Multifunctional mesoporous silica-based nanocomposites: Synthesis and biomedical applications

Noreen, Sobia; Maqbool, Arslan; Maqbool, Irsah; Shafique, Afifa; Khan, Mudasser Muneer; Junejo, Yasmeen; Ahmed, Bilal; Anwar, M.; Majeed, Asma; Abbas, Muhammad; Naveed, Muhammad; Madni, Asadullah

doi:10.1016/j.matchemphys.2022.126132

Cited by 17 publications

(2 citation statements)

References 232 publications

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“…The peaks at 288.5 eV and 400.0 eV correspond to the C1s and N1s core levels of the ligands, respectively. The successful functionalization of the nanocomposites is crucial for their ability to selectively target cancer cells and pathogens [26].…”

Section: Characterization Of Nanocompositesmentioning

confidence: 99%

Development of Multifunctional Nanomaterials and Devices for Biomedical Applications

Srinath,

R.,

Dwivedi

et al. 2023

E3S Web Conf.

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The development of multifunctional nanomaterials and devices for biomedical applications has garnered significant attention in recent years due to their potential to revolutionize healthcare. In this study, we report the synthesis and characterization of novel nanomaterials with tailored properties for targeted drug delivery, imaging, and biosensing applications. We employed a bottom-up approach to design and fabricate nanocomposites comprising of biocompatible polymers, metallic nanoparticles, and quantum dots, which exhibit unique optical, magnetic, and electronic properties. The nanocomposites were functionalized with specific ligands to enable active targeting of cancer cells and pathogens. We also developed microfluidic devices for the efficient capture and analysis of circulating tumor cells (CTCs) using the synthesized nanomaterials. The performance of the nanomaterials and devices was evaluated in vitro and in vivo, demonstrating enhanced drug delivery efficiency, high-resolution imaging, and sensitive biosensing capabilities. Furthermore, we investigated the biocompatibility and long-term stability of the nanomaterials in physiological conditions. Our findings indicate that the developed multifunctional nanomaterials and devices hold great promise for advancing personalized medicine, early diagnosis, and targeted therapy. This study provides a comprehensive understanding of the design principles and potential applications of multifunctional nanomaterials in the biomedical field, paving the way for future research and clinical translation.

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Section: Characterization Of Nanocompositesmentioning

confidence: 99%

Development of Multifunctional Nanomaterials and Devices for Biomedical Applications

Srinath,

R.,

Dwivedi

et al. 2023

E3S Web Conf.

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show abstract

“…It ensures the structural orientation of the host molecules (metal ions) in the pores, which determines the increase in selectivity and adsorption capacity [27]. The synthesis of materials based on porous and mesoporous silica can be carried out by co-condensation, sol-gel methods, wet impregnation, direct incorporation, and alternative methods [28]. The template synthesis method is a relatively simple and easy method that controls the structure, morphology, and pore size through the template material [29].…”

Section: Introductionmentioning

confidence: 99%

Competitive Adsorption of Aqueous Cd(II) and Pb(II) Solutions onto Silicas Synthesized with Saponin as Template Agent

Simonescu,

Dumitru,

Zărnescu

et al. 2024

J. Compos. Sci.

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The aim of the research was to prepare silica adsorbents using an environmentally friendly pathway, a template synthesis with saponin biosurfactant as a structure-directing agent. The adsorbents prepared in this way exhibit improved adsorption properties while maintaining environmental innocuousness. For the preparation of porous silica, the biosurfactant template sol–gel method was used with tetraethoxysilane as a silica precursor. The silica adsorbents were analyzed by FTIR spectroscopy, nitrogen adsorption–desorption and SEM/EDX microscopy, TEM/HRTEM microscopy, and thermogravimetric analyses. Batch tests were carried out to remediate Pb(II)/Cd(II) ions in single/binary aqueous solutions, and the effect of the surfactant on the adsorption properties was assessed. The optimal adsorption parameters (pH, contact time, initial concentration of metal ions) have been determined. The adsorption was fitted using Langmuir and Freundlich adsorption isotherms and kinetic models. Mathematical modeling of the retention process of Pb(II) and Cd(II) ions from binary solutions indicated a competitive effect of each of the two adsorbed metal ions. The experimental results demonstrated that saponin has the effect of modifying the silica structure through the formation of pores, which are involved in the retention of metal ions from aqueous solutions and wastewater.

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Turning fluorescent silica nanoparticles for the removal and detection of 4-nitrophenol

Dat

et al. 2022

J Porous Mater

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Multifunctional mesoporous silica-based nanocomposites: Synthesis and biomedical applications

Cited by 17 publications

References 232 publications

Development of Multifunctional Nanomaterials and Devices for Biomedical Applications

Development of Multifunctional Nanomaterials and Devices for Biomedical Applications

Competitive Adsorption of Aqueous Cd(II) and Pb(II) Solutions onto Silicas Synthesized with Saponin as Template Agent

Turning fluorescent silica nanoparticles for the removal and detection of 4-nitrophenol

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