Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes

Tachibana, Koji; Tang, Nina; Urakami, Hitoshi; Kajita, Ai; Kobashi, Mina; Nomura, Hayato; Sasakura, Minori; Sugihara, Satoru; Jiang, Fan; Tomonobu, Nahoko; Sakaguchi, Masakiyo; Ouchida, Mamoru; Morizane, Shin

doi:10.3390/ijms222312659

Cited by 7 publications

(8 citation statements)

References 42 publications

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“…The interleulin-12 cytokine IL-39 is known to mediate inflammatory response and is implicated in immunopathogenesis of diseases such as psoriasis (17), systemic lupus erythematosus (4), myocardial infarction (18) and hepatocyte necrosis (19). This study indicated an increased level of IL-39 in RA patients (G1-G3) compared to healthy control assuming significance as results show that IL-39 probably contributes to inflammatory response in RA as seen in other disease studied.…”

Section: Discussionsupporting

confidence: 50%

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Mohammed

Alosami²,

Alubadi³

2022

Biomedicine

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Introduction and Aim: The pro-inflammatory cytokine IL-39, a member of the IL-12 family plays a key role in the inflammatory response by modulating immune cell activity and inflammation. A literature search shows no study undertaken for the effect of IL-39's on arthritis so far. Hence, the purpose of this study was to investigate the role of IL-39 in rheumatoid arthritis. Materials and Methods: This study involved 80 patients with rheumatoid arthritis registered at the Rheumatology Clinic at Baghdad teaching hospital. The patients were divided into three groups based on treatments received. Group 1 included patients who were not on any treatment for arthritis, Group 2 with patients on hydroxychloroquine and or prednisone treatment, and Group 3 that received Enbrel® (etanercept) and HUMIRA® (adalimumab) treatment for rheumatoid arthritis. A control group was included in the study. Patients in all groups were assessed for their serum IL-39 concentration, C - reactive protein, Anti-cyclic citrullinated peptide antibody (ACCP) and ESR. Results: The patient age and BMI were not significantly different between the groups receiving treatment for Rheumatoid arthritis. A significant increase in the interleukin 39 concentration was observed in treatment groups (G1, G2, G3) as compared to normal healthy controls regardless of whether they were positive or negative for the anti-CCP test. Conclusion: This study showed that the serum interleukin IL-39 levels significantly increased in patients diagnosed with rheumatoid arthritis thus suggesting that IL-39 could be considered as a potential inflammatory biomarker of RA.

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Section: Discussionsupporting

confidence: 50%

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Mohammed

Alosami²,

Alubadi³

2022

Biomedicine

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“…Quantitative analysis showed a significant increase in epidermal thickness in HFD-fed Apoe −/− mice (Figure 2d). Exacerbated inflammatory skin changes in the HFD-fed Apoe −/− mice were confirmed by the increased expression of IL-23p19, signal transducer and activator of transcription-3 (STAT3), and phospho-STAT3 in the epidermis of inflamed skin (Figure S1), which are known to be activated in psoriatic skin [19,20]. Collectively, these data indicate that the combination of obesity and dyslipidemia triggered more intense psoriatic inflammation than obesity or dyslipidemia alone.…”

Section: High-fat-diet-induced Obesity and Apoe-deficiency-induced Dy...mentioning

confidence: 75%

Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation

Ikeda

Morizane

Akagi

et al. 2022

IJMS

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Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis. To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal keratinocytes (NHEKs), we used wild-type and Apoe-deficient dyslipidemic mice, and administered a high-fat diet for 10 weeks to induce obesity. Imiquimod was applied to the ear for 5 days to induce psoriatic dermatitis. To examine the innate immune responses of NHEKs, we cultured and stimulated NHEKs using IL-17A, TNF-α, palmitic acid, and leptin. We found that obesity and dyslipidemia synergistically aggravated psoriatic dermatitis associated with increased gene expression of pro-inflammatory cytokines and chemokines. Treatment of NHEKs with palmitic acid and leptin amplified pro-inflammatory responses in combination with TNF-α and IL-17A. Additionally, pretreatment with palmitic acid and leptin enhanced IL-17A-mediated c-Jun N-terminal kinase phosphorylation. These results revealed that obesity and dyslipidemia synergistically exacerbate psoriatic skin inflammation, and that metabolic-disorder-associated inflammatory factors, palmitic acid, and leptin augment the activation of epidermal keratinocytes. Our results emphasize that management of concomitant metabolic disorders is essential for preventing disease exacerbation in patients with psoriasis.

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“…15 However, increasing evidence shows that neutrophils are the most abundant cell type producing IL-17 in psoriatic lesions. 27,28 Studies have demonstrated that IL-23 can specifically promote the transcription-level production of IL-17A, IL-17F, and IL-22 by neutrophils. IL-23 induces to produce IL-17 through the STAT3-dependent RoRγt and BATF pathways by neutrophil.…”

Section: Il-17 Produced By Neutrophilsmentioning

confidence: 99%

“…90 Among them, LL-37 is recognized as the main autoantigen of psoriasis, 91 which ultimately induces Th17 cells to produce IL-17 92 through a series of reactions. Increasing evidence shows that KCs can produce IL-23, 19,28,93 triggering a cascade reaction (Figure 1). One of the pathways leading to the release of IL-23 by KCs is the activation of TLR3, which can be dependent on double-stranded RNA (dsRNA).…”

Section: The Interaction Of Neutrophils With Other Immune Cellsmentioning

confidence: 99%

“…In the pathogenesis of psoriasis, the Th17 cell is considered to be the main producer of IL‐17 15 . However, increasing evidence shows that neutrophils are the most abundant cell type producing IL‐17 in psoriatic lesions 27,28 . Studies have demonstrated that IL‐23 can specifically promote the transcription‐level production of IL‐17A, IL‐17F, and IL‐22 by neutrophils.…”

Section: Introductionmentioning

confidence: 99%

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Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis

Wang

Shi

2023

Skin Research and Technology

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Background: Psoriasis is an immune-mediated chronic inflammatory disease, and currently it is widely believed that the IL-23/IL-17 axis and Th17 cells play a critical and central role. However, increasing evidence suggests that neutrophils may interact with a variety of immune cells to play an indispensable role in psoriasis. Materials and methods:We searched the recent literature on psoriasis and neutrophils through databases such as PubMed and CNKI, and summarized the findings to draw conclusions. Results: Neutrophils can promote the development of psoriasis by secreting IL-23, IL-17, and cytokines with TH17 cell chemotaxis. Activated keratinocytes (KCs) can attract and activate neutrophils, induce the formation of neutrophil extracellular traps (NETs).KCs can also expose self-antigens which lead to strong autoimmune reactions. The granule proteins secreted by activated neutrophils can activate IL-36, which converts vulgaris psoriasis to generalized pustular psoriasis (GPP). Conclusion:The function of neutrophils components and the interaction between neutrophils and immune cells play an essential role in the pathogenesis of psoriasis. The aim is to provide a theoretical basis for the exploration of targeted clinical treatments and fundamental research on the pathogenesis of psoriasis.

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Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes

Cited by 7 publications

References 42 publications

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation

Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis

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