Multifunctional MIL-101 nanoparticles with Fenton-like reactions to Co-deliver LL-37 peptide and Vancomycin for targeted NIR imaging and Drug-resistant bacteria treatment

Lai, Luogen; Zou, Wanqing; Zhang, Yan; Tu, Yuanbiao; Li, Simeng; Xin, Tongxuan; Zhou, Tianyue; Xu, Shan; Zheng, Pengwu; Pan, Qingshan; Zhu, Wufu

doi:10.1016/j.cej.2022.135084

Cited by 40 publications

(18 citation statements)

References 66 publications

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“…aureus and E. coli with the hydrogels separately, Figure A,B shows that SF/Ag/C hydrogels had obvious antibacterial activity, and SF/Ag/C hydrogels could effectively inhibit the growth of Gram-positive and Gram-negative microorganisms within 12 h. The LIVE/DEAD staining assay showed similar results in Figure C,D. Both the untreated control and the SF hydrogel-treated group presented strong green fluorescence with almost no visible red fluorescence.…”

Section: Resultsmentioning

confidence: 62%

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Yan,

Li,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Excessive oxidative stress, bacterial infections, and inflammation are the primary factors impeding the healing of skin wounds. Bioactive hydrogels are commonly employed in the treatment of skin injuries. However, the limited solubility of many drugs and active agents in water significantly hampers their effectiveness in hydrogel dressings. In this research, prior to incorporation into the silk fibroin (SF) hydrogel matrix, two active agents curcumin and silver nanoparticles (Ag NPs) were decorated by silk sericin to improve their dispersibility and stability in water. The resultant SF/Ag/C hydrogels combined the biological safety and nontoxicity of SF, the antioxidant and anti-inflammatory efficacy of curcumin, and the antibacterial effect of Ag NPs. These properties effectively enhanced wound repair by reducing bacterial infections, mitigating oxidative stress, suppressing the expression of pro-inflammatory factors, and promoting angiogenesis. This study presented a straightforward approach for constructing bioactive hydrogels for the promotion of the wound healing process.

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Section: Resultsmentioning

confidence: 62%

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Yan,

Li,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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“…To further explore the effect of compound 2 on bacterial membranes, fluorescence microscopy was performed using NucGreen and EthD-III dyes to evaluate the integrity of the bacterial cell membrane (Figure 4). 31 NucGreen is a DNAspecific probe that permeates both intact and impaired bacterial cell membranes and binds to DNA to produce green fluorescence, while EthD-III only produces intense red fluorescence across damaged cell membranes. As shown in Figure 3, the negative control group only emitted green fluorescence, while both green and red fluorescence was observed in the group treated with 8 μg/mL compound 2.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism

Dong

Long

et al. 2023

J. Nat. Prod.

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Kuwanons A (1) and B (2) are two natural prenylated flavones isolated from the root bark of Morus alba L. In this study, the first total syntheses of kuwanons A (1) and B (2) were achieved from a common intermediate with overall yields of 6.6% and 11.6%, respectively. Kuwanon B (2) exhibited antibacterial activity against Gram-positive bacteria and concentration-dependent bactericidal activity against Staphylococcus aureus bacteria. Preliminary mechanism of action studies suggested that this compound killed bacteria rapidly by disrupting bacterial membrane integrity

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“…As with tumor treatment, H 2 O 2 -related antibacterial therapy mainly includes PDT, SDT, and CDT. 190–192 As described in Fig. 9a, Hu et al designed a phenylboronic acid-based nanozyme for antibacterial PDT.…”

Section: Biomedical Applications Of H2o2-responsive Nanomaterialsmentioning

confidence: 99%

Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

Huang,

Su,

Zhang

et al. 2023

RSC Adv.

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Multifunctional MIL-101 nanoparticles with Fenton-like reactions to Co-deliver LL-37 peptide and Vancomycin for targeted NIR imaging and Drug-resistant bacteria treatment

Cited by 40 publications

References 66 publications

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Total Synthesis of Kuwanons A and B and Discovery of Their Antibacterial Mechanism

Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

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