“…The SEM images show the effectiveness of LCH crystals on the wounded sites. After the release of LCH, the bandage surface became rigid, rough, and flexible (Jahan et al, 2019;Silva et al, 2020;Synytsya et al, 2020).…”
In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.
“…The SEM images show the effectiveness of LCH crystals on the wounded sites. After the release of LCH, the bandage surface became rigid, rough, and flexible (Jahan et al, 2019;Silva et al, 2020;Synytsya et al, 2020).…”
In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.
“…The L929 fibroblast cells were properly adhered to LNF/NFC patch, whereas poor adhesion of L929 fibroblasts was detected with a pristine NFC patch. The patch has no adverse effects on L929 fibroblast cell lines [ 211 ]. Erdagi et al.…”
Section: Applications In Tissue Engineering and Regenerative Medicinementioning
confidence: 99%
“… Fig. 8 (a) Schematic representation of the preparation of NFC-LNFs mixture and digital photographs of their patches [ 211 ]; (b) Picture of inhibition zones of neomycin and mechanism of neomycin loaded hydrogels [ 178 ]; (c) Wound healing of different groups of treatment (left), picture of the gross appearance of a wound treated with PDA/TOCNFs hydrogel and PDATH/TOCNFs hydrogel (14.4 wt% drug loading) at days of 0, 5, 10 and 15 [ 213 ]. (d) Changes in body weight of experimental mice within 7 days (left), changes in wound area of mice within 7 days (middle), Healing images of a wound of mice in a week (right) [a – control group, b – treatment with BN/EPTAC- β-CD hydrogel, c – treatment with TB-DCMC hydrogel, and d – treatment with BN/EPTAC- β-CD -TB-DCMC hydrogel] [ 214 ].…”
Section: Applications In Tissue Engineering and Regenerative Medicinementioning
Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.
“…Lysozyme has antibacterial properties against gram-positive bacteria. It can be used to prevent bacterial infection and promote the wound healing [31,32]. Lysozyme has also been a promising candidate in the application of pharmacological functions.…”
This paper presents a facile and low-cost strategy for fabrication lysozyme-loaded mesoporous silica nanotubes (MSNTs) by using silk fibroin (SF) nanofiber templates. The “top-down method” was adopted to dissolve degummed silk in CaCl2/ formic acid (FA) solvent, and the solution containing SF nanofibrils was used for electrospinning to prepare SF nanofiber templates. As SF contains a large number of -OH, -NH2 and -COOH groups, the silica layer could be easily formed on its surface by the Söber sol-gel method without adding any surfactant or coupling agent. After calcination, the MSNTs were obtained with inner diameters about 200 nm, the wall thickness ranges from 37 ± 2 nm to 66 ± 3 nm and the Brunauer–Emmett–Teller (BET) specific surface area was up to 200.48 m2/g, the pore volume was 1.109 cm3/g. By loading lysozyme, the MSNTs exhibited relatively high drug encapsulation efficiency up to 31.82% and an excellent long-term sustained release in 360 h (15 days). These results suggest that the MSNTs with the hierarchical structure of mesoporous and macroporous will be a promising carrier for applications in biomacromolecular drug delivery systems.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
