Multifunctional Modification of SIS Membrane with Chimeric Peptides to Promote Its Antibacterial, Osteogenic, and Healing‐Promoting Abilities for Applying to GBR

Mu, Yuzhu; Ma, Shiqing; Wei, Pengfei; Wang, Yonglan; Wei, Jing; Zhao, Yifan; Zhang, Lei; Wu, Jie; Zhao, Bo; Deng, Jiayin; Liu, Zihao

doi:10.1002/adfm.202101452

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…Bone defects caused by trauma, fracture, osteomyelitis, or bone tumor resection are often accompanied by infection, leading to poor clinical prognosis. [162][163][164][165] MPNs combine the specific functions of metal ions and polyphenol ligands, exhibiting unique advantages that are tailored to the desired properties of orthopedic biomaterials. Natural polyphenols contain plenty [159] Copyright 2021, Elsevier.…”

Section: Bone Regenerationmentioning

confidence: 99%

“…Bone defects caused by trauma, fracture, osteomyelitis, or bone tumor resection are often accompanied by infection, leading to poor clinical prognosis. [ 162–165 ] MPNs combine the specific functions of metal ions and polyphenol ligands, exhibiting unique advantages that are tailored to the desired properties of orthopedic biomaterials. Natural polyphenols contain plenty phenolic hydroxyl groups providing tissue adhesive, antioxidant, and anti‐inflammatory properties in addition to metal ions chelating ability, and some specific polyphenols have antimicrobial properties themselves.…”

Section: Antibacterial Application Of Mpns‐based Biomaterialsmentioning

confidence: 99%

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

et al. 2022

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Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.

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Section: Bone Regenerationmentioning

confidence: 99%

Section: Antibacterial Application Of Mpns‐based Biomaterialsmentioning

confidence: 99%

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

et al. 2022

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“…Masson's staining ( Fig. 8 b) was used to identity the collagen in bone matrix to observe the activity of osteogenesis [ 62 ]. The blue staining area (collagen) was larger in p 1&2 SIS-CA/Exs and p 3&4 SIS-CA/Exs groups than that in SIS-CA and SIS-CA/Exs groups, indicating that there is a lot of new bone.…”

Section: Resultsmentioning

confidence: 99%

Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration

et al. 2022

Materials Today Bio

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Injectable thermo-sensitive hydrogels composed of small intestinal submucosa (SIS) with exosomes derived from bone marrow mesenchymal stem cells (BMSCs) are desired for bone regeneration. However, poor mechanical properties limit the clinical application of SIS hydrogels. Herein, the mechanical properties of SIS hydrogels incorporated with 3-(3,4-dihydroxyphenyl) propionic acid (CA) are assessed. The results show that the mechanical properties of SIS hydrogels are improved. In addition, the retention and stability of exosomes over time at the defect site are also challenges. Fusion peptides are designed by connecting collagen-binding domines (CBDs) of collagen type I/III with exosomal capture peptides CP05 (CRHSQMTVTSRL) directly or via rigid linkers (EAAAK). In vitro experiments demonstrate that fusion peptides are contribute to promoting the positive effect of exosomes on osteogenic differentiation of BMSCs. Meanwhile, the results of hydrogels combining exosomes and fusion peptides in the treatment of rat skull defect models reveal that fusion peptides could enhance the retention and stability of exosomes, thereby strengthen the therapeutic effect for skull defects. Therefore, SIS hydrogels with CA modified by fusion peptides and exosomes appear to be a promising strategy in bone regenerative medicine.

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“…However, it has been reported that metallic implants have disadvantages, such as foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation [ 5 , 6 ]. In recent research on GBR membranes, prevention of bacterial infection, wound healing, and induction of bone regeneration after GBR surgery were found to be very important factors for the success of the surgery [ 7 ]. Therefore, it was assumed that developing a biocompatible implant with antimicrobial properties against representative micro-organisms and general pathogens present in the oral cavity can increase the success rate of implantation in the dental or orthopedic clinical field.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Biofunctionalization by Loading Manuka Oil on TiO2 Nanotubes

Kim

Jang

et al. 2022

Nanomaterials

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Metallic implants (mesh) for guided bone regeneration can result in foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation. This study aimed to reduce the possibility of surgical failure caused by microbial infection by loading antibacterial manuka oil in a biocompatible nanostructure surface on Ti and to induce stable bone regeneration in the bone defect. The manuka oil from New Zealand consisted of a rich β-triketone chemotype, leptospermone, which showed strong inhibitory effects against several bacteria, even at very low oil concentrations. The TiO2 nanotubular layer formed by anodization effectively enhanced the surface hydrophilicity, bioactivity, and fast initial bone regeneration. A concentration of manuka oil in the range of 0.02% to less than 1% can have a synergistic effect on antibacterial activity and excellent biocompatibility. A manuka oil coating (especially with a concentration of 0.5%) on the TiO2 nanotube layer can be expected not only to prevent stenosis of the connective tissue around the mesh and inflammation by microbial infection but also to be effective in stable and rapid bone regeneration.

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Multifunctional Modification of SIS Membrane with Chimeric Peptides to Promote Its Antibacterial, Osteogenic, and Healing‐Promoting Abilities for Applying to GBR

Cited by 23 publications

References 51 publications

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration

Enhancement of Biofunctionalization by Loading Manuka Oil on TiO2 Nanotubes

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