Multifocal synchronous osteosarcoma

Taccone, A; Stadio, M. Di; Oliveri, M; Oddone, M.; Occhi, M

doi:10.1016/0720-048x(95)00624-y

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,2,5 In the other series, only patients who were treated recently survived after bone metastases (3 of 12 patients [Goorin et al 21 ]; 3 of 7 patients [Ferguson et al 22 ]). Similarly, 3 of our 11 patients with bone metastases alone remained alive at the time of this report: Two of them had resectable bone metas- 25 This disease has never been cured; and, to date, all affected patients have died. 26 None of our eight patients with more than two metastatic skeletal sites (without lung metastases) have survived.…”

Section: Discussionmentioning

confidence: 96%

Metastatic osteosarcoma at diagnosis

Mialou

Philip

Kalifa

et al. 2005

Cancer

239

View full text Add to dashboard Cite

Blends of polypropylene (PP) and thermoplastic elastomers (TPE), namely SBS (styrene‐butadiene‐styrene) and SEBS (styrene‐ethylene/1‐butene‐styrene) block copolymers, were prepared to evaluate the effectiveness of the TPE type as an impact modifier for PP and influence of the concentration of elastomer on the polymer properties. Polypropylene homopolymer (PP‐H) and ethylene–propylene random copolymer (PP‐R) were evaluated as the PP matrix. Results showed that TPEs had a nucleating effect that caused the PP crystallization temperature to increase, with SBS being more effective than SEBS. Microstructure characterization tests showed that in most cases PP/SEBS blends showed the smallest rubber droplets regardless of the matrix used. It was seen that SEBS is a more effective toughening agent for PP than SBS. At 0°C the Izod impact strength of the PP‐H/SEBS 30% b/w blend was twofold higher than the SBS strength, with the PP‐R/SEBS 30% b/w blend showing no break. A similar behavior on tensile properties and flexural modulus were observed in both PP/TPE blends. Yield stress and tensile strength decreased and elongation at break increased by expanding the dispersed elastomeric phase in the PP matrix. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 254–263, 2005

show abstract

Section: Discussionmentioning

confidence: 96%

Metastatic osteosarcoma at diagnosis

Mialou

Philip

Kalifa

et al. 2005

Cancer

239

View full text Add to dashboard Cite

show abstract

“…Synchronous type principally involves long bones in symmetric distribution, 15 while the metachronous group prefers the axial skeleton, such as pelvis, spine, shoulder girdle, skull, synchronous type usually occurs in typical osteosarcoma location, such as distal femur, proximal tibia, or humerus. 16 In the presented case, the main tumor was precisely located in the usual synchronous type location, however, multiple skip lesions could also be seen in the pelvic bone.…”

Section: Discussionmentioning

confidence: 99%

Advance MR evaluation of synchronous multifocal osteosarcoma with pathologic fracture

Setiawati

Lay

Testini³

et al. 2021

BJR|case reports

View full text Add to dashboard Cite

Objective: Synchronous multifocal osteosarcoma is a rare condition in which the osteosarcoma presents with multiple bone lesions at the time of diagnosis, usually without any visceral metastases. The first case was described in early 1930s by Silverman. To report a case of synchronous multifocal osteosarcoma in adolescent with pathologic fracture. Methods: An 18-year-old girl presented with a painful mass in the right thigh of 4 months’ duration and a history of thigh bone fracture a month ago. Patient’s medical records and family history was unremarkable. Physical examination showed angulation and shortening at right femoral region with tenderness and swelling. Initial radiograph and magnetic resonance (MR) images showed multiple lesions in right femoral shaft and pelvic bone with primary tumor in right distal femur with pathologic fracture and multiple bone marrow lesions found in the contralateral bones. Imaging and histopathologic results supported the diagnosis of synchronous multifocal osteosarcoma. After following the chemotherapy as the treatment of choice, the radiograph and MRI evaluation were done and showed reduction of the mass size with union of the destructed part with the formation of callus. The advance MRI revealed reduction of the overall mass and the composition of the viable area compared to previous study. The patient had satisfying response to chemotherapy series and a better functional outcome on subsequent visits. Results: Diagnosis of synchronous multifocal osteosarcoma was based on patient and family history and finding of multiple lesions in the MR images, meanwhile the plain radiograph only revealed the primary tumor. Amstutz described multifocal osteosarcoma as presence of one primary tumor and several smaller lesions. Most recent reviews concluded that multifocal osteosarcoma is bone-to-bone metastatic process rather than multicentric origin. The limitation in this case was absence of thoracic CT which is suggested to rule out any pulmonary metastases instead of routine chest radiograph. Conclusions: Although satisfying improvement was clinically achieved, further advanced MRI would be indicated to evaluate the progression of tumor and its respond to therapy.

show abstract

Multicentric osteosarcoma with long-term survival

et al. 2004

View full text Add to dashboard Cite

We present a 14-year-old girl with multicentric osteosarcoma who has survived for over 9 years to date. The patient first noticed right knee pain in 1992. Radiographs showed a destructive and sclerotic lesion of the right distal femur. Similar small sclerotic lesions were seen in the proximal metaphysis of the right femur, proximal site of the right humerus, and mid-posterior of the left humerus. A diagnosis of multicentric osteosarcoma was made on a biopsy of the right distal femur. The sclerotic lesions of the bilateral humeri disappeared after systemic chemotherapy (T-20), and thus wide excisions of the right distal femur and proximal femur were performed in 1993. New lesions appeared in the left iliac bone and the first lumbar vertebra on bone scintigraphy 24 months after the first surgery. Chemotherapy and wide excisions of the left iliac bone and the first lumbar vertebra were performed. The patient was well at the latest follow-up in April 2003, with no evidence of local recurrence or distant metastasis, but recently renal dysfunction appeared.

show abstract

Multifocal synchronous osteosarcoma

Cited by 6 publications

References 5 publications

Metastatic osteosarcoma at diagnosis

Metastatic osteosarcoma at diagnosis

Advance MR evaluation of synchronous multifocal osteosarcoma with pathologic fracture

Multicentric osteosarcoma with long-term survival

Contact Info

Product

Resources

About