Multifunctional DNA Nanogels for Aptamer‐Based Targeted Delivery and Stimuli‐Triggered Release of Cancer Therapeutics

Lee, Kyungsene; Kim, Tae-Hyung; Kim, Young Min; Yang, Kyungjik; Choi, In-Seok; Roh, Young Hoon

doi:10.1002/marc.202170003

Cited by 9 publications

(6 citation statements)

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“…Upon laser irradiation, the heat generated by AuNPs through the photothermal effect is transmitted to the ambient DNA molecules. When the temperature reaches the threshold, the chemical linkages break, thus leading to DNA release [42].…”

Section: Nucleic Acid Deliverymentioning

confidence: 99%

Nanogold: a versatile therapeutic agent in oncology

et al. 2022

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Nanogold is an emerging and versatile therapeutic agent since decades. Nanoogold and its’complexes can be synthesized through different ways. Its’ use in oncology as a drug delivery vehicle, phothothermal agent, Nucliec acid delivery vehicle and a photodynamic agent has been investigated by many researchers. Au nanoparticles (AuNPs) are nanovehicles with inimitable optical properties and incredible biocompatibility which have the property to effect the fate of cancer by delivering anticancer drugs, nucleic acids to cancer cells and tissues. Herein different modes of applications of nanogold in oncology and the challenges during the use of nanogold as therapeutic agent have been discussed. Nanogold and its’ complexes can be used as a biocompatible and efficient tool to treat and diagnose different types of cancer which are discussed with details in this review.

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Section: Nucleic Acid Deliverymentioning

confidence: 99%

Nanogold: a versatile therapeutic agent in oncology

et al. 2022

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“…Lee et al recently reported temperatureresponsive supramolecular DNA nanogels for combinational anticancer therapy (Figure 1F). 62 This platform was constructed using three types of functional DNA nanobuilding units: a multifunctional branched unit, a DNA−Au nanoparticle unit, and a linker unit. Each unit was self-assembled into nanogels ∼200 nm in size with precisely designated sticky ends (10−20 bp) for controlled thermal responsiveness (45− 60 °C), which is applicable at physiological temperatures.…”

Section: Recent Advances In Dna-assisted Smart Nanocarriersmentioning

confidence: 99%

DNA-Assisted Smart Nanocarriers: Progress, Challenges, and Opportunities

et al. 2021

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Due to powerful breakthroughs in nanotechnology, smart delivery mechanisms have rapidly emerged for use in diverse applications across biomedical research and therapeutic development. Recent efforts toward understanding stimuli-responsive strategies have led to substantial improvements in their conceptual application and in vitro efficiency. Because disease targets for therapy are often localized in specific cells, organs, or tissues, an enhanced permeability and retention (EPR)-based strategy remains inadequate for accurate drug delivery and release to target regions, resulting in an insufficient drug concentration reaching the target region and undesired side effects. To address these issues, more precise and remote-controlled stimuli-responsive systems, which recognize and react to changes in the pathophysiological microenvironment, were recently elucidated as feasible on-demand drug-delivery systems. In this Perspective, we focus on progress toward stimuli-responsive drug-delivery systems that utilize dynamic DNA molecules by exploiting DNA nanotechnology. DNA structures can be precisely reconfigured by external and internal stimuli to drive the release of a loaded drug in a target region with appropriate microenvironments. We describe the chemical, physical, and biological engineering principles and strategies for constructing DNA-assisted nanocarriers. We also provide a summary of smart nanocarrier systems, organized with respect to the structural changes in the DNA strand in the microenvironment, resulting from changes in pH and temperature and the presence of intracellular oligonucleotides. To do so, we highlight recent advances in related biomedical research and applications as well as discuss major challenges and opportunities for DNA-assisted nanocarriers to guide the development of future in vivo therapies and clinical translation strategies.

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“…The above‐mentioned characteristics of DNA nanogels make it potential ideal delivery vehicle for various cancer treatments, including chemotherapy, gene therapy, and immunotherapy. In comparison to other DNA nanostructures, such as DNA origami, the construction method of DNA nanogel is relatively simple without complicated programming, [ 22 ] which improves the universality of this intelligent nanocarrier, and based on Watson–Crick base pairing principle of DNA bases, DNA strands are also used as cross‐linkers to drive other materials, such as polymer, [ 23 ] gold nanoparticles (AuNPs), [ 24 ] and protein, [ 25 ] to construct smart hybrid nanogels for drug delivery. [ 26 ] In this review, we focus on DNA nanogels based on pure DNA materials and these DNA nanogels are categorized into two types depending on their construction methods, that is, rolling circle amplification (RCA)‐based DNA nanogel [ 27 ] and hybridization‐based DNA nanogel.…”

Section: Introductionmentioning

confidence: 99%

DNA Nanogel for Cancer Therapy

Zhang

Yan

Song

et al. 2023

Advanced Therapeutics

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DNA nanogel exhibits properties of both the DNA and hydrogel, for example, remarkable biocompatibility, programmability, high drug loading capacity, and rapid stimuli‐responsive nature to microenvironment, which make it a potential ideal carrier for drug and gene delivery. In this review, DNA nanogels are categorized into two types, that is, rolling circle amplification‐based nanogel and hybridization‐based nanogel. Construction methods, design ideas for different functions, and applications in chemotherapy, gene therapy, and immunotherapy of nanogels are discussed. It is believed that this review will help readers to have a deeper understanding of the basic design strategies of DNA nanogels for specific targeting, loading of various anticancer agents, and stimuli‐responsive degradation of nanogels for the controlled release of drugs, which will ultimately help to design more effective delivery system for better therapeutic effects. It is very likely that DNA nanogel, as an intelligent drug carrier, will play a greater role in cancer treatment in future.

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Multifunctional DNA Nanogels for Aptamer‐Based Targeted Delivery and Stimuli‐Triggered Release of Cancer Therapeutics

Cited by 9 publications

References 0 publications

Nanogold: a versatile therapeutic agent in oncology

Nanogold: a versatile therapeutic agent in oncology

DNA-Assisted Smart Nanocarriers: Progress, Challenges, and Opportunities

DNA Nanogel for Cancer Therapy

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