Multifunctional ECM proteins in bone and teeth

Abstract

The extracellular matrix (ECM) of all tissues and organs is a highly organized and complex structure unique to the specific organ type. The ECM contains structural and functional proteins that define cellular function, organization, behavior and ultimately organ characteristics and function. The ECM was initially thought to contain only a specific set of secretory proteins. However, our group and several other groups have shown that the ECM contains functional proteins that have been previously defined as solely intracellular. In the present review, we have focused on the ECM of mineralized tissues namely: bone and dentin. We provide here, a brief review of some non-classical ECM proteins that have been shown to possess both intra and extracellular roles in the formation of these mineralized matrices.

Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration

“…We were particularly encouraged to note the increased expression of DPP and DMP1 along the interface of the soft tissue and dentin. DPP and DMP1 are key regulators of matrix mineralization and odontogenic differentiation [54]. Therefore, their expression at the interface of the pulp dentin complex is indicative of enhanced odontogenic differentiation and reparative dentin formation.…”

Retraction: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells

“…Therefore, odontoblasts are surrounded by collagen and dentin matrix proteins. A recent report has demonstrated that ECM, especially the dentin matrix protein component, contains functional proteins that have been previously defined as solely intracellular (19). However, DMP-1, which has a role in matrix mineralization, can act as both an intra-and extracellular-signaling molecule, thus impacting odontoblast differentiation (20,21).…”

Grp78 Is Critical for Amelogenin‐Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line

“…The key strategy for successful periodontal regeneration requires the stimulation of MSC-derived PDLSCs (Seo et al, 2004). In addition, recent studies have established that multifunctional ECM proteins regulate cell behavior (Rozario et al, 2010;Ravindran et al, 2014), and that modulated stem cell migration contributes to the initial process of tissue regeneration (Sonoyama et al, 2006). While the cellular responses to amelogenin, an ECM-biocompatible protein, in PDL fibroblasts have been examined Cheng et al, 2012), the key signaling molecules and effects on PDLSCs have yet be completely defined.…”