This study aims to assess the capabilities of a weather forecasting system based on simulations performed with the COSMO (COnsortium for Small-scale Modeling) model over a domain located in southern Italy, employing a spatial resolution of about 1 km, driven by ECMWF-IFS global data. The model is run daily at the Italian Aerospace Research Center (CIRA), and the evaluation was performed from January to May 2018 using a combination of observational data, specifically data provided by the CIRA meteorological station, wind profiler and ceilometer. Moreover, data provided by radio sounding located at Pratica di Mare and ground stations at two other locations were also used. A model configuration optimized through a tuning procedure over the domain considered was employed, while the evaluation was performed by comparing daily values of several variables and using standard monitoring indices. The results highlight that the model has good capability in reproducing daily values of temperature, while precipitation intensity is generally underestimated, even if rain patterns are well captured (alternating rainy and dry days). Good agreement is also reported for wind speed, especially at 100 and 500 m altitude. Regarding radio sounding data, the COSMO model configuration selected can reproduce the vertical profile of temperature and dew point, with the exception of inversion points. Evaluation against ceilometer data is achieved in terms of cloud height and planetary boundary layer height.