of most antibacterial compounds to traverse and reach their intended target. This means that its composition and resulting mechanisms of resistance must be considered when developing new therapies. Here, we discuss potential antibiotic targets within the most well-characterised resistance mechanisms associated with the cell wall in Gram-negative bacteria, including the outer membrane structure, porins and efflux pumps. We also provide a timely update on the current progress of inhibitor development in these areas. Such compounds could represent new avenues for drug discovery as well as adjuvant therapy to help us overcome antibiotic resistance.

show abstract

“…In fact, accompanied by antibiotic resistance, the search for novel antibacterial agents, especially natural occurring alternatives, remains an ongoing concern. 146,147 The diterpenoids from the aerial part of S. trifolia would bring us close to new nutraceuticals and pharmaceuticals with antibacterial properties, which also deserve more attention.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Sagittaria trifolia tuber: bioconstituents, processing, products, and health benefits

Yang

Wang

et al. 2020

J Sci Food Agric

View full text Add to dashboard Cite

Sagittaria trifolia is an aquatic plant that is distributed worldwide. The edible tuber part of S. trifolia is a very common and popular vegetable in China. The aim of the present review is to discuss the discovery of nutraceuticals from S. trifolia tuber by reviewing its major constituents, food processing, food products, and health-promoting benefits. Sagittaria trifolia tuber comprises a series of nutritional and bioactive constituents, including dietary fibers, amino acids, minerals, starches, non-starch polysaccharides, diterpenoids, colchicine, phenols, and organic acids. Food processing affects its flavor, biocomponents, and bioactivity. Numerous S. trifolia tuber-based food products and nutraceuticals have been developed, but new categories of products and the anticipated functions still need to be explored. The non-starch polysaccharides could be the central ingredients that contribute to the plant's antioxidant, hepatoprotective, hypoglycemic, lipid-regulating, and immunostimulatory properties. Of these, antioxidant and hepatoprotective effects have been thoroughly investigated. Procedures for the extraction and purification of polysaccharides influence their health-promoting actions. Overall, S. trifolia tuber is an underutilized aquatic vegetable species that is an emerging subject for nutraceutical research.

show abstract

Multidrug-resistant gram-negative organisms: a review of recently approved antibiotics and novel pipeline agents

Cited by 43 publications

References 20 publications

Diversity of International High-Risk Clones of Acinetobacter baumannii Revealed in a Russian Multidisciplinary Medical Center during 2017–2019

Diversity of International High-Risk Clones of Acinetobacter baumannii Revealed in a Russian Multidisciplinary Medical Center during 2017–2019

Overcoming Intrinsic and Acquired Resistance Mechanisms Associated with the Cell Wall of Gram-Negative Bacteria

Sagittaria trifolia tuber: bioconstituents, processing, products, and health benefits

Contact Info

Product

Resources

About