Multidrug-resistant Shigella sonnei carrying the plasmid-mediated mcr -1 gene in China

Ma, Qiuxia; Huang, Yong; Wang, Jian; Xu, Xuebin; Hawkey, Jane; Yang, Chaojie; Liang, Beibei; Hu, Xin; Wu, Fuli; Yang, Xiaoxia; Wang, Jinyan; Li, Rongrui; Xie, Jing; Jia, Leili; Wang, Ligui; Hao, Rongzhang; Tong, Yigang; Holt, Kathryn E.; Qiu, Shaofu; Sun, Yansong; Song, Hongbin

doi:10.1016/j.ijantimicag.2018.02.019

Cited by 15 publications

(14 citation statements)

References 38 publications

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“…The mechanism of resistance of mcr-1 is produced by a phosphatidylethanolamine transferase, leading to modification of lipid A present as a result of addition of phosphoethanolamine to lipid A in cell membranes of Gram-negative bacteria, resulting in more cationic LPSs and lower affinity for colistin and related polymyxins and consequently reduced antimicrobial activity 117. The presence of mcr-1 in Shigella isolates leads to a four- to eightfold increase in the MIC of polymyxin B 118Figure 3).…”

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

“…114 ESBL-encoding genes or other resistance genes might coexist with it. Also, plasmid-mediated colistin-resistant S. flexneri isolates recovered from animal feces on a farm showed that it might be circulated via the fecal–oral route, at least between animals on that farm, and possibly distributed via the food-production network 118. In most reports, mcr-1 is known to be the only resistance gene for related plasmids, indicating that selective pressure associated with polymyxin is responsible for mcr-1 acquisition 114,118.…”

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

“…It means that other plasmids conferring MDR phenotypes can be achieved from resistant S. flexneri strains. Mobile elements, such as IS and integrons, could also help isolates acquiring other resistance elements from the environment 118. A novel transposon, Tn 6390 has been detected in S. flexneri C960, in which two copies of ISApl1 bracketed to the mcr-1 gene play a pivotal role in transposition of mcr-1 118.…”

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

“…Mobile elements, such as IS and integrons, could also help isolates acquiring other resistance elements from the environment 118. A novel transposon, Tn 6390 has been detected in S. flexneri C960, in which two copies of ISApl1 bracketed to the mcr-1 gene play a pivotal role in transposition of mcr-1 118. Recently, mcr-1 was identified in S. sonnei isolates from Shanghai (2010–2012) with polymyxin B resistance (MIC 4–8 μg/mL) 118…”

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

“…A novel transposon, Tn 6390 has been detected in S. flexneri C960, in which two copies of ISApl1 bracketed to the mcr-1 gene play a pivotal role in transposition of mcr-1 118. Recently, mcr-1 was identified in S. sonnei isolates from Shanghai (2010–2012) with polymyxin B resistance (MIC 4–8 μg/mL) 118Figure 3Structure of genes surrounding mcr-1 in S. flexneri.…”

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

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Shigella: Antibiotic-Resistance Mechanisms And New Horizons For Treatment

Ranjbar¹,

Farahani²

2019

IDR

133

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Shigella spp. are a common cause of diarrheal disease and have remained an important pathogen responsible for increased rates of morbidity and mortality caused by dysentery each year around the globe. Antibiotic treatment of Shigella infections plays an essential role in reducing prevalence and death rates of the disease. However, treatment of these infections remains a challenge, due to the global rise in broad-spectrum resistance to many antibiotics. Drug resistance in Shigella spp. can result from many mechanisms, such as decrease in cellular permeability, extrusion of drugs by active efflux pumps, and overexpression of drug-modifying and -inactivating enzymes or target modification by mutation. Therefore, there is an increasing need for identification and evolution of alternative therapeutic strategies presenting innovative avenues against Shigella infections, as well as paying further attention to this infection. The current review focuses on various antibiotic-resistance mechanisms of Shigella spp. with a particular emphasis on epidemiology and new mechanisms of resistance and their acquisition, and also discusses the status of novel strategies for treatment of Shigella infection and vaccine candidates currently under evaluation in preclinical or clinical phases.

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Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

Section: Drug-resistance Mechanisms In Shigella Sppmentioning

confidence: 99%

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Shigella: Antibiotic-Resistance Mechanisms And New Horizons For Treatment

Ranjbar¹,

Farahani²

2019

IDR

133

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Genetic diversity and antibiotic resistance of Shigella spp. isolates from food products

Pakbin

Amani

Allahyari

et al. 2021

Food Science & Nutrition

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The emergence of multidrug-resistant Shigella is a significant threat to global public health. Limited studies have investigated the incidence, antimicrobial susceptibility, and genetic diversity of Shigella isolated from food products. Conventional culturebased, serologic, molecular, disk diffusion, PCR, and RAPD-PCR methods were used to determine the prevalence rate, phenotypic and genotypic antibiotic resistance profile, and genetic diversity of the Shigella isolates from food samples including vegetable salad, ground meat, and raw cow's milk (405 samples). The prevalence rate of Shigella in food samples was 4.44%. The incidence of S. sonnei (3.7%) was higher than that of S. flexneri (0.74%). S. dysenteriae and S. boydii were not detected in food samples examined. Also, no Shigella were recovered from raw cow's milk. This study showed that the Shigella isolates were resistant to sulfamethoxazole/trimethoprim (83.3%), amoxicillin (66.6%), streptomycin (66.6%), tetracycline (61.1%), ampicillin (50%), amoxicillin-clavulanic acid (50%), azithromycin (50%), and chloramphenicol (50%) and completely sensitive to cefoxitin, cefepime, amikacin, and gentamicin.All Shigella isolates were multidrug-resistant. We detected bla SHV resistance gene in all isolates; however, no isolate harbored bla TEM gene. RAPD-PCR categorized the Shigella isolates into five main clusters. The highest antibiotic resistance was observed in the isolates of cluster R4. The finding of this study also indicated an association between antimicrobial resistance profiles and genotyping properties of the isolates. Novel food monitoring systems, including surveillance of multidrug-resistant foodborne pathogens, especially in developing countries, are required to control the foodborne diseases.

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Problematic Groups of Multidrug-Resistant Bacteria and Their Resistance Mechanisms

Kohler

Vaishampayan

Grohmann

2019

Antibacterial Drug Discovery to Combat MDR

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Multidrug-resistant Shigella sonnei carrying the plasmid-mediated mcr -1 gene in China

Cited by 15 publications

References 38 publications

<p><em>Shigella</em>: Antibiotic-Resistance Mechanisms And New Horizons For Treatment</p>

<p><em>Shigella</em>: Antibiotic-Resistance Mechanisms And New Horizons For Treatment</p>

Genetic diversity and antibiotic resistance of Shigella spp. isolates from food products

Problematic Groups of Multidrug-Resistant Bacteria and Their Resistance Mechanisms

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