Multifactorial Determination of Hypertensive Nephroangiosclerosis

Tylicki, Leszek; Rutkowski, Bolesław; Hörl, Walter H.

doi:10.1159/000068698

Cited by 18 publications

(9 citation statements)

References 177 publications

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“…This is indirectly suggested by the fact that hypertensive patients with hyperinsulinemia excrete greater amounts of urinary albumin [33]. It is believed that the nature of nephrosclerosis is heterogeneous, and other factors beside blood pressure are implicated in the development and progression of nephrosclerosis [34]. The mechanism by which insulin can induce renal injury is not completely clear; however, the deleterious influence of insulin on injury and dysfunction of endothelial cells is strongly suggested.…”

Section: Close Links Between Preeclampsia Insulin Resistance and Nementioning

confidence: 99%

Short- and long-term prognosis of blood pressure and kidney disease in women with a past history of preeclampsia

et al. 2008

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Little research has been conducted into the long-term effects of preeclampsia, despite its frequent occurrence. The aim of this review is to examine the association between preeclampsia and the development of hypertension and kidney diseases later in life. To achieve this aim, we evaluated three retrospective studies conducted in our department. In the first study, 52 women who suffered from preeclampsia during their first pregnancy were followed for 2 years after delivery for any long-term effects upon blood pressure. In the second study, we evaluated HOMA-R, pulse wave velocity and augmentation index in groups of 48 postmenopausal women with a past history of preeclampsia and 204 postmenopausal women without a past history of preeclampsia. In the third study, we examined the association between a past history of preeclampsia and chronic kidney disease based on biopsy in 127 postmenopausal women. From the first study, although there were no significant differences in age, blood pressure at the onset of preeclampsia, the levels of proteinuria and the birth weight of the child between women who remained hypertensive and those who became normotensive, body mass index was significantly larger in women who remained hypertensive compared to those who were normotensive. In the second study, we found that women with a past history of preeclampsia exhibited insulin resistance combined with reduced vascular elasticity. In the third study, of 32 patients with a past history of preeclampsia, 12 patients exhibited focal segmental glomerulosclerosis, 10 exhibited IgA nephropathy and 10 exhibited nephrosclerosis. In contrast, of the women without a past history of preeclampsia, 26 patients exhibited IgA nephropathy, 20 exhibited a minimal change in nephritic syndrome, 6 exhibited nephrosclerosis, 6 exhibited membranous nephropathy, 5 exhibited lupus nephritis, 5 exhibited diabetic nephropathy, and 27 exhibited various nephropathies. None of the women without a past history of preeclampsia exhibited focal segmental glomerulosclerosis. Taken together with previous results, these findings suggest that hypertension and chronic kidney disease in postmenopausal women are closely associated with a past history of preeclampsia.

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Section: Close Links Between Preeclampsia Insulin Resistance and Nementioning

confidence: 99%

Short- and long-term prognosis of blood pressure and kidney disease in women with a past history of preeclampsia

et al. 2008

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“…1 There is no doubt, however, that other factors besides elevated blood pressure contribute to the development and progression of hypertensive nephropathy (HN). 2 To shed more light on this issue, we performed a case-control, cross-sectional study to identify determinants of renal complications of essential hypertension correlating them with surrogate markers of kidney injury in hypertensives presenting microalbuminuria or proteinuria. To assess the enhancement of kidney involvement, von Willebrand factor (vWf) plasma activity, albuminuria and N-acetyl-b-D-glucosaminidase (NAG) excretion were determined as markers of endothelial, glomerular and tubular injury, respectively.…”

mentioning

confidence: 99%

Multifactoral analysis of determinators for renal injury in essential hypertension

et al. 2005

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“…49 It is believed that the nature of nephrosclerosis is heterogeneous and factors other than BP are implicated in the development and progression of nephrosclerosis. 50 The mechanism by which insulin can induce renal injury is not completely clear, the deleterious influence of insulin on injury and dysfunction of endothelial cells has been shown. In addition to this, an increase of cholesterol and triglyceride synthesis as a consequence of hyperinsulinemia might promote vascular injury.…”

Section: Role Of Estrogen In Ckdmentioning

confidence: 99%

Chronic kidney disease in postmenopausal women

Suzuki

Kondo

2011

Hypertens Res

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Menopause is derived from the Greek words men (month) and pauses (cessation) and means permanent cessation of menstruation after the loss of ovarian activity. Chronic kidney disease (CKD) has recently been associated with cardiovascular events in several studies. CKD patients have a heavy burden of traditional cardiovascular risk factors in addition to a range of nontraditional risk factors such as inflammation and abnormal metabolism of calcium and phosphate. In this review, the association of CKD and cardiovascular disease (CVD), as well as of osteoporosis in postmenopausal women is discussed. CKD mineral and bone disorder, characterized by disturbances of calcium/phosphate/parathyroid hormone, bone abnormalities and vascular and soft tissue calcification, is highly prevalent in CKD and is a strong, independent predictor of bone fracture, CVD and death. Estrogen has been shown to: (a) decrease the expression of angiotensin type 1 receptors in vasculature and kidneys; (b) reduce the expression and activity of angiotensin-converting enzyme, and (c) cause the release of angiotensinogen substrate from the liver. However, the degree of activation or suppression of the renin-angiotensin-aldosterone system by estrogen has not been clearly established. Clinical data on the effects of estrogen therapy on bone mineral densities are extremely limited in the ESRD population. CVD is the most common cause of death in postmenopausal women with CKD and many contributing factors have been explored. INTRODUCTIONMenopause is derived from the Greek words men (month) and pauses (cessation) and means permanent cessation of menstruation after the loss of ovarian activity. Clinically, menopause is defined as the absence of menstruation for 12 months. 1 In clinical medicine, it is well known that menopause is associated with accelerated progression of vascular diseases and osteoporosis as a long-term health risk in women. Indeed, menopausal status increases the risk of cardiovascular disease (CVD) by more than three-fold in women with normal kidney function. 2 Several factors such as the prevalence of hypertension, 3 diabetes, 4 dyslipidemia 5 and so on are known contributors to CVD. In addition to these factors, several studies reveal that chronic kidney disease (CKD) is closely related with CVD events. 6-9 Moreover, Perticone et al. 10 have recently demonstrated that the reduction of estimated glomerular filtration rate (GFR) was associated with the increased risk of death and CVD events, independently of traditional CV risk factors, menopause duration and presence of metabolic syndrome.In addition to these risks in CVD, women lose an average of 25 percent of their bone mass from the time of menopause to age 60, due in large part to the loss of estrogen. Over time, this loss of bone mass can lead to osteoporosis and its related fractures are a serious problem affecting postmenopausal women. 11 Recently, two serious sequels of menopause have been closely associated with CKD. CKD is associated with accelerated progression of CVD, per...

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Multifactorial Determination of Hypertensive Nephroangiosclerosis

Cited by 18 publications

References 177 publications

Short- and long-term prognosis of blood pressure and kidney disease in women with a past history of preeclampsia

Short- and long-term prognosis of blood pressure and kidney disease in women with a past history of preeclampsia

Multifactoral analysis of determinators for renal injury in essential hypertension

Chronic kidney disease in postmenopausal women

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