Multifocal skeletal tuberculosis with Rhodotorula minuta co-infection

Thanos, Loukas; Mylona, S.; Kokkinaki, Anna; Pomoni, Maria; Tsiouris, Spyridon; Batakis, Nikos A.

doi:10.1080/00365540500372648

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…No additional studies were found by hand‐screening of the included articles’ references. Finally, 111 met the criteria . Additional information was kindly provided by the corresponding author of one study .…”

Section: Resultsmentioning

confidence: 99%

Rhodotorula species infections in humans: A systematic review

Ιωάννου

Vamvoukaki

Samonis

2018

Mycoses

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| INTRODUC TI ONRhodotorula belongs to the phylum Basidiomycota and forms spherical-to-ellipsoidal budding yeast as well as rudimentary hyphae and small capsules. 1 It is widely distributed in the environment and is also found in the normal flora of the human gastrointestinal, respiratory and genital system as well as in the moist areas of the skin. 2 Even though it had been considered nonpathogenic, in the last decades there is growing evidence that it can be important human pathogen, especially in immunocompromised hosts, causing a variety of different infections, such as fungaemia, meningitis, peritoneal dialysis-associated peritonitis and keratitis. 3,4 The purpose of this study was to systemically review all published cases of Rhodotorula infections in the literature and describe the epidemiology, microbiology, treatment and outcomes of these infections in humans. SummaryBackground: Fungal infections by Rhodotorula species are increasingly reported in the literature and consist of bloodstream infections, especially in patients with central venous catheters (CVC), as well as central nervous system (CNS), ocular and other less frequent infections. Objectives: The aim of this systematic review was to record and evaluate all available evidence regarding infections by Rhodotorula species. Methods: Systematic review of PubMed (through 9 August 2017) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Rhodotorula species infections.Results: A total of 111 studies, containing data of 248 patients, were eventually included in the analysis. The most common Rhodotorula infections were those of bloodstream, CNS and ocular infections, as well as peritoneal dialysis-associated peritonitis.Epidemiology of each type of infection was different, with the bloodstream ones being more common in patients with malignancy and CVCs, while those of the CNS were more common in patients with AIDS. Mortality was variable being higher in CNS infections. Amphotericin B remains the most common agent used for treatment, irrespectively of the infection site. Conclusions: This systematic review thoroughly describes fungal infections byRhodotorula species and provides information on their epidemiology, clinical picture, microbiology, treatment and outcomes. K E Y W O R D S fungaemia, fungal infection, keratitis, meningitis, peritonitis, Rhodotorula | 91 IOANNOU et Al. with the following text-word: Rhodot*[tw]. Day of last search was 9 August 2017. | Study selectionStudies were included in analysis if they met the following criteria: (a) published in English; and (b) reporting data on patients' clinical characteristics, microbiology, treatment and outcomes. From the analysis were excluded studies with the following criteria: (a) secondary research papers (eg, reviews), editorials and papers not reporting results on primary research; (b) studies not in humans; (c) studies on colonisation but not infection by Rhodotorula; and (d) studies not in English. Two investigators (PI and RV) using Ab...

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Section: Resultsmentioning

confidence: 99%

Rhodotorula species infections in humans: A systematic review

Ιωάννου

Vamvoukaki

Samonis

2018

Mycoses

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“…Despite their low ratio, R. minuta account for the causative agents for invasive Rhodotorula diseases, the number of published cases due to R. minuta began increasing after 1991. So far, nine cases have been definitely documented . A total of two cases of hip joint infection, two cases of fungaemia, three cases of endophthalmitis, one case of peritonitis and one case of sepsis have been described.…”

Section: Discussionmentioning

confidence: 99%

Rhodotorula minuta as onychomycosis agent in a Chinese patient: first report and literature review

Zhou

Chen

et al. 2013

Mycoses

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Onychomycosis is a common superficial fungal infection, which usually caused by dermatophytes, yeast and non-dermatophytic moulds. Recently, we isolated a Rhodotorula minuta isolate from a 15-year-old immunocompetent girl student in Hangzhou (China) that was identified using microscopy, culture morphology, histological diagnosis, API 20C AUX Yeast Identification Kit and sequencing of the Internal Transcribed Spacer region. In vitro, antifungal susceptibility tests showed that this yeast isolate was susceptible to low concentrations of amphotericin B, itraconazole, voriconazole and 5-flvoriconaz but that it appeared to be dose-dependent susceptible to fluconazole(MIC = 16 μg/ml). Furthermore, the effective result of therapy with itraconazole against R. minuta was consistent with that of susceptibility tests.

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“…These too are part of the normal skin microbiota but can cause a common superficial infection in tropical and subtropical regions known as "the white piedra" [47,146]. Four Rhodotorula mucilaginosa osteo-articular diseases were reported, one post-operative persistent femoral non-union [134], one femoral prosthesis infection [135], one hip-joint prosthesis infection [136], and one case of an infection associated with multifocal skeletal tuberculosis [137]. Saccharomyces cerevisiae was responsible for two cases of osteomyelitis [138,139] and Cryptococcus luteolus was responsible for a case of tenosynovitis [42].…”

Section: Skin Systemmentioning

confidence: 99%

A Repertoire of the Less Common Clinical Yeasts

Menu,

Filori,

Dufour

et al. 2023

JoF

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Invasive fungal diseases are a public health problem. They affect a constantly increasing number of at-risk patients, and their incidence has risen in recent years. These opportunistic infections are mainly due to Candida sp. but less common or rare yeast infections should not be underestimated. These so-called “less common” yeasts include Ascomycota of the genera Candida (excluding the five major Candida species), Magnusiomyces/Saprochaete, Malassezia, and Saccharomyces, and Basidiomycota of the genera Cryptococcus (excluding the Cryptococcus neoformans/gattii complex members), Rhodotorula, and Trichosporon. The aim of this review is to (i) inventory the less common yeasts isolated in humans, (ii) provide details regarding the specific anatomical locations where they have been detected and the clinical characteristics of the resulting infections, and (iii) provide an update on yeast taxonomy. Of the total of 239,890 fungal taxa and their associated synonyms sourced from the MycoBank and NCBI Taxonomy databases, we successfully identified 192 yeasts, including 127 Ascomycota and 65 Basidiomycota. This repertoire allows us to highlight rare yeasts and their tropism for certain anatomical sites and will provide an additional tool for diagnostic management.

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Multifocal skeletal tuberculosis with Rhodotorula minuta co-infection

Cited by 7 publications

References 14 publications

Rhodotorula species infections in humans: A systematic review

Rhodotorula species infections in humans: A systematic review

Rhodotorula minuta as onychomycosis agent in a Chinese patient: first report and literature review

A Repertoire of the Less Common Clinical Yeasts

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