Multidrug-resistant <i>Acinetobacter baumannii</i> infection in lung transplant recipients: risk factors and prognosis

Oh, Dong Hyun; Kim, Yong Chan; Kim, Eun Jin; Jung, In Young; Jeong, Su Jin; Kim, Song Yee; Park, Moo Suk; Kim, Anes; Lee, Jin Gu; Paik, Hyo Chae

doi:10.1080/23744235.2018.1556400

Cited by 20 publications

(18 citation statements)

References 30 publications

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“…The prognostic value of low serum albumin levels has been demonstrated not only for the development and complications of acute viral, bacterial, and fungal infections [ 95 ], but also for infectious complications in chronic conditions including malignant diseases [ 66 , 96 ], chronic inflammatory diseases [ 97 , 98 ], diabetes [ 95 ], hemodialysis [ 99 ], and solid organ transplantation [ 100 ]. In chronic infectious diseases, hypoalbuminemia is associated with disease reactivation/recurrence and secondary infections [ 101 , 102 , 103 ].…”

Section: Hypoalbuminemia and Prognosis In Infectionsmentioning

confidence: 99%

Hypoalbuminemia as Surrogate and Culprit of Infections

Wiedermann¹

2021

IJMS

155

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Hypoalbuminemia is associated with the acquisition and severity of infectious diseases, and intact innate and adaptive immune responses depend on albumin. Albumin oxidation and breakdown affect interactions with bioactive lipid mediators that play important roles in antimicrobial defense and repair. There is bio-mechanistic plausibility for a causal link between hypoalbuminemia and increased risks of primary and secondary infections. Serum albumin levels have prognostic value for complications in viral, bacterial and fungal infections, and for infectious complications of non-infective chronic conditions. Hypoalbuminemia predicts the development of healthcare-associated infections, particularly with Clostridium difficile. In coronavirus disease 2019, hypoalbuminemia correlates with viral load and degree of acute lung injury and organ dysfunction. Non-oncotic properties of albumin affect the pharmacokinetics and pharmacodynamics of antimicrobials. Low serum albumin is associated with inadequate antimicrobial treatment. Infusion of human albumin solution (HAS) supplements endogenous albumin in patients with cirrhosis of the liver and effectively supported antimicrobial therapy in randomized controlled trials (RCTs). Evidence of the beneficial effects of HAS on infections in hypoalbuminemic patients without cirrhosis is largely observational. Prospective RCTs are underway and, if hypotheses are confirmed, could lead to changes in clinical practice for the management of hypoalbuminemic patients with infections or at risk of infectious complications.

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Section: Hypoalbuminemia and Prognosis In Infectionsmentioning

confidence: 99%

Hypoalbuminemia as Surrogate and Culprit of Infections

Wiedermann¹

2021

IJMS

155

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“…Dong Hyun Oh and his colleagues found that hypoalbuminemia is a risk factor for AB infection after lung transplantation. [26] In our study, open fracture account for a high proportion. Open fractures increase the risk of wound contamination, and the Eastern Association for the Surgery of Trauma (EAST) recommends that perioperative prevention of type III open fractures with antibiotics that cover gram-negative bacteria.…”

Section: Risk Factorsmentioning

confidence: 55%

Microbiology Characteristics and Risk Factors of Surgical Site Infection in Limb Fractures: a Single-center Retrospective Study

Luo

Chen

Zhang

et al. 2021

Preprint

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Background: Limb fractures were becoming more common, and internal fixation increased the risk of surgical site infection. The purpose of this study was to identified risk factors for surgical site infection and the factors that affected the microbiological characteristics.Material and methods: Data from patients with limb fractures who received internal fixation between January 2010 and January 2020 were included. Univariate and multivariate logistic analyses were performed to determine independent risk factors.Results: A total of 4479 patients were identified and 187 (4.18%) patients developed surgical site infections (SSI). Staphylococcus aureus (25.1%) was the most common bacteria, followed by Coagulase negative Staphylococcus (18.8%) and Acinetobacter baumannii (12.0%). Multiple regression analysis revealed that low total protein (OR, 4.066; 95% CI, 1.217-13.583) and high white blood cell count (OR, 3.133; 95% CI, 1.291-7.605) were risk factors for gram-negative bacteria infection. Five risk factors were identified to be independently associated with the development of SSIs, including current smoking (OR, 2.923; 95% CI, 1.294-6.599), high-energy injury (OR, 2.816; 95% CI, 1.368-5.799), femoral fracture, tibia and fibula fracture, vascular injury at the fracture site (OR, 10.284; 95% CI, 2.506-42.199), skin contusin at the fracture site (OR, 3.348; 95% CI, 1.304-8.574), hypohemoglobin (OR, 2.991; 95% CI, 1.422-6.292).Conclusion: Preoperative preventative measures should be taken in patients at high risk to reduce the incidence of SSIs.

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“…Some studies found that hypoalbuminemia before transplantation was an important risk factor for multidrugresistant A. baumannii infection in patients with lung transplantation. 15 Hypoalbuminemia was also found to be an independent risk factor for respiratory tract infection of A. baumannii in ICU. 46 Hypoalbuminemia is generally considered as an indicator of weakness and homeostasis instability in the body.…”

Section: Dovepressmentioning

confidence: 93%

“…12 However, most of the current studies focused on the analysis of risk factors for A. baumannii infection or death from A. baumannii infection in a single-system infection. 11,[13][14][15][16] Various infections caused by A. baumannii and death were observed in a large number of critically ill patients. Therefore, early detection of patients with high-risk factors for death and effective interventions can significantly reduce complications, thus improving the prognosis of patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Development and Validation of a Model for Predicting the Risk of Death in Patients with Acinetobacter baumannii Infection: A Retrospective Study</p>

Zhang¹,

Zhao²,

Zheng³

et al. 2020

IDR

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This study aimed to develop and validate a personalized prediction model of death risk in patients with Acinetobacter baumannii (A. baumannii) infection and thus guide clinical research and support clinical decision-making. Patients and Methods: The development group is comprised of 350 patients with A. baumannii infection admitted between January 2013 and December 2015 in The First Affiliated Hospital of Anhui Medical University. Further, 272 patients in the validation group were admitted between January 2016 and December 2018. The univariate and multivariate logistic regression analyses were used to determine the independent risk factors for death with A. baumannii infection. The nomogram prediction model was established based on the regression coefficients. The discrimination of the proposed prediction model was evaluated using the area under the curve (AUC) of the receiver operating characteristic (ROC) curves and decision curve analysis (DCA). The calibration diagram was used to evaluate the calibration degree of this model. Results: The infectious source, carbapenem-resistant A. baumannii (CRAB), hypoalbuminemia, Charlson comorbidity index (CCI), and mechanical ventilation (MV) were independent risk factors for death. The AUC of the ROC curve of the two groups was 0.768 and 0.792, respectively. The net income was higher when the probability was between 30% and 80%, showing a strong discrimination capacity of the proposed model. The calibration curve swung around the 45° oblique line, indicating a high degree of calibration. Conclusion: The proposed model helped predict the risk of death from A. baumannii infection, improve the early identification of patients with a higher risk of death, and guide clinical treatment.

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Multidrug-resistant Acinetobacter baumannii infection in lung transplant recipients: risk factors and prognosis

Cited by 20 publications

References 30 publications

Hypoalbuminemia as Surrogate and Culprit of Infections

Hypoalbuminemia as Surrogate and Culprit of Infections

Microbiology Characteristics and Risk Factors of Surgical Site Infection in Limb Fractures: a Single-center Retrospective Study

<p>Development and Validation of a Model for Predicting the Risk of Death in Patients with Acinetobacter baumannii Infection: A Retrospective Study</p>

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