Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents

Abstract

Theranostic nanoparticles have attracted considerable attention in recently revolutionized medicine. Since the last decade, there has been a growing attempt to design various theranostic nanoparticles but difficulties still exist in the fabrication of their biocompatible one. Herein, fluorescent titania nanoparticles (FTN) were fabricated using a one-step green method. This FTN had ultra-high doxorubicin hydrochloride (DOX) loading capacity (encapsulation efficiency 95.50% and loading content 38.20%) that release the loaded drug in response to acidic pH. In vitro cytotoxicity experiments on human osteosarcoma (SaOs-2) and breast cancer (MCF-7) cell lines revealed superior anticancer efficacy (lowered the IC concentration by 3- and 5.5-fold for SaOs-2 and MCF-7 cells, respectively) and also better imaging for intracellular tracking of DOX/FTN relative to free DOX. Furthermore, the prepared nanoparticles showed efficient antibacterial activity against both gram-negative (Escherichia coli ATCC 25922) and gram-positive (Staphylococcus aureus ATCC 25923) bacteria. In this study, we have developed novel theranostic titania nanoparticles with inherent fluorescence property for cancer imaging and therapy.

Investigating the accumulation and translocation of titanium dioxide nanoparticles with different surface modifications in static and dynamic human placental transfer models

“…Moreover, concentrations up to 100 µg/mL could be realistic for a potential biomedical use of TiO 2 NPs (e.g. injected intravenously as drug carrier) [42,43].…”

Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells

“…The antimicrobial activity of different concentrations of ZnO-NPs (0–1250 μ g/mL) was evaluated against ATCC strains P. aeruginosa , E. coli , B. subtilis , S. aureus , A. baumannii , and C. albicans applying a broth microdilution plan according to the CLSI guidelines [ 36 ]. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured and reported as described previously [ 37 ].…”

Metal Oxide Nanoparticles as Biomedical Materials

“…In contrast to uncoated NPs that release the drug after 2 weeks, the modified nanooxide demonstrated extended-release up to 22 and 26 days for chitosan and PLGA, respectively. In 2018, Masoudi et al [90] prepared TiO 2 NPs with inherited fluorescence properties and high doxorubicin hydrochloride (DOX) loading capacity. In vitro cytotoxicity test on human osteosarcoma (SaOs-2) and breast cancer (MCF-7) cell lines revealed higher anticancer efficacy (lowered IC50 concentration by 5.5-and 3 fold for MCF-7 and SaOs-2, respectively) and better imaging for intercellular tracking of DOX loaded NPs relative to free DOX.…”