Multifunctional Asymmetric Bacterial Cellulose Membrane with Enhanced Anti‐Bacterial and Anti‐Inflammatory Activities for Promoting Infected Wound Healing

Abstract

An asymmetric wound dressing acts as a skin‐like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver‐metal organic frameworks (Ag‐MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti‐bacterial activities. Compared to BC‐based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full‐thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC‐based dressing.

High-Density Dynamic Bonds Cross-Linked Hydrogel with Tissue Adhesion, Highly Efficient Self-Healing Behavior, and NIR Photothermal Antibacterial Ability as Dressing for Wound Repair

“…An infected wound typically exhibits high ROS levels and inflammation as the bacteria will activate the body’s immune response. , High ROS levels and inflammation will inhibit the activity of skin-repair-related cells, thereby delaying tissue regeneration. , In such cases, it is crucial for infected wound repair to reduce the high ROS levels and inflammation to normal levels.…”

Driven metal organic frameworks based hydrogels as wound dressing for anti‐inflammatory and antibacterial

“…In order to improve the solubility of ZIF and increase the drug loading, Yang and coworkers designed a liquid MOF-hydrogel (ZIF-91-PL composite hydrogel) based on ZIF-90 (the synthesis procedure of ZIF-91-PL and illustration MOF-hydrogel dressing for diabetic wound healing shown in Figure 5c,d). 38 Solubility of ZIF-91-PL was improved, and it could reach full load in a short time of contact with drugs. High drug loading and sustained release are more beneficial to long-term antibacterial, especially for diabetic wound healing.…”

“…This also accelerates the emergence of intelligent MOF-hydrogels with anti-inflammatory, antibacterial, and wound healing functions. [36][37][38] MOF is a complex polymer with three-dimensional pore structure composed of transition metal ions and organic ligands, and most of metal ions (e.g., Co 2+ , Zn 2+ , Ag + , and Cu 2+ ) have antibacterial activity. 39,40 Hydrogel has features of tensile, water retention, fluidity, biocompatibility, and biodegradability.…”

“…58 (c) Schematic diagram of the synthesis process of ZIF-91-PL and (d) illustration of MOFhydrogel dressing used to promote wound healing. 38 (e) Quantitative analysis of inhibitory effect of MOFhydrogel on proinflammatory factor expression. (n.s means no significance, **p < 0.01, ****p < 0.0001).…”

“…Furthermore, MOFs can function as a carrier for antibacterial and anti-inflammatory drugs, leading to a synergistic bactericidal effect when combined with such drugs. 19,20 Despite the potential benefits of MOFs, they still have certain limitations. One such limitation is the possibility of leakage or failure in carrying guest molecules because of a difference in size between the guest molecules and the pore size of MOFs, which ultimately reduces the effective load.…”