Multidrug-Resistant <i>Candida auris</i> Infections in Critically Ill Coronavirus Disease Patients, India, April–July 2020

Chowdhary, Anuradha; Tarai, Bansidhar; Singh, Ashutosh; Sharma, Amit

doi:10.3201/eid2611.203504

Cited by 274 publications

(328 citation statements)

References 14 publications

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“…Moreover, we postulated a negative impact of COVID-19 on antimicrobial stewardship programs, an issue reported in a speculative manner in various reviews and editorials. To the best of our knowledge, only one real-life report describes the acquisition of CR-Kp colonization among COVID-19 patients [15], while two centers reported an increase in C. auris infections in COVID-19 patients [16,17]. We supposed that the main drivers of an increase in antimicrobial resistance during COVID-19 in our hospital were the use of broad-spectrum antimicrobials and horizontal spread of resistant strains.…”

Section: Discussionmentioning

confidence: 87%

Spread of Carbapenem-Resistant Gram-Negatives and Candida auris during the COVID-19 Pandemic in Critically Ill Patients: One Step Back in Antimicrobial Stewardship?

et al. 2021

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The possible negative impact of severe adult respiratory distress caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19) on antimicrobial stewardship and infection control has been postulated, but few real-life data are available. The aim of this study was to report our experience with colonization/infection of carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Klebsiella pneumoniae (CR-Kp) and Candida auris among critically ill COVID-19 patients admitted to the intensive care unit (ICU). All COVID-19 patients admitted to the ICUs at San Martino Policlinico Hospital–IRCCS in Genoa, Italy, were screened from 28 February to 31 May 2020. One-hundred and eighteen patients admitted to COVID-19 ICUs were included in the study. Among them, 12 (10.2%) became colonized/infected with CRPA, 6 (5.1%) with C. auris and 2 (1.6%) with CR-Kp. All patients with CRPA received prior treatment with meropenem, and in 11 (91.7%) infection was not preceded by colonization. Four patients (66.7%) developed C. auris candidemia. A significant spread of resistant pathogens was observed among critically ill COVID-19 patients. Dedicated strategies are warranted to prevent horizontal spread and maintain effective antimicrobial stewardship programs in the setting of COVID-19 care.

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Section: Discussionmentioning

confidence: 87%

Spread of Carbapenem-Resistant Gram-Negatives and Candida auris during the COVID-19 Pandemic in Critically Ill Patients: One Step Back in Antimicrobial Stewardship?

et al. 2021

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“…Chowdhary et al. [ 6 ] theorized that transmission of COVID-19-associated C. auris by health personnel is unlikely because of the use of PPE. The 15 isolates of C. auris were non-susceptible to AMB and FLU, which are the main antifungal drugs used in most of the hospitals in Mexico.…”

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confidence: 99%

Outbreak of Candida auris infection in a COVID-19 hospital in Mexico

Villanueva-Lozano

Treviño-Rangel

González

et al. 2021

Clinical Microbiology and Infection

151

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“…Several studies-from, in particular, Germany, Italy and the US-have reported outbreaks or an increase in infections with and/or acquisition of multidrug-resistant bacteria during the COVID-19 pandemic [9][10][11][12]. Further studies have reported cases of antimicrobial-resistant invasive fungal infections in COVID-19 patients [13,14], and one case of azole-resistant Aspergillus spp. infection in an immunocompetent COVID-19 patient [15].…”

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confidence: 99%