Multifunctional Hollow Mesoporous Silica Nanocages for Cancer Cell Detection and the Combined Chemotherapy and Photodynamic Therapy

Wang, Tingting; Zhang, Lingyu; Su, Zhong‐Min; Wang, Chungang; Liao, Yi; Fu, Qin

doi:10.1021/am200364e

Cited by 118 publications

(80 citation statements)

References 44 publications

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“…[ 204,205 ] The simplest structures are hollow mesoporous particles combining a large void space in the core and the mesoporous network in the shell (one compartment) - Figure 20 .…”

Section: Mesoporous Particlesmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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“…[ 204,205 ] The simplest structures are hollow mesoporous particles combining a large void space in the core and the mesoporous network in the shell (one compartment) - Figure 20 .…”

Section: Mesoporous Particlesmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…Mesoporous silica (MCM-41) nanoparticles are emerging as powerful nanotheranostic tools because of their porous structure, which allows them to host a large number of dye and drug molecules and because silica is considered to be safe and biodegradable. [19][20][21] While amorphous mesoporous silica nanoparticles show poor biocompatibility towards various cell types, [22][23][24] mobile composition matter of the MCM-41 type is well tolerated both in vitro and in vivo. 25 Polystyrene nanoparticles are also under evaluation for drug delivery and cellular imaging.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

Ekkapongpisit¹,

Giovia²,

Follo³

et al. 2012

IJN

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Background and methods Nanoparticles engineered to carry both a chemotherapeutic drug and a sensitive imaging probe are valid tools for early detection of cancer cells and to monitor the cytotoxic effects of anticancer treatment simultaneously. Here we report on the effect of size (10–30 nm versus 50 nm), type of material (mesoporous silica versus polystyrene), and surface charge functionalization (none, amine groups, or carboxyl groups) on biocompatibility, uptake, compartmentalization, and intracellular retention of fluorescently labeled nanoparticles in cultured human ovarian cancer cells. We also investigated the involvement of caveolae in the mechanism of uptake of nanoparticles. Results We found that mesoporous silica nanoparticles entered via caveolae-mediated endocytosis and reached the lysosomes; however, while the 50 nm nanoparticles permanently resided within these organelles, the 10 nm nanoparticles soon relocated in the cytoplasm. Naked 10 nm mesoporous silica nanoparticles showed the highest and 50 nm carboxyl-modified mesoporous silica nanoparticles the lowest uptake rates, respectively. Polystyrene nanoparticle uptake also occurred via a caveolae-independent pathway, and was negatively affected by serum. The 30 nm carboxyl-modified polystyrene nanoparticles did not localize in lysosomes and were not toxic, while the 50 nm amine-modified polystyrene nanoparticles accumulated within lysosomes and eventually caused cell death. Ovarian cancer cells expressing caveolin-1 were more likely to endocytose these nanoparticles. Conclusion These data highlight the importance of considering both the physicochemical characteristics (ie, material, size and surface charge on chemical groups) of nanoparticles and the biochemical composition of the cell membrane when choosing the most suitable nanotheranostics for targeting cancer cells.

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“…58 Silica-based nanoparticles, 26 gold nanoparticles, 27 quantum dots, 28 29 carbon-based nanomaterials, including carbon nanotubes, 30 fullerenes, 31 nano-diamonds, 32 graphene and grapheme oxides 33 34 are non-biodegradable nanostructures. Recently, mesoporous silica-based nanoparticles, 59-61 especially hollow, mesoporous silicabased nanoparticales, [62][63][64][65] have attracted much attention due to their excellent PDT performance when coupled with photosensitizers. 66 67 Because of the advantages of high surface areas, controllable pore and particle sizes and shapes, and versatile surface modifications, mesoporous silica-based nanoparticles provide a new platform for a range of applications, including improved cancer diagnoses, anticancer drug delivery, and targeted therapy.…”

Section: Strategies For Passive Targeted Delivery Of Nano-photosensitmentioning

confidence: 99%

“…66 67 Because of the advantages of high surface areas, controllable pore and particle sizes and shapes, and versatile surface modifications, mesoporous silica-based nanoparticles provide a new platform for a range of applications, including improved cancer diagnoses, anticancer drug delivery, and targeted therapy. [62][63][64][65] In particular, hollow mesoporous silica nanoparticles are more powerful and suitable than conventional mesoporous silica-based nanoparticles for treating cancer. They are especially preferred to act as drug delivery carriers because of their large internal cavities.…”

Section: Strategies For Passive Targeted Delivery Of Nano-photosensitmentioning

confidence: 99%

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

Lin¹,

Li²,

Wen³

et al. 2015

j biomed nanotechnol

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Cancer stem cells are believed to be the basis for tumor initiation, development, metastasis and recurrence; are resistant to most traditional therapies (e.g., chemotherapy and radiotherapy); and have the ability to self-renew, proliferate and differentiate. Photodynamic therapy may be a promising novel treatment for drug-resistant cancer stem cells because of the selectivity of the photosensitizer. One of the most important issues to overcome in photodynamic therapy is the photosensitizer-targeted delivery to tumor cells, especially cancer stem cells. Nano-photosensitizers comprising molecular photosensitizers and water-dispersible nanocarriers with or without moieties possessing the ability for specific binding to cancer cells or cancer stem cells are a promising strategy for active targeted photosensitizer delivery and photodynamic therapy-targeted therapy of tumors. In this review, we highlight current and future prospects for potential strategies based on nanoscience and nanotechnology for nano-photosensitizer-targeted delivery in the photodynamic therapy treatment of cancer cells, especially cancer stem cells.

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Multifunctional Hollow Mesoporous Silica Nanocages for Cancer Cell Detection and the Combined Chemotherapy and Photodynamic Therapy

Cited by 118 publications

References 44 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

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