Multifunctional aptamer-conjugated magnetite graphene oxide/chlorin e6 nanocomposite for combined chemo-phototherapy

Işıklan, Nuran; Hussien, Nizamudin Awel; Türk, Mustafa

doi:10.1016/j.colsurfa.2022.128841

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…15−17 Recently, graphene and its derivative graphene oxide (GO) have been utilized as theranostic nanocarriers due to their high specific surface area. 18,19 Graphene and GO as two-dimensional single-layer sp 2 -bonded carbon atoms packed into a honeycomb lattice are indeed ideal platforms for highly efficient drug loading. This carbon allotrope has gained significant interest in life sciences due to its electronic, optical, and structural properties.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Usually, drug molecules are targeted to desired specific cells or organs via passive (size, property, etc.) or active (particular targeting ligands) targeting, in which passive targeting strategies are known as less efficient. , The active targeting strategy involving carbohydrates is controllable and efficient and benefits from the carbohydrates’ well-defined chemical structure, biocompatibility, biodegradability, and water solubility for nanomedicine. − Recently, graphene and its derivative graphene oxide (GO) have been utilized as theranostic nanocarriers due to their high specific surface area. , Graphene and GO as two-dimensional single-layer sp 2 -bonded carbon atoms packed into a honeycomb lattice are indeed ideal platforms for highly efficient drug loading. This carbon allotrope has gained significant interest in life sciences due to its electronic, optical, and structural properties. − In particular, GO with abundant functional groups of carboxylic acid, hydroxide, and epoxides can be loaded with various drugs by the non-covalent method via π–π stacking, hydrophobic/electrostatic interactions, and hydrogen bonding .…”

Section: Introductionmentioning

confidence: 99%

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NI-BODIPY-GO Nanocomposites for Targeted PDT

et al. 2023

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Three multifunctional targeted NI-BODIPYs (10–12) and GO-(10–12) nanocarriers were fabricated. NI-BODIPYs are designed to facilitate non-covalent interaction with graphene oxide (GO) and target toward cancer cells for specific recognition with glucose moieties while efficiently producing singlet oxygen. We probed detailed characterization, fundamental photophysical/photochemical properties, and interactions with GO of such triplet photosensitizers and nanocarriers. The effect of the formation of nanohybrids with GO on singlet oxygen formation as well as on the efficacies of the molecules in terms of in vitro killing of cancer cells was evaluated with K562 human chronic myelogenous leukemia cells. Amazingly, it was observed that GO exhibited favorable interactions with the NI-BODIPY dyads and promoted the formation of singlet oxygen, while not showing any dark toxicity.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

NI-BODIPY-GO Nanocomposites for Targeted PDT

et al. 2023

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“…Nanocomposites based on graphene oxide and magnetite, containing chloring e6 photosensitizer and conjugated aptamers showed enhanced and selective cytotoxicity of MCF‐7 cells (176).…”

Section: Combination Of Pdt With Other Therapiesmentioning

confidence: 99%

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy^†

Mariño-Ocampo¹,

Dibona‐Villanueva

Álvarez

et al. 2022

Photochem & Photobiology

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Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which is currently used to treat cancerous lesions and tumors that have been in the spotlight for its potential over the recent decades. Nonetheless, PDT still needs further development to become a first-option treatment for patients. This review compiles recent progress in several aspects of the current research in the constantly growing area of PDT to overcome the main challenges as an attempt to serve as a guide and reference for newcomers into this research area. This review has been prepared to highlight the use of chemical modifications on photosensitizers to improve their solubility, photostability, selectivity and phototoxicity. Additionally, the use of liposomes and cavitands as drug delivery systems to aid in the biodistribution and bioaccumulation of photosensitizers is presented. Also, the combination of PDT with chemotherapy or immunotherapy as an option to boost and improve treatment outcomes is discussed. Finally, the inhibition of antioxidant enzymes as a strategy for a synergistic effect to ameliorate the performance of the photosensitizers in PDT is presented as an alternative for future researchers.

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“…Magnetic iron oxide nanoparticles have been applied to magnetic drug delivery systems by many researchers owing to their perfect preparation technology and good biocompatibility (Işıklan et al. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Deng

Yin

et al. 2022

Drug Delivery

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Magnetic Fe 3 O 4 nanoparticles were prepared via a simple hydrothermal method and utilized to load paclitaxel. The average particle size of Fe 3 O 4 nanoparticles was found to be 20.2 ± 3.0 nm, and the calculated saturation magnetization reached 129.38 emu/g, verifying superparamagnetism of nanomaterials. The specific surface area and pore volume were 84.756 m 2 /g and 0.265 cm 3 /g, respectively. Subsequently, Fe 3 O 4 @mSiO 2 nanoparticles were successfully fabricated using the Fe 3 O 4 nanoparticles as precursors with an average size of 27.81 nm. The relevant saturation magnetization, zeta potential, and specific surface area of Fe 3 O 4 @mSiO 2 -NH 2 -FA were respectively 76.3 emu/g, −14.1 mV, and 324.410 m 2 /g. The pore volume and average adsorption pore size were 0.369 cm 3 /g and 4.548 nm, respectively. Compared to free paclitaxel, the solubility and stability of nanoparticles loaded with paclitaxel were improved. The drug loading efficiency and drug load of the nanoformulation were 44.26 and 11.38%, respectively. The Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites were easy to construct with excellent active targeting performance, pH sensitivity, and sustained-release effect. The nanoformulation also showed good biocompatibility, where the cell viability remained at 73.8% when the concentration reached 1200 μg/mL. The nanoformulation induced cell death through apoptosis, as confirmed by AO/EB staining and flow cytometry. Western blotting results suggested that the nanoformulation could induce iron death by inhibiting Glutathione Peroxidase 4 (GPX4) activity or decreasing Ferritin Heavy Chain 1 (FTH1) expression. Subsequently, the expression of HIF-1α was upregulated owing to the accumulation of reactive oxygen species (ROS), thus affecting the expression of apoptosis-related proteins regulated by p53, inducing cell apoptosis.

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Multifunctional aptamer-conjugated magnetite graphene oxide/chlorin e6 nanocomposite for combined chemo-phototherapy

Cited by 9 publications

References 43 publications

NI-BODIPY-GO Nanocomposites for Targeted PDT

NI-BODIPY-GO Nanocomposites for Targeted PDT

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy^†

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

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Multifunctional aptamer-conjugated magnetite graphene oxide/chlorin e6 nanocomposite for combined chemo-phototherapy

Cited by 9 publications

References 43 publications

NI-BODIPY-GO Nanocomposites for Targeted PDT

NI-BODIPY-GO Nanocomposites for Targeted PDT

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†

Effect and mechanism of paclitaxel loaded on magnetic Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites to MCF-7 cells

Contact Info

Product

Resources

About

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy^†

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells