Multifunctional calcium polyphenol networks reverse the hostile microenvironment of trauma for preventing postoperative peritoneal adhesions

Abstract

Abdominal adhesions, a common complication of abdominal surgery, have a high incidence and adversely affect the physical and mental health of patients. The primary causes of abdominal adhesions are intraoperative...

Biosafe Polydopamine-Decorated MnO2 Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

“…The underlying mechanisms driving postoperative adhesion formation are complex. The inevitable tissue damage, bleeding, hypoxia, and the local inflammatory response following surgery are of prime importance in the development of pathologic adhesion. ,− Hypoxia can trigger a series of intracellular responses that involve hypoxia-inducible factors, lactate, reactive oxygen species (ROS), and reactive nitrogen species (RNS), and the increased ROS/RNS level and the suppression of the antioxidant system promote the adhesion formation via oxidative stress . Meanwhile, the imbalance between these systems not only induces a deteriorating inflammatory response but also hinders the regeneration of tissue .…”

Photoactive Poly-L-Lysine gel with resveratrol-magnesium metal polyphenol network: A promising strategy for preventing tracheal anastomotic complications following surgery

“…Clinically, the usual approach to address this challenge involves local steroid injections under bronchoscopy; however, this often fails to yield the expected results. Among the current anti-inflammatory agents, our previous research has found that polyphenolic compounds exhibit strong effects in suppressing inflammatory factors and promoting macrophage phenotype polarization [ [14] , [15] , [16] , [17] ]. Through screening potential candidate molecules, resveratrol emerged as the most promising agent for its anti-fibrotic properties and its ability to promote tissue repair.…”