Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Zhang, Hui; Sun, Xinyu; Wang, Jiao; Zhang, Yalan; Dong, Mengna; Bu, Tong; Li, Lihua; Liu, Yingnan; Wang, Li

doi:10.1002/adfm.202100093

Cited by 216 publications

(136 citation statements)

References 56 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…Taken together, these results demonstrate that AgNP hydrogel promotes wound healing, which is consistent with a previous study using a planktonic bacteria wound model, which also showed an improved rate of wound closure in response to AgNP hydrogel treatment [ 59 ]. These results could be attributed to the combined effect of hydrogel biocompatibility and cell proliferative and antibacterial properties of ultra-small AgNPs to effectively eliminate bacterial pathogens and allow wound regeneration.…”

Section: Resultssupporting

confidence: 92%

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

et al. 2021

View full text Add to dashboard Cite

Biofilm-associated infections are a major cause of impaired wound healing. Despite the broad spectrum of anti-bacterial benefits provided by silver nanoparticles (AgNPs), these materials still cause controversy due to cytotoxicity and a lack of efficacy against mature biofilms. Herein, highly potent ultrasmall AgNPs were combined with a biocompatible hydrogel with integrated synergistic functionalities to facilitate elimination of clinically relevant mature biofilms in-vivo combined with improved wound healing capacity. The delivery platform showed a superior release mechanism, reflected by high biocompatibility, hemocompatibility, and extended antibacterial efficacy. In vivo studies using the S. aureus wound biofilm model showed that the AgNP hydrogel (200 µg/g) was highly effective in eliminating biofilm infection and promoting wound repair compared to the controls, including silver sulfadiazine (Ag SD). Treatment of infected wounds with the AgNP hydrogel resulted in faster wound closure (46% closure compared to 20% for Ag SD) and accelerated wound re-epithelization (60% for AgNP), as well as improved early collagen deposition. The AgNP hydrogel did not show any toxicity to tissue and/or organs. These findings suggest that the developed AgNP hydrogel has the potential to be a safe wound treatment capable of eliminating infection and providing a safe yet effective strategy for the treatment of infected wounds.

show abstract

Section: Resultssupporting

confidence: 92%

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Considering the successful application of enhancing antibacterial and antioxidant strategies in the development of new multifunctional hydrogel wound dressings, [7,10,46] the antibacterial and antioxidant performances of CS-based hydrogels were further evaluated. First, the antibacterial properties of pure CS hydrogels, CA-TA NEs hydrogels and CA-TA-ZA NSs hydrogels were evaluated.…”

Section: Resultsmentioning

confidence: 99%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

The goal of regenerative wound healing dressings is to restore tissue function back to normal physiological activity and accelerate skin tissue regeneration at wound sites. The optimal strategy to achieve this purpose requires a balance between material functionality, degradation, safety, and tissue regrowth. Herein, for the first time, an ultrasonic-triggered irreversible tending to equilibrium self-assembly and ionic cross-linking codriven strategy is proposed for producing multifunctional cinnamaldehyde-tannic acid-zinc acetate nanospheres (CA-TA-ZA NSs), realizing the fusion of hydrophilic and hydrophobic drug-food small molecules. Moreover, a novel "all-in-one" chitosan (CS)-based hydrogel functionalized by introducing drug-food small molecules self-assembled CA-TA-ZA NSs to the 3D network structures of CS is designed, integrating excellent antibacterial, antioxidant, anti-inflammatory and reducing oxidative stress damage abilities. Additionally, the multifunctional CS-based hydrogel can realize rapid in situ gelation at wound sites and completely cover the irregular wounds. All of these superiorities enable the CS-based hydrogel to clean the wound microenvironment, induce skin tissue remodeling, promote blood vessel repair and hair follicle regeneration, restore the immune system back to normal physiological activity, and accelerate wound healing. Therefore, this study offers a new perspective for the design of advanced functional materials with great application potential in the biomedical field.

show abstract

“…To promote wound healing, many dressings have been developed to control infection, promote hemostasis, and improve angiogenesis [ 132 , 133 , 134 ]. The development of hydrogel with excellent antibacterial properties, good compatibility, and degradable ability is a promising strategy for wound healing [ 135 , 136 ]. Hydrogels with a photothermal conversion ability can regulate the temperature by changing the NIR irradiation intensity/time, photothermal initiator concentration/ratio, and cycling time [ 137 , 138 ].…”

Section: Photothermal Hydrogels In Wound Healing and Bone Repairmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

View full text Add to dashboard Cite

Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

show abstract

Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Cited by 216 publications

References 56 publications

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Contact Info

Product

Resources

About