Multifunctional Anticancer Platform for Multimodal Imaging and Visible Light Driven Photodynamic/Photothermal Therapy

Abstract

As a potential photosensitizer for photodynamic therapy (PDT), pure titanium dioxide has the drawbacks of low tissue penetration and possible damage to skin due to the triggered UV light. To realize near-infrared (NIR) laser-induced multimodal imaging guided therapy, we constructed a multifunctional core–shell structure (TiO2@Y2Ti2O7@YOF:Yb,Tm) by a facile coprecipitation route, followed by an annealing process. Under a single NIR laser irradiation, the highly cytotoxic reactive oxygen species (ROS) required for PDT can be generated due to the energy transfer from YOF:Yb,Tm to the Y2Ti2O7 photocatalyst which is responsive to blue emission (visible light), and the thermal effect can be simultaneously produced due to the nonradiative transition and the recombination of electron–hole pairs. The NIR light induced PDT and photothermal therapy (PTT) can efficiently suppress tumor growth, which was evidenced by both in vitro and in vivo results. Moreover, the rare earth ions in the composite make the material have good up-conversion luminescence (UCL) imaging and CT imaging properties, thus achieving the target of synergistic PDT and PTT therapy under the multimodal imaging guidance.

Integration of IR‐808 Sensitized Upconversion Nanostructure and MoS2 Nanosheet for 808 nm NIR Light Triggered Phototherapy and Bioimaging

“…Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a promising method for cancer therapy due to its high therapeutic efficacy and low adverse effects . With various mechanisms, the combination of PTT and PDT will provide a highly efficient approach for cancer therapy . The addition of imaging functions to such a system could allow not only real‐time detecting of the profiles of tumor and its margins, but also observing the dynamic distribution of nanoparticles …”

Synthesis of a poly(ethylene glycol) galloyl sensitizer tip for an ’all‐in‐one' photodynamic device

“…Pointsource PDT offers simultaneous delivery of oxygen, light, and sensitizer to the tumor site, creating a highly‐localized killing zone. In view of the utility of PDT , an all‐in‐one PDT device could provide surgeons with a means to deliver precursors to 1 O 2 , placing all components necessary for PDT at the tumor site and nowhere else in the body. If successful, this device would add a new treatment concept.…”

Simultaneous morphology manipulation and upconversion luminescence enhancement of β-NaYF4:Yb3+/Er3+ microcrystals by simply tuning the KF dosage

“…As a significant class of rare earth compounds, rare earth (RE) fluorides have been become a research focus in the material field due to their unique applications in optical communications, three-dimensional displays, solid-state laser, photocatalysis, solar cells, biochemical probes and medical diagnostics910111213. Among them, NaYF 4 has been regarded as one of the most excellent host lattices for performing multicolor upconversion (UC) luminescence of the doped RE ions, due to its low phonon energy, high chemical stability and good optical transparency over a wide wavelength range14151617.…”