Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury

Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease

“…These cells are thought to originate from the cranial neural crest, which expresses early markers for both MSCs and neural stem cells [26][27][28], and can differentiate into functional neurons and oligodendrocytes under the appropriate conditions [28][29][30]. The engraftment of these dental pulp stem cells promotes the functional recovery from various acute and chronic CNS insults through paracrine mechanisms that activate endogenous tissuerepairing activities [28,[31][32][33][34][35][36]. Here, we examined the therapeutic benefits of SHED-CM for mouse AD-like model.…”

Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats

“…They are thought to originate from the cranial neural crest, which expresses early markers for both MSCs and neuroectodermal stem cells (Gronthos et al, 2000a;Miura et al, 2003b) and can differentiate into functional neurons (Gronthos et al, 2000a;Miura et al, 2003b) and oligodendrocytes (Sakai et al, 2012) under appropriate conditions. When engrafted, these dental pulp-derived stem cells promote functional recovery from various acute and chronic CNS insults through both cell replacement and paracrine mechanisms (Yamamoto et al, 2014;Young et al, 2013).…”

Differentiation of stem cells derived from carious teeth into dopaminergic‐like cells

“…More recently, healthy dental pulps are seen to be an excellent cell source for neuro-ectoderm related studies especially towards neurogenesis such as dopaminergic (DAergic)-like cells (Govindasamy et al 2010, Wang et al 2010, Kanafi et al 2013, Osathanon et al 2014, Varga & Gerber 2014, Yamamoto et al 2014. The aim of the present study was to investigate whether DPSCs from carious teeth were able to differentiate into neuronal lineage especially towards DAergic-like cells, which has yet to be reported.…”