Multifunctional Nanoparticles for Dual Imaging

Ali, Zulqurnain; Abbasi, Azhar Z.; Zhang, Feng; Arosio, Paolo; Lascialfari, A.; Casula, Maria Francesca; Wenk, Alexander; Kreyling, Wolfgang G.; Plapper, R.; Seidel, Michael; Nießner, Reinhard; Knoll, Johann; Seubert, A.; Parak, Wolfgang J.

doi:10.1021/ac103261y

Cited by 113 publications

(109 citation statements)

References 83 publications

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“…25,26 The capability to perform more than one simple task is one of the most promising aspects of bionanotechnology, i.e., the so-called multifunctional NPs. The examples in the literature about multifunctional NPs are manifold, 15,[27][28][29][30][31] and the combinations of molecules and NPs are very diverse. Figure 1 schematically depicts several possible functionalities, which are categorized depending on the NPs' design.…”

Section: Biochemistry and Biomolecular Processesmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Biochemistry and Biomolecular Processesmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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“…Due to the drawbacks of gadolinium, several trials using SPIOs and fluorophores had been done by different groups [12]. SPIOs have relatively low toxicity and they were also characterized to have excellent negative MR contrast effects and hyperthermia effects by converting the energy absorbed from an AC magnetic field to the thermal energy [13].…”

Section: Introductionmentioning

confidence: 99%

In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles

Key

Cooper

Kim

et al. 2012

Journal of Controlled Release

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“…[810] Simultaneous combination of the anatomic information provided by both techniques certainly comes in handy for better diagnosis and further decisions to overcome the limitations of each single procedure as a result of higher payload of contrast producing material with longer blood circulation times. [811] These hybrid dual imaging agents composed of gold and iron oxide nanoparticles (GION) can be used to provide better CT contrast and relatively higher T 2 relaxivity in MRI even in the form of core shell nanoparticles or SPION-gold dumbbell nanocomposites. [812] Hu et al [810b] prepared Fe 3 O 4 /Au composite nanoparticles for targeted dual mode MR/CT imaging of tumor.…”

Section: Computer Tomographymentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Multifunctional Nanoparticles for Dual Imaging

Cited by 113 publications

References 83 publications

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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