Multifunctional inulin tethered silver-graphene quantum dots nanotheranostic module for pancreatic cancer therapy

Joshi, Preeti Nigam; Agawane, Sachin B.; Athalye, Meghana C.; Jadhav, Vrushali H.; Sarkar, Dhiman; Prakash, Rajiv

doi:10.1016/j.msec.2017.03.176

Cited by 58 publications

(23 citation statements)

References 27 publications

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“…Zeta potential is an important criterion to determine the surface charge of nanocomposites that establishes the stability and absorption of nanocomposites at target site [57]. The conjugation of DOX with green synthesized NGO-AgNPs-PEG nanocomposites can further be interpreted by zeta potential measurement.…”

Section: Characterization Of Graphene Nanocomposites and Drugmentioning

confidence: 99%

“…Because of the deprotonation of the functional moieties present on the GO, negative surface charge of the DOX loaded nanocomposites was found. It has been reported that typically, nanoformulations with negative zeta potential exhibit high degree of stability in physiological condition and enhanced brain tumor targeting by traversing the blood brain barrier [57,58]. However, the positively charged nanocomposites favor protein adsorption to a larger extent, in case of free DOX, and it facilitates fast RES clearance [59].…”

Section: Characterization Of Graphene Nanocomposites and Drugmentioning

confidence: 99%

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Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Palai

Mondal

Chakraborti³

et al. 2019

SN Appl. Sci.

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In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were successfully prepared by eco-friendly non-toxic green synthesis following a novel syn-graphenization method using the aqueous leaf extract of Azadirachta indica (A. indica) (neem) as reducing agent. The prepared Smart pH stimuli responded nanoplatform was thoroughly characterized by various analytical techniques. Since a functional nanocarrier is very essential for cancer therapy, it could quickly guide the loaded anticancer drug to the tumor site to decrease the side effect. In order to overcome the side effects of doxorubicin (DOX), an anticancer drug, it was incorporated into amino PEGylated NGO-AgNPs nanocomposites. Considering drug loading and release studies, it may be concluded that improved drug loading efficiency (218%) and more pH-responsive controlled release (following Korsmeyer-Peppas model release kinetics) of DOX from NGO-AgNPs-PEG lead to a promising nanocarrier for the anticancer drug. The cytotoxicity study results, on HaCaT cell lines, indicated DOX-loaded PEGylated functionalized nanographene oxides, as compared to free DOX, had lesser harmful effect on normal cells than cancer cells. Increased cytotoxicity was exhibited in the cancerous cells (HeLa cell lines) treated with DOX loaded PEGylated silver functionalized nanographene oxide compared to covalently conjugated NGO-DOX. So, the effective delivery and release of the anticancer drug into acidic microenvironment of the targeted tumour cells would bring out higher therapeutic efficacy than pure NGO. Such a gold standard biocompatible PEGylated silver decorated NGO theranostic nanoplatform may be an excellent nano cargo for targeted and controlled drug delivery in cancer therapy.

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Section: Characterization Of Graphene Nanocomposites and Drugmentioning

confidence: 99%

Section: Characterization Of Graphene Nanocomposites and Drugmentioning

confidence: 99%

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Palai

Mondal

Chakraborti³

et al. 2019

SN Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…Test paper in (ii) was inserted into microplate of (iii). The liquid will go upwards along the strip due to capillary action ( 5 ). It was observed under UV after 6 min.…”

Section: Methodsmentioning

confidence: 99%

“…Compared to the traditional organic molecular fluorescent materials, QD has the following advantages: i) wide and continuous excitation spectrum, with large absorption coefficient and high quantum yield; ii) narrow and symmetric emission spectrum without trailing; iii) strong fluorescence intensity and high signal to noise ratio; iv) good light stability and strong ability to resist photobleaching; v) emission wavelength changes with particle size. Owing to its unique chemical and optical properties, QD has gradually been applied in tumor biological medicine, such as prostate cancer ( 4 ), pancreatic cancer ( 5 ), breast cancer ( 5 ), liver cancer ( 6 ), colorectal cancer ( 7 ) and nasopharyngeal carcinoma (NPC) ( 8 ). This study aimed to explore the 605 nm carboxyl of water-soluble quantum dots to assess the practicability of the NPC marker EBNA1 antibody.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of quantum dot immune chromatography nasopharyngeal carcinoma EBNA1 antibody

et al. 2018

Oncol Lett

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This study explored the 605 nm carboxyl of water-soluble quantum dots to assess the practicability of the nasopharyngeal carcinoma marker EBNA1 antibody. We used 605 nm carboxyl water-soluble quantum dots and nasopharyngeal carcinoma EBNA1 antigen in 1-(3-dimethylaminopropyl-3-2-ethylcarbonimine hydrochloride to generate quantum dot-labeled antigen. Gel imaging system showed that serum group and 60 patients with nasopharyngeal carcinoma had significant differences in 30 cases of normal adult serogroup brightness, Levene test in the two groups ELISA absorbance value was P<0.001, namely the nasopharyngeal carcinoma group and the normal adult serum group measured absorbance value difference was obvious. The statistical significance, and the detection technology were of high specificity and sensitivity. In conclusion, this study adopted double antigen clip combining immune chromatography test EBNA1 antibody in serum, compared with the traditional enzyme-linked immunoassays this method is more rapid, with simpler operation, rapid detection for developing quantum dot immune chromatography technology the EBNA1 antibody kit provides a theoretical basis.

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“…Optical-imaging agents as nanotheranostics already show promise with near-infrared (NIR) dyes such as the quantum dots being tested widely in preclinical models. 9,13,14 However, one of the challenges with NIR dyes as theranostics is the tissue interference and depth of penetration into tissues. 15–17 In the study we designed, our imaging probes were based on ceramic rare-earth (RE)-doped nanoparticles with tunable size and surface charge.…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Shortwave-Infrared-Emitting Nanophotonic Reporters for Gene-Therapy Applications

Zhao

Kantamneni

et al. 2018

ACS Biomater. Sci. Eng.

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Gene therapy is emerging as the next generation of therapeutic modality with United States Food and Drug Administration approved gene-engineered therapy for cancer and a rare eye-related disorder, but the challenge of real-time monitoring of on-target therapy response remains. In this study, we have designed a theranostic nanoparticle composed of shortwave-infrared-emitting rare-earth-doped nanoparticles (RENPs) capable of delivering genetic cargo and of real-time response monitoring. We showed that the cationic coating of RENPs with branched polyethylenimine (PEI) does not have a significant impact on cellular toxicity, which can be further reduced by selectively modifying the surface characteristics of the PEI coating using counter-ions and expanding their potential applications in photothermal therapy. We showed the tolerability and clearance of a bolus dose of RENPs@PEI in mice up to 7 days after particle injection in addition to the RENPs@PEI ability to distinctively discern lung tumor lesions in a breast cancer mouse model with an excellent signal-to-noise ratio. We also showed the availability of amine functional groups in the collapsed PEI chain conformation on RENPs, which facilitates the loading of genetic cargo that hybridizes with target gene in an in vitro cancer model. The real-time monitoring and delivery of gene therapy at on-target sites will enable the success of an increased number of gene- and cell-therapy products in clinical trials.

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Multifunctional inulin tethered silver-graphene quantum dots nanotheranostic module for pancreatic cancer therapy

Cited by 58 publications

References 27 publications

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Rapid detection of quantum dot immune chromatography nasopharyngeal carcinoma EBNA1 antibody

Surface-Modified Shortwave-Infrared-Emitting Nanophotonic Reporters for Gene-Therapy Applications

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