Multifocal retinal dysplasia in the rottweiler

Bedford, PG

doi:10.1136/vr.111.13.304

Cited by 9 publications

(12 citation statements)

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“…However, focal retinal dysplasia and folds have been described in Miniature Schnauzers 2,32 . Generalized retinal dysplasia in Miniature Schnauzers in our study population is congenital, inherited, and has clinical manifestations similar to this disorder in other breeds of dogs 32–39 . However, it is unique in that the retinal dysplasia was extensive, many affected puppies were blind secondary to retinal detachment, and it was associated with a mild unilateral or bilateral PHPV.…”

Section: Discussionmentioning

confidence: 52%

“…Idiopathic or inherited multiple congenital ocular anomalies have been reported with retinal dysplasia. These include microphthalmia, cataracts, microphakia, persistent hyaloid remnants, PHPV, persistent tunica vasculosa lentis, and retinal detachment in many breeds of dogs 24–40 . Inherited congenital retinal dysplasia and skeletal anomalies have been reported in Labrador Retrievers and Samoyeds 9,13,16,17 …”

Section: Introductionmentioning

confidence: 99%

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Inherited retinal dysplasia and persistent hyperplastic primary vitreous in Miniature Schnauzer dogs

Grahn

Storey

McMillan

2004

Veterinary Ophthalmology

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The objectives of this study were to define the clinical syndrome of retinal dysplasia and persistent primary vitreous in Miniature Schnauzer dogs and determine the etiology. We examined 106 Miniature Schnauzers using a biomicroscope and indirect ophthalmoscope. The anterior and posterior segments of affected dogs were photographed. Four enucleated eyes were examined using routine light microscopy and scanning electron microscopy. A pedigree was constructed and related dogs were test-bred to define the mode of inheritance of this syndrome. Congenital retinal dysplasia was confirmed in 24 of 106 related Miniature Schnauzer dogs. Physical and postmortem examinations revealed that congenital abnormalities were limited to the eyes. Biomicroscopic, indirect ophthalmoscopic, and neuro-ophthalmic examinations confirmed that some of these dogs were blind secondary to bilateral retinal dysplasia and detachment (nonattachment) (n = 13), and the remainder had generalized retinal dysplasia (n = 11). Fifteen of these dogs were also diagnosed with unilateral (n = 9) or bilateral (n = 6) persistent hyperplastic primary vitreous. Nutritional, infectious, or toxic etiologies were not evident on physical, postmortem, light microscopic, or transmitting and scanning electron microscopic examination of four affected Miniature Schnauzers. We examined the pedigree and determined that an autosomal recessive mode of inheritance was most likely. Three test-bred litters including those from affected parents, carrier and affected parents, and carrier parents confirmed this mode of inheritance. This study confirms that retinal dysplasia and persistent hyperplastic primary vitreous is a congenital abnormality that is inherited as an autosomal recessive condition in Miniature Schnauzers.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Inherited retinal dysplasia and persistent hyperplastic primary vitreous in Miniature Schnauzer dogs

Grahn

Storey

McMillan

2004

Veterinary Ophthalmology

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“…Retinal dysplasia has been described as an inherited condition in several breeds of dog . In this paper, we report the establishment of a breeding colony to study RD identified in American pit bull terriers, a breed in which the condition has not previously been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal dysplasia has been described as an inherited condition in several breeds of dog. 7,8,12,13,15,17,19,23,26,[35][36][37][38] In this paper, we report the establishment of a breeding colony to study RD identified in American pit bull terriers, a breed in which the condition has not previously been reported. As part of our initial investigations, we sought to rule out environmental causes of RD.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting lesions range in severity from multifocal RD, where histologically there is folding of retinal layers or duplication of one or more retinal neuronal layers, to more severe lesions including larger geographic regions of retinal malformation or even retinal detachment or nonattachment . RD has been reported as an inherited trait in several breeds of dog but may also result from environmental insults during retinal development including infection (e.g., canine herpesvirus), toxicity (e.g., vitamin A deficiency), and intra‐uterine irradiation . In most instances, lesions are present and detectable on examination of puppies at a few weeks of age, although one survey of dogs bred as leader dogs reported that lesions could develop or become apparent after the age at which the retina is mature …”

Section: Introductionmentioning

confidence: 99%

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