Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas

Shao, Chen; Li, Shuai; Gu, Wei; Gong, Ningqiang; Zhang, Juan; Chen, Ning; Shi, Xiangyang; Ye, Ling

doi:10.1021/acs.analchem.5b01639

Cited by 37 publications

(19 citation statements)

References 37 publications

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“…Although this r 1 value is not as high as the r 1 of Gd-doped CDs obtained in our previous work, 21 it is comparable to most Mn-based nanoparticles reported in the literatures. 23,26,30,31 It is known that the spin−lattice effect contributes to T 1 relaxation enhancement and a direct contact of the surface paramagnetic ions with the nearby water is thus necessary. Obviously, a shorter distance between the surface paramagnetic ions and the neighboring water protons is crucial for improved relaxivity.…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

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Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

Ai²,

Shao

et al. 2018

ACS Biomater. Sci. Eng.

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Brain gliomas are life-threatening diseases with low survival rates. Early detection and accurate intraoperative location of brain gliomas is vital to improving the prognosis. Herein, we synthesized manganese (Mn)-doped carbon dots (CDs) as magnetic resonance (MR)/optical dual-modal imaging nanoprobes by a one-pot green microwave-assisted route. These ultra-small-sized Mn-doped CDs possess distinct excitation-dependent photoluminescent emissions, high r 1 relaxivity, and low cytotoxicity. The in vivo MR imaging and ex vivo optical imaging of mouse brain with tiny glioma demonstrate that the Mn-doped CDs could lead to an enhanced MR T 1 contrast effect in the tiny brain glioma region, disclosing the great promise of these Mn-doped CDs as MR/optical dual-modal imaging nanoprobes for detection and intraoperative location of tiny brain gliomas.

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Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

“…Alternatively, manganese (Mn)-based nanoparticles has been used as an efficient MR nanoprobe. More importantly, Mn-based MR nanoprobes exhibit better performance in detection of brain diseases. − Nevertheless, the preparation of Mn-doped CDs as MR/optical dual-modal nanoprobe for brain glioma imaging remains unexplored so far.…”

Section: Introductionmentioning

confidence: 99%

Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

Ai²,

Shao

et al. 2018

ACS Biomater. Sci. Eng.

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“…To quantify the extent of the exchange reactions, we synthesized radiolabeled iron oxide nanoparticles via thermal decomposition with 14 C-oleic acid as a radiotracer. These particles were modified with citric acid, caffeic acid, zwitterionic dopamine sulfonate, dimercaptosuccinic acid (DMSA), (3-aminopropyl)triethoxysilane (APTES), 2-mercaptoethanol, ( N , N -bis(phosphono methyl) glycine), 2-aminoethyl phosphonic acid, 3-(2-pyridyl0-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt, and taurine.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Measurement of Ligand Exchange with Small-Molecule Ligands on Iron Oxide Nanoparticles via Radioanalytical Techniques

Davis¹,

Cole

Ghelardini³

et al. 2016

Langmuir

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Ligand exchange on the surface of hydrophobic iron oxide nanoparticles is a common method for controlling surface chemistry for a desired application. Furthermore, ligand exchange with small-molecule ligands may be necessary to obtain particles with a specific size or functionality. Understanding to what extent ligand exchange occurs and what factors affect it is important for the optimization of this critical procedure. However, quantifying the amount of exchange may be difficult because of the limitations of commonly used characterization techniques. Therefore, we utilized a radiotracer technique to track the exchange of a radiolabeled C-oleic acid ligand with hydrophilic small-molecule ligands on the surface of iron oxide nanoparticles. Iron oxide nanoparticles functionalized withC-oleic acid were modified with small-molecule ligands with terminal functional groups including catechols, phosphonates, sulfonates, thiols, carboxylic acids, and silanes. These moieties were selected because they represent the most commonly used ligands for this procedure. The effectiveness of these molecules was compared using both procedures widely found in the literature and using a standardized procedure. After ligand exchange, the nanoparticles were analyzed using liquid scintillation counting (LSC) and inductively coupled plasma-mass spectrometry. The labeled and unlabeled particles were further characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) to determine the particle size, hydrodynamic diameter, and zeta potential. The unlabeled particles were characterized via attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and vibrating sample magnetometry (VSM) to confirm the presence of the small molecules on the particles and verify the magnetic properties, respectively. Radioanalytical determination of C-oleic acid was used to calculate the total amount of oleic acid remaining on the surface of the particles after ligand exchange. The results revealed that the ligand-exchange reactions performed using widely cited procedures did not go to completion. Residual oleic acid remained on the particles after these reactions and the reactions using a standardized protocol. A comparison of the ligand-exchange procedures indicated that the binding moiety, multidenticity, reaction time, temperature, and presence of a catalyst impacted the extent of exchange. Quantification of the oleic acid remaining after ligand exchange revealed a binding hierarchy in which catechol-derived anchor groups displace the most oleic acid on the surface of the nanoparticles and the thiol group displaces the least amount of oleic acid. Thorough characterization of ligand exchange is required to develop nanoparticles suitable for their intended application.

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“…3 ). Gd-doped MnCO 3 NPs conjugated with both the near-infrared (NIR) dye Cy5.5 and FA (Gd/MnCO3-PEG-Cy5.5-FA NPs) [ 30 ] show higher targeting efficiency than non-targeted NPs in MR/fluorescence imaging of tiny GBMs. The advantages of using FA as a targeting agent for GBMs are that FA is water-soluble with little or no toxic effects [ 117 ], the molecular weight of FA is 441.4 Da.…”

Section: Modification Of Mri Contrast Agentsmentioning

confidence: 99%

Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics

Dai

Tang

et al. 2021

Regenerative Biomaterials

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Glioblastoma (GBM) is the most aggressive malignant brain tumour, with a median survival of 3 months without treatment and 15 months with treatment. Early GBM diagnosis can significantly improve patient survival due to early treatment and management procedures. Magnetic resonance imaging (MRI) using contrast agents is the preferred method for the preoperative detection of GBM tumours. However, commercially available clinical contrast agents do not accurately distinguish between GBM, surrounding normal tissue and other cancer types due to their limited ability to cross the blood–brain barrier, their low relaxivity and their potential toxicity. New GBM-specific contrast agents are urgently needed to overcome the limitations of current contrast agents. Recent advances in nanotechnology have produced alternative GBM-targeting contrast agents. The surfaces of nanoparticles (NPs) can be modified with multimodal contrast imaging agents and ligands that can specifically enhance the accumulation of NPs at GBM sites. Using advanced imaging technology, multimodal NP-based contrast agents have been used to obtain accurate GBM diagnoses in addition to an increased amount of clinical diagnostic information. NPs can also serve as drug delivery systems for GBM treatments. This review focuses on the research progress for GBM-targeting MRI contrast agents as well as MRI-guided GBM therapy.

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Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas

Cited by 37 publications

References 37 publications

Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

Quantitative Measurement of Ligand Exchange with Small-Molecule Ligands on Iron Oxide Nanoparticles via Radioanalytical Techniques

Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics

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