Multifunctional fluorescent iron quantum clusters for non-invasive radiofrequency ablationof cancer cells

Jose, Akhila; Surendran, Mrudula; Fazal, Sajid; Prasanth, B. Venkata; Menon, Deepthy

doi:10.1016/j.colsurfb.2018.02.058

Cited by 15 publications

(3 citation statements)

References 42 publications

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“…As the natural flora of the human gastrointestinal gut relates to various types of disease such as inflammatory bowel disease , type -I diabetes , mood disorders, hormonal disorders neurotransmitter modulation and cancers 24 As said in previous articles the oral microbiota to an extent influence on the oral squamous cell carcinoma.…”

Section: Gut Microbiota Disorders and Diseasesmentioning

confidence: 86%

A Current Review on Gut Microbiota For Healthy Life

2020

IJFMT

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The human gastrointestinal tract is highly populated by a vast and diverse community of different microbes. Every individual is provided with a unique gut microbiota which varies according to their food habits and dietary intakes. This human gastrointestinal tract gut microbiota has various functions by participating in host mechanisms or metabolisms acts as or gives protection against the pathogens invading microbes into the gut,and also play an important role in facilitating the immune system development and function. An slight alteration even in this natural flora of gut in the intestine can cause infectious disease and disorders to the human. Various infections due to antibiotics and gut bacterial communities,bacterial interactions,mood disorders,metabolic disorders,diabetes,allergic disease,inflammatory bowel disease,hormonal and many neurological processes can happen. Hence, it is very important in maintaining the natural flora of the gut as it maintains a healthy gut microbiota , structural integrity and protection. Recently ayurvedic medicines are used over allopathy for its less sides on the body and for maintaining a healthy gut microbiome. This review aims on the current status of the gut microbiota for healthy life under key problems identification and maintaining the current healthy gut microbiota in the human gastrointestinal tract.

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Section: Gut Microbiota Disorders and Diseasesmentioning

confidence: 86%

A Current Review on Gut Microbiota For Healthy Life

2020

IJFMT

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“…To further improve the efficacy of RF treatment and reduce the side effects on nearby tissues, multiple nanomaterials with high electrical conductivity including Au, [ 247 ] nickel (Ni), [ 248 ] iron, [ 249 ] silver (Ag), [ 250 ] QDs, [ 251 ] and single‐walled carbon nanotubes (SWNTs) [ 252 ] have been introduced to intensify the heat inside target tissue. Glazer et al.…”

Section: Pdac‐tailored Nanomaterials For Therapeutic Strategiesmentioning

confidence: 99%

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Xia

Lee

et al. 2021

Advanced Science

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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to its aggressiveness and the challenge to early diagnosis and treatment. In recent decades, nanomaterials have received increasing attention for diagnosis and therapy of PDAC. However, these designs are mainly focused on the macroscopic tumor therapeutic effect, while the crucial nano–bio interactions in the heterogeneous microenvironment of PDAC remain poorly understood. As a result, the majority of potent nanomedicines show limited performance in ameliorating PDAC in clinical translation. Therefore, exploiting the unique nature of the PDAC by detecting potential biomarkers together with a deep understanding of nano–bio interactions that occur in the tumor microenvironment is pivotal to the design of PDAC‐tailored effective nanomedicine. This review will introduce tailor‐made nanomaterials‐enabled laboratory tests and advanced noninvasive imaging technologies for early and accurate diagnosis of PDAC. Moreover, the fabrication of a myriad of tailor‐made nanomaterials for various PDAC therapeutic modalities will be reviewed. Furthermore, much preferred theranostic multifunctional nanomaterials for imaging‐guided therapies of PDAC will be elaborated. Lastly, the prospects of these nanomaterials in terms of clinical translation and potential breakthroughs will be briefly discussed.

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“…Thermal ablation of cancerous cells is achieved by using radiofrequency thermal treatment (RTT), which converts radiofrequency irradiation energy into heat using RF absorbing agents (Jose et al., 2018 ; Löffler et al., 2019 ; Rangamuwa et al., 2021 ). As a noninvasive, controlled, and highly effective therapeutic technique, RTT has attracted a lot of interest in recent years.…”

Section: Introductionmentioning

confidence: 99%

Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

Zhang

et al. 2022

Drug Delivery

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The field of biomedical research has recently been interested in nanoplatforms with various functionalities, such as cancer drug carriers and MRI and optical imaging, as well as thermal treatment, among other things. As a result of the present investigation, a unique multifunctional liposome (MFL) was established in this investigation. Using radiofrequency-induced imaging and drug release based on magnetic field impact, a dual drug delivery targeted with tumor multi-mechanism treatment was made more effective. The C60 (fullerene) surface was coated with iron nanocomposites to establish the proposed nanosystems, and PEGylation was used (Fe 3 O 4 -C60-PEG 2000 ). For fullerene radiofrequency-triggered drug release, thermosensitive DPPC liposomes with folate-DSPE-PEG 2000 enveloped the binary nanosystems and doxorubicin (DOX). The in vitro cytotoxicity of the nanocomposites was confirmed by the liver metastasis in HT-29 colon cancer cells using radiofrequency. The flow cytometry analysis confirmed the apoptosis cell death mechanism. The thermal treatment combined chemotherapeutic MFL nano framework transformed radiofrequency radiation from thermoresponsive liposomes, which was noticed both in vivo and in vitro . Due to their superior active tumor targeting and magnetic targeting characteristics, the MFL could also selectively destroy cancerous liver cells in highly co-localized targets.

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Multifunctional fluorescent iron quantum clusters for non-invasive radiofrequency ablationof cancer cells

Cited by 15 publications

References 42 publications

A Current Review on Gut Microbiota For Healthy Life

A Current Review on Gut Microbiota For Healthy Life

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

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