Multifunctional hydrogel based on dopamine-modified hyaluronic acid, gelatin and silver nanoparticles for promoting abdominal wall defect repair

Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

“…It enhanced the antibacterial capabilities of the hydrogel via the addition of silver nanoparticles (Fig. 3 A) [ 105 ]. Furthermore, drugs may be incorporated into hydrogels by utilizing the swelling feature of hydrogels, simply by immersing them in drug-containing fluids.…”

Multifunctional conductive hyaluronic acid hydrogels for wound care and skin regeneration

“…Bioadhesiveness in HA hydrogels, which facilities the reconnection of skin tissue in a fast and efficient way, has been acquired by taking inspiration from mussels and, thus, introducing protein–catechol groups, either as PDA NPs 73 or by chemical modification of the HA backbone. 74,75 In fact, the tendency now is to prepare smart bioadhesive materials, in that they incorporate a biosensing function (in some cases wireless) that allows for real-time and precise evaluation of the healing stage. 76 Within this context, by using Li + and Na + as conductive ions, Lv et al designed mussel-inspired conductive HA hydrogels by employing borax as a dynamic cross-linking agent.…”

Facile Bond Exchanging Strategy for Engineering Wet Adhesion and Antioxidant/Antibacterial Thin Layer over a Dynamic Hydrogel via the Carbon Dots Derived from Tannic Acid/ε-Polylysine

“…The abundant water within hydrogels may impede intimate contact between the polymeric network and the adherend surface, weakening the adhesion performance. , Moreover, the swelling of hydrogel further reduces the interaction within the adhesive interface . Recently, inspired by marine organisms like mussel, barnacle, and sandcastle worm, great progress has been achieved in strong and universal wet adhesion. − Especially, mussel-inspired hydrogels present strong underwater adhesion via catechol chemistry, mainly including hydrogen bonding, hydrophobic forces, metal coordination, and π–π/cation–π interactions. − Various catechol or polyphenol species, such as dopamine, tannic acid (TA), and gallic acid (GA), and their derivatives have been decorated into a polymer network of hydrogels by different methods including bulk integration and surface modification strategies. − Meanwhile, biocidal moieties were usually loaded to meet the antibacterial needs in adhesive-bonded interfaces. − It is worth mentioning that the incorporation of some functional nanoparticles also imparts antioxidant properties to the hydrogel. − Notably, compared with the conventional methods of fabricating bulk adhesive hydrogels, , the generating strategies, such as anchoring thin adhesive polymeric coatings, assembling a soft armor-like hydrophobic surface, and natural sedimentation of adhesive nanoparticles, can endow the hydrogel surfaces with high-density adhesion moieties in a high catechol “atom economy” manner, while keeping the intrinsic physicochemical properties of the original hydrogel network intact . However, these methods used to functionalize the hydrogel surface with adhering properties commonly involve complicated fabrication procedures or uncontrolled operation.…”

“…21−23 It is worth mentioning that the incorporation of some functional nanoparticles also imparts antioxidant properties to the hydrogel. 24−26 Notably, compared with the conventional methods of fabricating bulk adhesive hydrogels, 6,27 the generating strategies, such as anchoring thin adhesive polymeric coatings, 28 assembling a soft armor-like hydrophobic surface, 29 and natural sedimentation of adhesive nanoparticles, 30 can endow the hydrogel surfaces with high-density adhesion moieties in a high catechol "atom economy" manner, while keeping the intrinsic physicochemical properties of the original hydrogel network intact. 31 However, these methods used to functionalize the hydrogel surface with adhering properties commonly involve complicated fabrication procedures or uncontrolled operation.…”

“…Adhesive hydrogels play an essential role in many emerging technologies such as stretchable electronics, soft robotics, flexible sensor, and tissue engineering. − However, it is a great challenge to realize universal adhesion of hydrogels to various substances, especially in a wet environment. The abundant water within hydrogels may impede intimate contact between the polymeric network and the adherend surface, weakening the adhesion performance. , Moreover, the swelling of hydrogel further reduces the interaction within the adhesive interface .…”