Multifocal Involvement of the Pancreas in Multiple Myeloma: Sonographic,  CT, and MR Imaging Findings

Balliu, E.; Casas, Josefina; Barluenga, Eva; Guasch, Ignasi

doi:10.2214/ajr.180.2.1800545

Cited by 24 publications

(22 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is most often located in the head of the pancreas (8). The CT appearance of pancreatic plasmacytoma is well established and typically described as a multilobular, hypodense solid tumor (9). Other possible diagnostic modalities such as endoscopic US, magnetic resonance imaging, and PET can also detect the pancreatic mass.…”

Section: Discussionmentioning

confidence: 99%

Biliary Obstruction Secondary to an Extramedullary Plasmacytoma of the Pancreas

Coskun¹,

Kaynar²,

Yagbasan³

2015

Erciyes Med J

View full text Add to dashboard Cite

Extramedullary plasmacytoma (EMP) is an uncommon neoplastic disorder arising from B-cell lymphocytes and comprises 3% of the plasma cell neoplasms. Ninety percent of the cases are encountered in the head and neck regions. The involvement of the pancreas is rare and generally develops as secondary multiple myeloma (MM). To date, four cases of EMP of the pancreas, which developed as secondary solitary bone plasmacytoma, have been reported in the literature. We decided to present this rare case, which was diagnosed and treated at our clinic.

show abstract

Section: Discussionmentioning

confidence: 99%

Biliary Obstruction Secondary to an Extramedullary Plasmacytoma of the Pancreas

Coskun¹,

Kaynar²,

Yagbasan³

2015

Erciyes Med J

View full text Add to dashboard Cite

show abstract

“…Most are single lesions; in some cases, two or more concurrent lesions may occur, and even more rarely, the lesion has its epicentre in another abdominal organ but is large enough to affect the pancreas too, mainly the pancreatic tail [32,41,42] (Fig. 1a, b).…”

Section: Location Of the Pancreatic Lesionsmentioning

confidence: 99%

“…Therefore, TUS can help detect only 60-70% of pancreatic masses, and similar to CT scanning, more than 40% of the lesions smaller than 3 cm are missed. On TUS, pancreatic infiltration by EMP has been described as a heterogeneous focal mass most often located in the head of the pancreas that is hypoechoic relative to the normal parenchyma and shows fine internal echoes [21,42].…”

Section: Transcutaneous Ultrasonographymentioning

confidence: 99%

“…The CT appearance of pancreatic EMP is well established and is typically described as a multilobular homogenous solid tumour that is hypodense as compared to the pancreatic parenchyma. Diffuse enlargement of the pancreatic gland has been cited in only a few cases, and the contrast enhancement has been described as homogeneous or heterogeneous However, these CT features are not specific since they resemble typical findings in other pancreatic neoplasms, including carcinoma, islet cell tumours, lymphoma and metastases [15,21,24,27,42,46,[59][60][61][62][63].…”

Section: Computed Tomography Scanmentioning

confidence: 99%

“…On fatsuppressed T1-weighted MR images, the signal intensity of the pancreas is less than that of the liver, whereas on T2-weighted images, it is higher. Pancreatic contrast enhancement is heterogeneous, but dynamic MR imaging was never performed [38,42,64].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

See 2 more Smart Citations

Pancreatic Involvement by Plasma Cell Neoplasms

Silva

2011

J Gastrointest Canc

View full text Add to dashboard Cite

Introduction Pancreatic involvement by plasma cell neoplasms is an extremely rare event, with only 50 cases described in the literature. They can present as a primary solitary extramedullary plasmacytoma or plasmacytoma secondary to a plasma cell myeloma. Clinical manifestations are due to the presence of a pancreatic mass usually in the pancreas head, which causes extra-biliary obstruction and abdominal pain. Methods Abdominal imaging including CT scan or endoscopic ultrasound with fine-needle aspiration tissue sampling is essential for the initial diagnostic procedure. However, immunohistochemical analysis of the biopsy specimen or flow cytometry of the aspirated material is crucial to prove the monoclonality and the final diagnosis of a plasma cell neoplasm. Discussion Management of these situations include radiotherapy, chemotherapy, surgery or combined therapy. Novel medications including the immunomodulatory drugs or the proteasome inhibitors followed by consolidation with intensive chemotherapy and haematopoietic stem cell transplantation are nowadays used as upfront treatment in the cases associated to a plasma cell myeloma. Conclusion Despite the rarity, plasma cell neoplasms should be considered in the differential diagnosis of obstructive jaundice and pancreatic neoplasms since they are potentially treatable situations.

show abstract

Imaging features of the less common pancreatic masses

et al. 2012

View full text Add to dashboard Cite

Contrast-enhanced multiphase CT and dynamic gadolinium-enhanced MR have been validated in the literature as outstanding modalities for the evaluation of pancreatic pathology. In addition to the more frequently seen pancreatic adenocarcinoma, neuroendocrine tumors of the pancreas and cystic lesions such as serous and mucinous cystadenomas and IPMNs, a variety of benign and malignant lesions may occur in the pancreas. The purpose of this pictorial essay is to review the imaging findings of a variety of uncommon, benign and malignant, pancreatic neoplasms.

show abstract

Multifocal Involvement of the Pancreas in Multiple Myeloma: Sonographic, CT, and MR Imaging Findings

Cited by 24 publications

References 4 publications

Biliary Obstruction Secondary to an Extramedullary Plasmacytoma of the Pancreas

Biliary Obstruction Secondary to an Extramedullary Plasmacytoma of the Pancreas

Pancreatic Involvement by Plasma Cell Neoplasms

Imaging features of the less common pancreatic masses

Contact Info

Product

Resources

About