Multifocal Retinopathy in Borna Disease Virus Infected Rabbits

Krey, H.; Ludwig, Hanns; Boschek, C. B.

doi:10.1016/0002-9394(79)90135-1

Cited by 41 publications

(22 citation statements)

References 13 publications

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“…These were more severe in the 2-month-old than in the 1-month-old group. Some of the severely diseased animals appeared to be blind, as was reported for rabbits (Krey et al, 1979) and approx. 20 ~ of the rats of each group died from encephalitis.…”

Section: Response Of Different Age Groups To Rat-passaged Virussupporting

confidence: 59%

“…After adaptation of wild-type virus to the rabbit, this animal was regarded as the most sensitive and suitable model for studying clinical and immunopathological aspects of the disease Krey et al, 1979Krey et al, , 198 l, 1982G ierend & Ludwig, 198 l). In the search for a small-animal model, the mouse generally resisted infection, whereas the rat was susceptible (Nicolau & Galloway, 1928;Zwick, 1939).…”

Section: Introductionmentioning

confidence: 99%

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Persistent, Tolerant or Subacute Infection in Borna Disease Virus-infected Rats

Hirano

Kao

Ludwig

1983

Journal of General Virology

134

102

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SUMMARYThe rabbit-adapted Borna disease~(BD) virus strain V was passaged by intracerebral infection of 1-day-old Wistar rats. Infectivity titres reached l08 infectious units per gram of brain 4 weeks after infection. No clinical signs were evident. The persistent infection could be induced with adapted or field strains of BD virus. Strains were identified by neutralization tests. The virulence of the rabbit-adapted BD virus for the rat increased with rat passages. The 5th passage induced clinical symptoms in animals infected at 1 week of age or older. Between 20% and 50% of diseased rats died. Virusspecific antigen was detectable immunohistologically in neurons of rats infected at all ages. Animals inoculated at 1 or 2 months of age, but not the neonatal rats, showed signs of inflammation in the brain. Infected rats produced specific antibodies. In the older groups (infected at ages of 1 or 2 months), and especially in surviving animals, occasionally, neutralizing antibodies with high titres were found. Transfer of primed spleen cells resulted in subacute disease. These findings demonstrate that neonatal rats can acquire a persistent, tolerant infection and that expression of disease is mediated by immunological factors.

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Section: Response Of Different Age Groups To Rat-passaged Virussupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Persistent, Tolerant or Subacute Infection in Borna Disease Virus-infected Rats

Hirano

Kao

Ludwig

1983

Journal of General Virology

134

102

View full text Add to dashboard Cite

show abstract

“…During our studies on the pathogenesis of BD in rabbits [7], we observed a character istic multifocal retinochoroiditis. Outstand ing features were isolated inflammatory foci preferentially located in the posterior pole of the fundus.…”

Section: Discussionmentioning

confidence: 81%

“…In a recent study of experimental Borna disease (BD) in rabbits [7], we found a highly reproducible multifocal retiochoroidopathy preferentially located in the posterior pole. From preliminary studies with this neuro tropic virus [8] in a limited number of rhesus monkeys [9], we concluded that these exper iments could serve as an appropriate model for infectious retinochoroidal diseases.…”

Section: Introductionmentioning

confidence: 83%