Multifunctional nanoparticles as optical biosensing probe for breast cancer detection: A review

Shahbazi, Neda; Zare‐Dorabei, Rouholah; Naghib, Seyed Morteza

doi:10.1016/j.msec.2021.112249

Cited by 42 publications

(17 citation statements)

References 185 publications

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“…Different shapes of plasmonic nanostructures (e.g., AuNPs and AgNPs) have been widely used to identify different biomolecules, especially for BC biomarker detection. − The synthesized spherical AuNPs have been decorated with the negative citrate groups, making them available to interact with positively charged components. We have added citrate-capped AgNPs to our sensing probe to increase the selectivity.…”

Section: Resultsmentioning

confidence: 99%

Design of a Ratiometric Plasmonic Biosensor for Herceptin Detection in HER2-Positive Breast Cancer

Shahbazi

Zare‐Dorabei

Naghib

2022

ACS Biomater. Sci. Eng.

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Breast cancer is the most common cause of cancer death in women; therefore, its early detection and treatment are crucial. To achieve this goal, we designed an optical sensor based on direct interaction of trastuzumab [Herceptin (HER)], a monoclonal antibody used to treat HER2-positive breast cancer, with plasmonic nanoparticles. Surface-modified gold nanoparticles (AuNPs) have gained considerable attention in biosensing techniques over the last years, which actuated these nanoparticles to the heart of various biosensing notions. We have exploited the localized surface plasmon resonance (LSPR) of gold nanoparticles to determine HER in human serum. AuNPs were decorated with negatively charged citrate ions, yielding enhanced direct-surface interaction with HER antibodies. The AuNPs are mixed with silver nanoparticles (AgNPs) in an optimized ratio to increase selectivity and sensitivity further. AuNPs detect the HER antibodies using LSPR, whereas AgNPs help monitor interferences’ effect on the sensing media. The three effective factors in HER sensing, including the nanoparticle ratio, temperature, and pH were optimized via response surface methodology (RSM) based on the central composite design (CCD). The sensor’s response toward HER was achieved in the linear range of 0.5 × 10–7 to 40 × 10–7 M with the detection limit of 3.7 × 10–9 M and relative standard deviation (RSD) less than 5%. The selectivity of the LSPR sensor was assessed by monitoring its response toward HER in the presence of other biological molecules with similar physicochemical properties. Rapid response time (less than 1 min), selectivity, and the simplicity of the developed LSPR-based sensor are the key advantages of the developed sensor.

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Section: Resultsmentioning

confidence: 99%

Design of a Ratiometric Plasmonic Biosensor for Herceptin Detection in HER2-Positive Breast Cancer

Shahbazi

Zare‐Dorabei

Naghib

2022

ACS Biomater. Sci. Eng.

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“…The integration of imaging and nanoprobes for cancer diagnosis and treatment may facilitate better responses and reduced side effects in normal tissues ( 14 , 16 , 17 ). This means that nano-biosensors are likely to be critical to the development of novel cancer therapies and diagnostics, as they can be used to detect cancer biomarkers, map cancer cells, and monitor metastasis in response to different substrates and conditions ( 18 , 19 ). Thus, the cancer diagnosis and treatment landscape has expanded considerably over the last decade, propelled by advances in novel therapies and improved diagnostics ( 14 , 16 , 17 , 20 ).…”

Section: Nanomaterials and Cancer Diagnosismentioning

confidence: 99%

Nanotech Probes: A Revolution in Cancer Diagnosis

et al. 2022

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Recent advances in nanotechnologies for cancer diagnosis and treatment have received considerable attention worldwide. Nanoparticles are being used to create nanodrugs and probes to diagnose and treat a variety of diseases, including cancer. Nanomedicines have unique advantages, such as increased surface-to-volume ratios, which enable them to interact with, absorb, and deliver small biomolecules to a very specific target, thereby improving the effectiveness of both probes and drugs. Nanoprobe biotechnology also plays an important role in the discovery of novel cancer biomarkers, and nanoprobes have become an important part of early clinical diagnosis of cancer. Various organic and inorganic nanomaterials have been developed as biomolecular carriers for the detection of disease biomarkers. Thus, we designed this review to evaluate the advances in nanoprobe technology in tumor diagnosis.

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“…Carbon quantum dots (CQDs) have received considerable attention due to their simple production and versatile functions in biomedical and optical applications. − These zero-dimensional (0D) carbon nanostructures with a size of typically below 10 nm are biocompatible, photostable, and have tunable photoluminescence (PL) properties. − The tunable PL emission of CQDs and the available facile functionalization strategies make them an ideal candidate for fluorometric optical sensors. − The CQDs with carboxyl, hydroxyl, or carbonyl functional groups can be easily dispersed in aqueous solutions, while other functional moieties can also be used to provide selectivity for the desired analyte. , …”

Section: Introductionmentioning

confidence: 99%

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

Saboorizadeh

Zare‐Dorabei

2022

ACS Biomater. Sci. Eng.

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, an immunosuppressive drug, has been widely prescribed for treating leukemia and autoimmune diseases. The level of the 6-MP drug in body fluids is of great interest due to the severe health problems related to its overdose. This study used a facile microwave preparation route to synthesize carbon quantum dots (CQDs) using glutathione and formamide as carbon sources. The obtained monodispersed quantum dots showed dual fluorescence emission with a sensitive affinity toward the 6-MP drug. The sensor's response was optimized by tuning the temperature, pH, and volume ratio of the probe. The prepared ratiometric fluorescence method showed accurate measurements for determining mercaptopurine in aqueous solutions in the concentration range of 1.4−7.6 mg L −1 with the limit of detection of 1.3 mg L −1 . The sensor's performance was assessed in complex solutions, human urine, and human plasma sample and recovery values in the range of 88− 127% were obtained. The reliable dual fluorometric sensor showed promising results for 6-MP determination and potential application for the determination of other chemical and biochemical species.

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Multifunctional nanoparticles as optical biosensing probe for breast cancer detection: A review

Cited by 42 publications

References 185 publications

Design of a Ratiometric Plasmonic Biosensor for Herceptin Detection in HER2-Positive Breast Cancer

Design of a Ratiometric Plasmonic Biosensor for Herceptin Detection in HER2-Positive Breast Cancer

Nanotech Probes: A Revolution in Cancer Diagnosis

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

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